Overcoming autopsy barriers in pediatric cancer research

Pediatric Blood and Cancer

Volumn 60, Issue 2, 2013, Pages 204-209

  Alabran, Jennifer L ^a,b   Hooper, Jody E ^c   Hill, Melissa ^d   Smith, Sandra E ^e   Spady, Kimberlee K ^e   Davis, Lara E ^a,b   Peterson, Lauren S ^a,b   Malempati, Suman ^a,b   Ryan, Christopher W ^a,c   Acosta, Rae ^a,b   Spunt, Sheri L ^f   Keller, Charles ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d Northwest Sarcoma Foundation   (United States)

^e NONE   (United States)

^f UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Autopsy; Cancer; Childhood; End of life care; Research

Indexed keywords

ARTICLE; AUTOPSY; CANCER PATIENT; CANCER RESEARCH; CANCER TISSUE; CHILDHOOD CANCER; FAMILY ATTITUDE; GRIEF; HUMAN; INFORMED CONSENT; INTERVIEW; MAJOR CLINICAL STUDY; MEDICAL EXPERT; PATIENT ADVOCACY; PHYSICIAN; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ATTITUDE; AUTOPSY; BIOMEDICAL RESEARCH; CHILD; CHILD, PRESCHOOL; FAMILY; FEMALE; GRIEF; GUIDELINES AS TOPIC; HUMANS; INFANT; INFANT, NEWBORN; INTERVIEWS AS TOPIC; MALE; NEOPLASMS; PATIENT ADVOCACY; PEDIATRICS; YOUNG ADULT;

EID: 84871153939     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.24320     Document Type: Article

References (26)

1. National Institutes of Health. Cancer Incidence and Survival Among Children and Adolescents: United States Seer Program 1975-1995. Surveillance Research Program. http://seer.cancer.gov. Published 1999. Accessed January 25, 2011.
2. 2011 November 2, 2011 Canadian Cancer Society. http://www.cancer.ca Published 2011. Accessed November 2, 2011. http://www.cancer.ca/Canada-wide Accessed November 2, 2011.
3. Group AaYAOPR. U. S. Department of Health and Human Services. National Institutes of Health. Closing the gap: research and care imperatives for adolescents and young adults with cancer. Adolescents and Young Adults Oncology Progress Review Group. Published 2006. Accessed November 2011.
4. Donaldson SS, Laningham F, Fisher PG. Advances toward an understanding of brainstem gliomas. J Clin Oncol 2006; 24: 1266-1272.
5. Spunt SL, Vargas SO, Coffin CM, et al. The clinical, research, and social value of autopsy after any cancer death: A perspective from the Children's Oncology Group Soft Tissue Sarcoma Committee. Cancer 2012; 118: 3002-3009.
6. Angelini P, Hawkins C, Laperriere N, et al. Post mortem examinations in diffuse intrinsic pontine glioma: Challenges and chances. J Neurooncol 2011; 101: 75-81.
7. Zarghooni M, Bartels U, Lee E, et al. Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets. J Clin Oncol 2010; 28: 1337-1344.
8. Broniscer A, Baker JN, Baker SJ, et al. Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma. Cancer 2010; 116: 4632-4637.
9. Wu G, Broniscer A, McEachron TA, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet 2012; 44: 251-253.
10. Monje M, Mitra SS, Freret ME, et al. Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci USA 2011; 108: 4453-4458.
11. Paugh BS, Broniscer A, Qc C, et al. Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J Clin Oncol 2011; 29: 3999-4006.
12. Burton KW. Pioneers: A lasting gift. Science 2007; 315: 23. Science 2007: 23.
13. Hooper JE, Geller SA. Relevance of the autopsy as a medical tool: A large database of physician attitudes. Arch Pathol Lab Med 2007; 131: 268-274.
14. Burton JL, Underwood J. Clinical, educational, and epidemiological value of autopsy. Lancet 2007; 369: 1471-1480.
15. Charlton R. Autopsy and medical education: A review. J R Soc Med 1994; 87: 232-236.
16. Pastores SM, Dulu A, Voigt L, et al. Premortem clinical diagnoses and postmortem autopsy findings: Discrepancies in critically ill cancer patients. Crit Care 2007; 11: R48.
17. Shojania KG, Burton EC, McDonald KM, et al. Changes in rates of autopsy-detected diagnostic errors over time: A systematic review. JAMA 2003; 289: 2849-2856.
18. Rosenbaum GE, Burns J, Johnson J, et al. Autopsy consent practice at US teaching hospitals: Results of a national survey. Arch Intern Med 2000; 160: 374-380.
19. Oberlin O, Rey A, Lyden E, et al. Prognostic factors in metastatic rhabdomyosarcomas: Results of a pooled analysis from United States and European cooperative groups. J Clin Oncol 2008; 26: 2384-2389.
20. Stolman CJ, Castello F, Yorio M, et al. Attitudes of pediatricians and pediatric residents toward obtaining permission for autopsy. Arch Pediatr Adolesc Med 1994; 148: 843-847.
21. Grunberg SM, Sherrod A, Muellenbach R, et al. Analysis of physician attitudes concerning requests for autopsy. Cancer Invest 1994; 12: 463-468.
22. Sullivan J, Monagle P. Bereaved parents' perceptions of the autopsy examination of their child. Pediatrics 2011; 127: e1013-e1020.
23. Oppewal F, Meyboom-de Jong B. Family members' experiences of autopsy. Fam Pract 2001; 18: 304-308.
24. Millar T, Lerpiniere C, Walker R, et al. Postmortem tissue donation for research: A positive opportunity? Br J Nurs 2008; 17: 644-649.
25. Burton EC, Gurevitz, Stacy A. Religions and autopsy. 2010; http://emedicine.medscape.com/article/1705993-overview.
26. Embuscado EE, Laheru D, Ricci F, et al. Immortalizing the complexity of cancer metastasis: Genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. Cancer Biol Ther 2005; 4: 548-554.