Hypocupremia associated cytopenia and myelopathy: A national retrospective review

European Journal of Haematology

Volumn 90, Issue 1, 2013, Pages 1-9

  Gabreyes, Alemayehu A ^a   Abbasi, Hina Naz ^b   Forbes, Kirsten P ^b   Mcquaker, Grant ^a   Duncan, Andrew ^a   Morrison, Ian ^c  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b INSTITUTE OF NEUROLOGICAL SCIENCES   (United Kingdom)

^c NINEWELLS HOSPITAL   (United Kingdom)

Author keywords

Anaemia; Copper deficiency; Myelodysplasia; Neuropathy myelopathy; Zinc toxicity

Indexed keywords

ZINC;

ADOLESCENT; ADULT; AGED; BLOOD EXAMINATION; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; COPPER DEFICIENCY; CYTOPENIA; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPOCUPREMIA; MALE; MYELODYSPLASTIC SYNDROME; NEUTROPENIA; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REFRACTORY ANEMIA; RETROSPECTIVE STUDY; REVIEW; SPINAL CORD DISEASE; THROMBOCYTOPENIA; UNITED KINGDOM; ZINC BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANEMIA; BONE MARROW; COPPER; COPPER SULFATE; FEMALE; HEMATOLOGIC DISEASES; HUMANS; LYMPHOPENIA; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUTROPENIA; PANCYTOPENIA; RETROSPECTIVE STUDIES; SCOTLAND; SPINAL CORD; SPINAL CORD DISEASES; THROMBOCYTOPENIA; TREATMENT OUTCOME; YOUNG ADULT; ZINC;

EID: 84871186880     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/ejh.12020     Document Type: Review

References (29)

1. Stern BR, Solioz M, Krewski D, et al. Copper and Human Health: biochemistry, Genetics, and Strategies for Modeling Dose-Response Relationships. J Toxicol Environ Health B Crit Rev 2007;10:157-222.
2. Fiske DN, McCoy HE, Kitchens CS. Zinc-induced sideroblastic anemia: report of a case, review of the literature, and description of the hematologic syndrome. Am J Hematol 1994;46:147-50.
3. Halfdanarson TR, Kumar N, Li CY, Phyliky RL, Hogan WJ. Hematological manifestations of copper deficiency: a retrospective review. Eur J Haematol 2008;80:523-31.
4. Kumar N, Low PA. Myeloneuropathy and anemia due to copper malabsorption. J Neurol 2004;251:747-9.
5. Dunlap WM, James GW III, Hume DM. Anemia and neutropenia caused by copper deficiency. Ann Intern Med 1974;80:470-6.
6. Wasa M, Satani M, Tanano H, Nezu R, Takagi Y, Okada A. Copper deficiency with pancytopenia during total parenteral nutrition. JPEN J Parenter Enteral Nutr 1994;18:190-2.
7. Schleper B, Stuerenburg HJ. Copper deficiency-associated myelopathy in a 46-year-old woman. J Neurol 2001;248:705-6.
8. Kumar N, Gross JB Jr, Ahlskog JE. Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration. Neurology 2004;63:33-9.
9. Kumar N. Copper deficiency myelopathy (human sway- back). Mayo Clin Proc 2006;81:1371-84.
10. Jaiser SR, Winston GP. Copper deficiency myelopathy. J Neurol 2010;257:869-81.
11. Goodman BP, Chong BW, Patel AC. Copper deficiency myeloneuropathy resembling B12 deficiency: partial resolution of MRI findings with copper supplementation. AJNR 2006;27:2112-4.
12. Nagano T, Toyoda T, Tanabe H, et al. Clinical features of hematological disorders caused by copper deficiency during long-term enteral nutrition. Intern Med 2005;44:554-9.
13. Haddad AS, Subbiah V, Lichtin AE. Hypocupremia and bone marrow failure. Haematologica 2008;93:e1-5.
14. Tezvergil-Mutluay A, Carvalho RM, Pashley DH. Hyperzincemia from ingestion of denture adhesives. J Prosthet Dent 2010;103:380-3.
15. Irving JA, Mattman A, Lockitch G, et al. Element of caution: a case of reversible cytopenias associated with excessive zinc supplementation. CMAJ 2003;169:129-31.
16. Jenkitkasemwong S, Broderius M, Nam H, Prohaska JR, Knutson MD. Anemic Copper-Deficient Rats, but Not Mice, Display Low Hepcidin Expression and High Ferroportin Levels. J Nutr 2010;140:723-30.
17. Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, Gitschier J, Anderson GJ. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 1999;21:195-9.
18. Linder MC, Hazegh-Azam M. Copper biochemistry and molecular biology. Am J Clin Nutr 1996;63:797S-811S.
19. Bruce N. Ames, Hani Atamna, David W. Killilea. Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Mol Aspects Med 2005;26:363-78.
20. Bleackley Mark R, Wong Ann YK, Hudson David M, Wu Christopher H-Y, MacGillivray Ross TA. Blood iron homeostasis: newly discovered proteins and iron imbalance. Transfus Med Rev 2009;23:103-23.
21. Collins James F, Prohaska Joseph R, Knutson Mitchell D. Metabolic crossroads of iron and copper. Nutr Rev 2010;68:133-47.
22. Prodan CI, Bottomley SS, Holland NR, Lind SE. Relapsing hypocupraemic myelopathy requiring high-dose oral copper replacement. J Neurol Neurosurg Psychiatry 2006;77:1092-3.
23. Kumar N, Ahlskog JE, Klein CJ, Port JD. Imaging features of copper deficiency myelopathy: a study of 25 cases. Neuroradiology 2006;48:78-83.
24. Ravina B, Loevner LA, Bank W. MR Findings in subacute combined degeneration of the spinal cord: a case of reversible cervical myelopathy. AJR Am J Roentgenol 2000;174:863-5.
25. Rowin J, Lewis SL. Copper deficiency myeloneuropathy and pancytopenia secondary to overuse of zinc supplementation. J Neurol Neurosurg Psychiatry 2005;76:750-1.
26. Jung A, Marziniak M. Copper deficiency as a treatable cause of myelopathy. Der Nervenarzt. 2008;79:421-5.
27. Keen CL, Uriu-Hare JY, Hawk SN, Jankowski MA, Daston GP, Kwik-Uribe CL, Rucker RB. Effect of copper deficiency on prenatal development and pregnancy outcome. Am J Clin Nutr 1998;67:1003S-11S.
28. Winston GP, Jaiser SR. Copper deficiency myelopathy and subacute combined degeneration of the cord-why is the phenotype so similar? Med Hypotheses 2008;71:229-36.
29. Rossi L, Arciello M, Capo C, Rotilio G. Copper imbalance and oxidative stress in neurodegeneration. Ital J Biochem 2006;55:212-21.