High mitotic activity of polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells

Journal of Biological Chemistry

Volumn 287, Issue 51, 2012, Pages 42812-42825

  Lera, Robert F ^a   Burkard, Mark E ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIPOLAR SPINDLES; CHEMICAL GENETICS; CHROMOSOME CONGRESSION; CHROMOSOME SEGREGATION; CLEAVAGE FURROW; GENERAL METHOD; GENOMIC INTEGRITY; HUMAN CELLS; HUMAN EPITHELIAL CELLS; KINASE ACTIVITY; LOW-TO-HIGH; MITOTIC ACTIVITY; PLEIOTROPIC FUNCTIONS; POLO-BOX DOMAIN; POLO-LIKE KINASE; PROTEIN KINASE;

CHROMOSOMES; CYTOLOGY; PHOSPHORYLATION; PLANTS (BOTANY); PROTEINS;

ENZYMES;

3 MB PP1; ADENOSINE TRIPHOSPHATE DERIVATIVE; BINDING PROTEIN; POLO LIKE KINASE 1; PROTEIN PBD; UNCLASSIFIED DRUG;

ACTIVITY THRESHOLD; ANAPHASE; ARTICLE; BIOLOGICAL MODEL; CARBOXY TERMINAL SEQUENCE; CELL AGING; CELL STRUCTURE; CHEMICAL GENETICS; CHEMICAL PARAMETERS; CHROMOSOME CONGRESSION; CHROMOSOME MISALIGNMENT; CHROMOSOME SEGREGATION; CHROMOSOMES AND CHROMOSOMAL PHENOMENA; CONTROLLED STUDY; CYTOKINESIS; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENETIC PARAMETERS; GENOMIC INTEGRITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INTRACELLULAR SIGNALING; METAPHASE; MITOSIS RATE; MITOSIS SPINDLE; MOLECULAR DYNAMICS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN FUNCTION;

ANAPHASE; CELL CYCLE PROTEINS; CELL LINE; CELL SURVIVAL; CHROMOSOME SEGREGATION; CHROMOSOMES, HUMAN; ENZYME ACTIVATION; EPITHELIAL CELLS; GENOME, HUMAN; HUMANS; INHIBITORY CONCENTRATION 50; MITOSIS; MITOTIC SPINDLE APPARATUS; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PYRIMIDINES; SUBSTRATE SPECIFICITY;

EID: 84871161766     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.412544     Document Type: Article

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