Adult-onset opsoclonus-myoclonus syndrome

Archives of Neurology

Volumn 69, Issue 12, 2012, Pages 1598-1607

  Klaas, James P ^a   Ahlskog, J Eric ^a   Pittock, Sean J ^a   Matsumoto, Joseph Y ^a   Aksamit, Allen J ^a   Bartleson, J D ^a   Kumar, Rajeev ^b   McEvoy, Kathleen F ^a   McKeon, Andrew ^a  

^a Mayo Clinic College of Medicine   (United States)

^b Colorado Neurological Institute Movement Disorders Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; BACLOFEN; CLONAZEPAM; CORTICOSTEROID; ETIRACETAM; GABAPENTIN; IMMUNOGLOBULIN; METHYLPREDNISOLONE ACETATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEURONAL NUCLEAR ANTIBODY TYPE 2; PREDNISONE; UNCLASSIFIED DRUG; VALPROATE SEMISODIUM; VALPROIC ACID;

ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; BALANCE IMPAIRMENT; BRAIN DISEASE; BREAST ADENOCARCINOMA; CAUSE OF DEATH; CLINICAL ARTICLE; COMORBIDITY; DISEASE COURSE; DISEASE SURVEILLANCE; DIZZINESS; FEMALE; FOLLOW UP; HEART INFARCTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IDIOPATHIC DISEASE; IMMUNOTHERAPY; LUNG SMALL CELL CANCER; MALE; MEDICAL RECORD REVIEW; METABOLIC DISORDER; NAUSEA; NEUROLOGIC DISEASE; NEUROLOGY; ONSET AGE; OPSOCLONUS MYOCLONUS SYNDROME; OUTCOME ASSESSMENT; PARANEOPLASTIC NEUROPATHY; PLASMAPHERESIS; PRIORITY JOURNAL; REMISSION; SPEECH DISORDER; SYMPTOMATOLOGY; TELECONSULTATION; TREATMENT DURATION; TREATMENT RESPONSE; TREMOR; VISUAL DISORDER; VOMITING;

EID: 84871205440     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneurol.2012.1173     Document Type: Article

References (85)

1. Kinsbourne M. Myoclonic encephalopathy of infants. J Neurol Neurosurg Psychiatry. 1962;25(3):271-276.
2. Rudnick E, Khakoo Y, Antunes NL, et al. Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: clinical outcome and antineuronal antibodies - a report from the Children's Cancer Group Study. Med Pediatr Oncol . 2001;36(6):612-622. (Pubitemid 32402157)
3. Hayward K, Jeremy RJ, Jenkins S, et al. Long-term neurobehavioral outcomes in children with neuroblastoma and opsoclonus-myoclonus-ataxia syndrome: relationship to MRI findings and anti-neuronal antibodies. J Pediatr. 2001;139(4):552-559. (Pubitemid 32977271)
4. Mitchell WG, Davalos-Gonzalez Y, Brumm VL, et al. Opsoclonus-ataxia caused by childhood neuroblastoma: developmental and neurologic sequelae. Pediatrics. 2002;109(1):86-98. (Pubitemid 34049431)
5. Dropcho EJ, Kline LB, Riser J. Antineuronal (anti-Ri) antibodies in a patient with steroid-responsive opsoclonus-myoclonus. Neurology. 1993;43(1):207-211. (Pubitemid 23035383)
6. Pittock SJ, Lucchinetti CF, Lennon VA. Anti-neuronal nuclear autoantibody type 2: paraneoplastic accompaniments. Ann Neurol. 2003;53(5):580-587. (Pubitemid 36529431)
7. Bataller L, Graus F, Saiz A, Vilchez JJ; Spanish Opsoclonus-Myoclonus Study Group. Clinical outcome in adult onset idiopathic or paraneoplastic opsoclonus-myoclonus. Brain. 2001;124(pt 2):437-443. (Pubitemid 32142415)
8. Smith JH, Dhamija R, Moseley BD, et al. N-methyl-D-aspartate receptor autoimmune encephalitis presenting with opsoclonus-myoclonus: treatment response to plasmapheresis. Arch Neurol. 2011;68(8):1069-1072.
9. McKeon A, Tracy JA, Pittock SJ, Parisi JE, Klein CJ, Lennon VA. Purkinje cell cytoplasmic autoantibody type 1 accompaniments: the cerebellum and beyond. Arch Neurol. 2011;68(10):1282-1289.
10. McKeon A, Lennon VA, Lachance DH, Fealey RD, Pittock SJ. Ganglionic acetyl- choline receptor autoantibody: oncological, neurological, and serological accompaniments. Arch Neurol. 2009;66(6):735-741.
11. Lennon VA, Kryzer TJ, Griesmann GE, et al. Calcium-channel antibodies in the Lambert-Eaton syndrome and other paraneoplastic syndromes. N Engl J Med. 1995;332(22):1467-1474.
12. Tan KM, Lennon VA, Klein CJ, Boeve BF, Pittock SJ. Clinical spectrum of voltagegated potassium channel autoimmunity. Neurology. 2008;70(20):1883-1890. (Pubitemid 351684641)
13. Yu Z, Kryzer TJ, Griesmann GE, Kim K, Benarroch EE, Lennon VA. CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann Neurol. 2001;49(2):146-154. (Pubitemid 32157990)
14. Graus F, Vincent A, Pozo-Rosich P, et al. Anti-glial nuclear antibody: marker of lung cancer-related paraneoplastic neurological syndromes. J Neuroimmunol. 2005;165(1-2):166-171. (Pubitemid 40984634)
15. Quek A, Britton JW, McKeon A, et al. Autoimmune epilepsy: clinical characteristics and response to immunotherapy. Arch Neurol. 2012;69(5):582-593. doi: 10.1001/archneurol.2011.2985.
16. Pittock SJ, Yoshikawa H, Ahlskog JE, et al. Glutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunction. Mayo Clin Proc. 2006;81(9):1207-1214. (Pubitemid 44316286)
17. Ross AT, Zeman W. Opsoclonus, occult carcinoma, and chemical pathology in dentate nuclei. Arch Neurol. 1967;17(5):546-551.
18. Cogan DG. Opsoclonus, body tremulousness, and benign encephalitis. Arch Ophthalmol. 1968;79(5):545-551.
19. Baringer JR, Sweeney VP, Winkler GF. An acute syndrome of ocular oscillations and truncal myoclonus. Brain. 1968;91(3):473-480.
20. McLean DR. Polymyoclonia with opsoclonus. Neurology. 1970;20(5):508-512.
21. Brichet B, André JM, Reny A, Weber M. EMG study of opsoclonus occurring in vertebro-basilar insufficiency. Electroencephalogr Clin Neurophysiol. 1970; 29(5):534.
22. Boddie HG. Ocular bobbing and opsoclonus: two abnormal spontaneous eye movements occurring in the same patient: case report. J Neurol Neurosurg Psychiatry. 1972;35(5):739-742.
23. Vignaendra V, Lim CL. Electro-oculographic analysis of opsoclonus: its relationship to saccadic and nonsaccadic eye movements. Neurology. 1977;27(12):1129-1133. (Pubitemid 8260726)
24. Jabbari B, Urban E. Abnormal visual-evoked responses and opsoclonus. J Clin Neuroophthalmol. 1981;1(4):269-271. (Pubitemid 13046442)
25. Sheinman BD, Gawler J. Opsoclonus and polymyoclonia complicating oat-cell carcinoma of the bronchus. Postgrad Med J. 1982;58(685):704-705. (Pubitemid 13244069)
26. Graus F, Cordon-Cardo C, Cho ES, Posner JB. Opsoclonus and oat cell carcinoma of lung: lack of evidence for anti-CNS antibodies. Lancet. 1984;1(8392):1479. (Pubitemid 14080787)
27. Sachdeva JR Jr, Singh N, Mann GS. Acute cerebellar ataxia with opsoclonus. J Assoc Physicians India. 1984;32(5):460.
28. Rosenberg NL. Hearing loss as an initial symptom of the opsoclonus-myoclonus syndrome. Arch Neurol. 1984;41(9):998-999. (Pubitemid 14073338)
29. Matsumura K, Sonoh M, Tamaoka A, Sakuta M. Syndrome of opsoclonus-myoclonus in hyperosmolar nonketotic coma. Ann Neurol. 1985;18(5):623-624.
30. Digre KB. Opsoclonus in adults: report of three cases and review of the literature. Arch Neurol. 1986;43(11):1165-1175. (Pubitemid 17174446)
31. Dropcho E, Payne R. Paraneoplastic opsoclonus-myoclonus: association with medullary thyroid carcinoma and review of the literature. Arch Neurol. 1986;43(4):410-415. (Pubitemid 16106966)
32. Anderson NE, Budde-Steffen C, Rosenblum MK, et al. Opsoclonus, myoclonus, ataxia, and encephalopathy in adults with cancer: a distinct paraneoplastic syndrome. Medicine (Baltimore). 1988;67(2):100-109.
33. Scharf D. Opsoclonus-myoclonus following the intranasal usage of cocaine. J Neurol Neurosurg Psychiatry. 1989;52(12):1447-1448. (Pubitemid 20049134)
34. Scholz J, Vieregge P, Ruff C. Paraneoplastic opsoclonus-myoclonus syndrome in metastatic ovarian carcinoma. J Neurol Neurosurg Psychiatry. 1994;57(6):763-764. (Pubitemid 24182973)
35. Hersh B, Dalmau J, Dangond F, Gultekin S, Geller E, Wen PY. Paraneoplastic opsoclonus- myoclonus associated with anti-Hu antibody. Neurology. 1994;44(9):1754-1755. (Pubitemid 24286661)
36. Casado JL, Gil-Peralta A, Graus F, Arenas C, Lopez JM, Alberca R. Anti-Ri antibodies associated with opsoclonus and progressive encephalomyelitis with rigidity. Neurology. 1994;44(8):1521-1522. (Pubitemid 24247452)
37. Caviness JN, Forsyth PA, Layton DD, McPhee TJ. The movement disorder of adult opsoclonus. Mov Disord. 1995;10(1):22-27.
38. Pless M, Ronthal M. Treatment of opsoclonus-myoclonus with high-dose intravenous immunoglobulin. Neurology. 1996;46(2):583-584. (Pubitemid 26081361)
39. Gwinn KA, Caviness JN. Electrophysiological observations in idiopathic opsoclonus-myoclonus syndrome. Mov Disord. 1997;12(3):438-442. (Pubitemid 27216148)
40. Jongen JL, Moll WJ, Sillevis Smitt PA, Vecht CJ, Tijssen CC. Anti-Ri positive op-soclonus- myoclonus-ataxia in ovarian duct cancer. J Neurol. 1998;245(10):691-692. (Pubitemid 28439038)
41. Berger JR, Mehari E. Paraneoplastic opsoclonus-myoclonus secondary to malignant melanoma. J Neurooncol. 1999;41(1):43-45. (Pubitemid 29161020)
42. Moretti R, Torre P, Antonello RM, Nasuelli D, Cazzato G. Opsoclonus-myoclonus syndrome: gabapentin as a new therapeutic proposal. Eur J Neurol. 2000;7(4):455-456. (Pubitemid 32280910)
43. De Luca S, Terrone C, Crivellaro S, et al. Opsoclonus-myoclonus syndrome as a paraneoplastic manifestation of renal cell carcinoma: a case report and review of the literature. Urol Int. 2002;68(3):206-208. (Pubitemid 34264250)
44. Verma A, Brozman B. Opsoclonus-myoclonus syndrome following Epstein-Barr virus infection. Neurology. 2002;58(7):1131-1132. (Pubitemid 34298565)
45. Wirtz PW, Sillevis Smitt PA, Hoff JI, et al. Anti-Ri antibody positive opsoclonus-myoclonus in a male patient with breast carcinoma. J Neurol. 2002;249(12):1710-1712. (Pubitemid 36269264)
46. Glatz K, Meinck HM, Wildemann B. Parainfectious opsoclonus-myoclonus syndrome: high dose intravenous immunoglobulins are effective. J Neurol Neurosurg Psychiatry. 2003;74(2):279-280. (Pubitemid 36160702)
47. Blaes F, Jauss M, Kraus J, et al. Adult paraneoplastic opsoclonus-myoclonus syndrome associated with antimitochondrial autoantibodies. J Neurol Neurosurg Psychiatry. 2003;74(11):1595-1596. (Pubitemid 37392892)
48. Erlich R, Morrison C, Kim B, Gilbert MR, Alrajab S. ANNA-2: an antibody associated with paraneoplastic opsoclonus in a patient with large-cell carcinoma of the lung with neuroendocrine features-correlation of clinical improvement with tumor response. Cancer Invest. 2004;22(2):257-261. (Pubitemid 38725180)
49. Koide R, Sakamoto M, Tanaka K, Hayashi H. Opsoclonus-myoclonus syndrome during pregnancy. J Neuroophthalmol. 2004;24(3):273.
50. Weizman DA, Leong WL. Anti-Ri antibody opsoclonus-myoclonus syndrome and breast cancer: a case report and a review of the literature. J Surg Oncol. 2004; 87(3):143-145. (Pubitemid 39167395)
51. Kumar A, Lajara-Nanson WA, Neilson RW Jr. Paraneoplastic opsoclonus-myoclonus syndrome: initial presentation of non-Hodgkin's lymphoma. J Neurooncol. 2005;73(1):43-45. (Pubitemid 40823265)
52. Khosla JS, Edelman MJ, Kennedy N, Reich SG. West Nile virus presenting as opsoclonus-myoclonus cerebellar ataxia. Neurology. 2005;64(6):1095. (Pubitemid 40388478)
53. Jung KY, Youn J, Chung CS. Opsoclonus-myoclonus syndrome in an adult with malignant melanoma. J Neurol. 2006;253(7):942-943. (Pubitemid 44100450)
54. Bartos A. Effective high-dose clonazepam treatment in two patients with opsoclonus and myoclonus: GABAergic hypothesis. Eur Neurol . 2006;56(4):240-242. (Pubitemid 44940014)
55. Hauspy J, Nevin A, Harley I, et al. Paraneoplastic syndrome in vaginal melanoma: a case report and review of the literature. Int J Gynecol Cancer. 2007;17(5):1159-1163. (Pubitemid 47414809)
56. Zaganas I, Prinianakis G, Xirouchaki N, Mavridis M. Opsoclonus-myoclonus syndrome associated with cytomegalovirus encephalitis. Neurology. 2007;68(19):1636. (Pubitemid 46717996)
57. Ohara S, Iijima N, Hayashida K, Oide T, Katai S. Autopsy case of opsoclonus-myoclonus- ataxia and cerebellar cognitive affective syndrome associated with small cell carcinoma of the lung. Mov Disord. 2007;22(9):1320-1324. (Pubitemid 47325042)
58. Skeie GO, Eldøen G, Skeie BS, Midgard R, Kristoffersen EK, Bindoff LA. Opsoclonus myoclonus syndrome in two cases with neuroborreliosis. Eur J Neurol. 2007;14(12):e1-e2. doi:10.1111/j.1468-1331.2007.01959.x. (Pubitemid 350135290)
59. Markakis I, Alexiou E, Xifaras M, Gekas G, Rombos A. Opsoclonus- myoclonusataxia syndrome with autoantibodies to glutamic acid decarboxylase. Clin Neurol Neurosurg. 2008;110(6):619-621.
60. Van Diest D, De Raeve H, Claes J, Parizel PM, De Ridder D, Cras P. Paraneoplastic opsoclonus-myoclonus-ataxia (OMA) syndrome in an adult patient with esthesioneuroblastoma. J Neurol. 2008;255(4):594-596.
61. Brieva-Ruíz L, Diaz-Hurtado M, Matias-Guiu X, Márquez- Medina D, Tarragona J, Graus F. Anti-Ri-associated paraneoplastic cerebellar degeneration and breast cancer: an autopsy case study. Clin Neurol Neurosurg. 2008;110(10):1044-1046.
62. Musunuru K, Kesari S. Paraneoplastic opsoclonus-myoclonus ataxia associated with non-small-cell lung carcinoma. J Neurooncol. 2008;90(2):213-216.
63. Hassan KA, Kalemkerian GP, Trobe JD. Long-term survival in paraneoplastic opsoclonus- myoclonus syndrome associated with small cell lung cancer. J Neuroophthalmol. 2008;28(1):27-30. (Pubitemid 351416888)
64. de Beer F, Schreurs MW, Foncke EM. False positive autoantibodies to glutamic acid decarboxylase in opsoclonus-myoclonus-ataxia syndrome after intravenous treatment with immunoglobulin. Clin Neurol Neurosurg. 2009;111(7):643-644.
65. Scott KM, Parker F, Heckmann JM. Opsoclonus-myoclonus syndrome and HIV-infection. J Neurol Sci. 2009;284(1-2):192-195.
66. Ayarza A, Parisi V, Altclas J, et al. Opsoclonus-myoclonus-ataxia syndrome and HIV seroconversion. J Neurol. 2009;256(6):1024-1025.
67. Vandervest KM, Schwarz MI. A 76-year-old woman with acute CNS symptoms and pulmonary nodules. Chest. 2009;136(6):1686-1689.
68. Flabeau O, Meissner W, Foubert-Samier A, Guehl D, Desbordes P, Tison F. Opsoclonus myoclonus syndrome in the context of salmonellosis. Mov Disord. 2009;24(15):2306-2308.
69. Josephson CB, Grant I, Benstead T. Opsoclonus-myoclonus with multiple paraneoplastic syndromes and VGCC antibodies. Can J Neurol Sci. 2009;36(4):512-514.
70. Lou E, Hensley ML, Lassman AB, Aghajanian C. Paraneoplastic opsoclonus-myoclonus syndrome secondary to immature ovarian teratoma. Gynecol Oncol. 2010;117(2):382-384.
71. Kurian M, Lalive PH, Dalmau JO, Horvath J. Opsoclonus-myoclonus syndrome in anti-N-methyl-D-aspartate receptor encephalitis. Arch Neurol. 2010;67(1):118-121.
72. Bier SA, Hile DC. Emergency department presentation of a rare neurological disorder. J Emerg Med. 2010;38(4):452-455.
73. Korn-Lubetzki I, Steiner-Birmanns B, Jaworowski S. Anxiety as initial diagnosis in opsoclonus myoclonus syndrome. Arch Neurol. 2010;67(9):1154-1155.
74. Kanjanasut N, Phanthumchinda K, Bhidayasiri R. HIV-related opsoclonus-myoclonus- ataxia syndrome: report on two cases. Clin Neurol Neurosurg. 2010;112(7):572-574.
75. Sotirchos ES, Dorsey ER, Tan IL, Zee DS. Opsoclonus-myoclonus syndrome and exaggerated startle response associated with small-cell lung cancer. Mov Disord. 2011;26(9):1769-1770.
76. Nadal E, Bruna J, Ochoa de Olza M, Antonio M, Cardenal F. Paraneoplastic opsoclonus- myoclonus syndrome as a new and single manifestation of relapsing disease in a patient with small cell lung cancer. J Thorac Oncol. 2011;6(5):968-969.
77. Simister RJ, Ng K, Lang B, Beckles M, Chao D, McCabe DJ. Sequential fluctuating paraneoplastic ocular flutter-opsoclonus-myoclonus syndrome and Lambert-Eaton myasthenic syndrome in small-cell lung cancer. J Neurol Neurosurg Psychiatry. 2011;82(3):344-346.
78. Dassan P, Clarke C, Sharp DJ. A case of poststreptococcal opsoclonus-myoclonus syndrome. Mov Disord. 2007;22(10):1490-1491. (Pubitemid 47280639)
79. Whiteley AM, Swash M, Urich H. Progressive encephalomyelitis with rigidity. Brain. 1976;99(1):27-42.
80. McKeon A, Pittock SJ, Glass GA, et al. Whole-body tremulousness: isolated generalized polymyoclonus. Arch Neurol. 2007;64(9):1318-1322. (Pubitemid 47403088)
81. Cardoso F. Chorea gravidarum. Arch Neurol. 2002;59(5):868-870. (Pubitemid 34517775)
82. Kranick SM, Mowry EM, Colcher A, Horn S, Golbe LI. Movement disorders and pregnancy: a review of the literature. Mov Disord. 2010;25(6):665-671.
83. Pranzatelli MR, Tate ED, Travelstead AL, et al. Insights on chronic-relapsing opsoclonus- myoclonus from a pilot study of mycophenolate mofetil. J Child Neurol. 2009;24(3):316-322.
84. Pranzatelli MR. The immunopharmacology of the opsoclonus-myoclonus syndrome. Clin Neuropharmacol. 1996;19(1):1-47. (Pubitemid 26026319)
85. Pistoia F, Sarà M. Gabapentin therapy for ocular opsoclonus-myoclonus restores eye movement communication in a patient with a locked-in syndrome. Neurorehabil Neural Repair. 2010;24(5):493-494.