Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele

Diabetes, Obesity and Metabolism

Volumn 15, Issue 1, 2013, Pages 91-95

  Faerch K ^a   Pilgaard, K ^b   Knop, F K ^b   Hansen, T ^c,d   Pedersen, O ^b,c,e,f   Jorgensen T ^b,d   Holst, J J ^b,c  

^a STENO DIABETES CENTER   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Capital Region   (Denmark)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^e HAGEDORN RESEARCH INSTITUTE   (Denmark)

^f AARHUS UNIVERSITY   (Denmark)

Author keywords

Endogenous glucose production; Glucagon like peptide 1; Glucose dependent insulinotropic polypeptide; Incretin hormones; Insulin secretion; Insulin sensitivity; TCF7L2

Indexed keywords

GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; INCRETIN; INSULIN; PANCREAS HORMONE; TRANSCRIPTION FACTOR 7 LIKE 2;

ADULT; AGE; ALLELE; CAUCASIAN; CONTROLLED STUDY; FEMALE; GENETIC RISK; GLUCOSE CLAMP TECHNIQUE; HORMONE RELEASE; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; LETTER; MAJOR CLINICAL STUDY; MALE; ORAL GLUCOSE TOLERANCE TEST; SEX DIFFERENCE;

EID: 84871179193     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2012.01675.x     Document Type: Letter

References (12)

1. Helgason A, Palsson S, Thorleifsson G et al. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 2007; 39: 218-225.
2. Lyssenko V, Lupi R, Marchetti P et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 2007; 117: 2155-2163.
3. Villareal DT, Robertson H, Bell GI et al. TCF7L2 variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action. Diabetes 2010; 59: 479-485.
4. Pilgaard K, Jensen CB, Schou JH et al. The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men. Diabetologia 2009; 52: 1298-1307.
5. Gjesing AP, Kjems LL, Vestmar MA et al. Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test. Diabetologia 2011; 54: 103-110.
6. Jørgensen T, Borch-Johnsen K, Thomsen TF, Ibsen H, Glümer C, Charlotta P. A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99 (1). Eur J Cardiovasc Prev Rehabil 2003; 10: 377-386.
7. Færch K, Vaag A, Holst J, Glümer C, Pedersen O, Borch-Johnsen K. Impaired fasting glycaemia vs impaired glucose tolerance: similar impairment of pancreatic alpha and beta cell function but differential roles of incretin hormones and insulin action. Diabetologia 2008; 51: 853-861.
8. Færch K, Brøns C, Alibegovic AC, Vaag A. The disposition index: adjustment for peripheral vs. hepatic insulin sensitivity? J Physiol 2010; 588: 759-764.
9. Schäfer SA, Tschritter O, Machicao F et al. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 2010; 50: 2443-2450.
10. Wegner L, Hussain MS, Pilgaard K et al. Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins. J Clin Endocrinol Metab 2008; 93: 4013-4019.
11. Klunder-Klunder M, Mejia-Benitez MA, Flores-Huerta S, Burguete-Garcia AI, Garcia-Mena J, Cruz M. rs12255372 Variant of TCF7L2 gene is protective for Obesity in Mexican Children. Arch Med Res 2011; 42: 495-501.
12. Holst JJ, Knop FK, Vilsboll T, Krarup T, Madsbad S. Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes. Diabetes Care 2011; 34: S251-257.