Phage selection of cyclic peptide antagonists with increased stability toward intestinal proteases

Protein Engineering, Design and Selection

Volumn 26, Issue 1, 2013, Pages 81-89

  Baeriswyl, Vanessa ^a   Heinis, Christian ^a  

^a EPFL   (Switzerland)

Author keywords

bicyclic peptide; phage display; plasma kallikrein; proteolytic phage display; proteolytic stability

Indexed keywords

AFFINITY SELECTION; CYCLIC PEPTIDES; INHIBITORY ACTIVITY; ORAL DELIVERY; PEPTIDE DRUGS; PHAGE DISPLAY; PHAGE LIBRARIES; PHAGE SELECTION; PLASMA KALLIKREIN; POTENT INHIBITOR; PROLINE RESIDUES; PROTEOLYTIC DEGRADATION; PROTEOLYTIC STABILITY; THERAPEUTIC TARGETS;

AMINO ACIDS; PLASMA STABILITY;

PEPTIDES;

INTESTINE ENZYME; KALLIKREIN; PANCREAS EXTRACT; PANCREATIN; PROLINE;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; BIOPANNING; IC 50; INTESTINE FLUID; MOUSE; NONHUMAN; PHAGE DISPLAY TECHNOLOGY; PRESSURE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN ISOLATION; PROTEIN STABILITY;

AMINO ACID SEQUENCE; ANIMALS; INTESTINES; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES, CYCLIC; PLASMA KALLIKREIN; PROLINE; PROTEIN STABILITY; PROTEOLYSIS; SERINE PROTEINASE INHIBITORS; SWINE;

EID: 84871205538     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs085     Document Type: Article

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