Clomiphene citrate versus high doses of gonadotropins for in vitro fertilisation in women with compromised ovarian reserve: A randomised controlled non-inferiority trial

Reproductive Biology and Endocrinology

Volumn 10, Issue , 2012, Pages

  Ragni, Guido ^a   Levi Setti, Paolo E ^b   Fadini, Rubens ^c   Brigante, Claudio ^d   Scarduelli, Claudia ^a   Alagna, Federica ^a   Arfuso, Veronica ^b   Mignini Renzini, Mario ^c   Candiani, Massimo ^d   Paffoni, Alessio ^a   Somigliana, Edgardo ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^c Biogenesi Reproductive Medicine Centre   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Clomiphene citrate; IVF; Ovarian reserve; Poor responder

Indexed keywords

CLOMIFENE CITRATE; FOLLITROPIN; RECOMBINANT FOLLITROPIN; TRIPTORELIN;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; FOLLITROPIN BLOOD LEVEL; HUMAN; OOCYTE; OVARIAN RESERVE; RANDOMIZED CONTROLLED TRIAL;

ADULT; CLOMIPHENE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FERTILITY AGENTS, FEMALE; FERTILIZATION IN VITRO; GONADOTROPINS; HUMANS; INFERTILITY, FEMALE; OVULATION INDUCTION; PREGNANCY;

EID: 84871146622     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-10-114     Document Type: Article

References (17)

1. Loutradis D, Vomvolaki E, Drakakis P. Poor responder protocols for in-vitro fertilization: options and results. Curr Opin Obstet Gynecol 2008, 20:374-378. 10.1097/GCO.0b013e328305b9b8, 18660689.
2. Kyrou D, Kolibianakis EM, Venetis CA, Papanikolaou EG, Bontis J, Tarlatzis BC. How to improve the probability of pregnancy in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis. Fertil Steril 2009, 91:749-766. 10.1016/j.fertnstert.2007.12.077, 18639875.
3. Pandian Z, McTavish AR, Aucott L, Hamilton MP, Bhattacharya S. Interventions for 'poor responders' to controlled ovarian hyper stimulation (COH) in in-vitro fertilisation (IVF). Cochrane Database Syst Rev 2010, 1:CD004379.
4. Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L, . on behalf of the ESHRE working group on Poor Ovarian Response Definition ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod 2011, 26:1616-1624. 10.1093/humrep/der092, 21505041, on behalf of the ESHRE working group on Poor Ovarian Response Definition.
5. Ragni G, Chiaffarino F, Scarduelli C, Bonetti S, Nicolosi AE, Arnoldi M, Somigliana E. The clomiphene citrate challenge test (CCCT) in women with elevated basal FSH: biological significance and predictive value. Eur J Obstet Gynecol Reprod Biol 2008, 141:44-48. 10.1016/j.ejogrb.2008.06.009, 18676080.
6. Verberg MF, Macklon NS, Nargund G, Frydman R, Devroey P, Broekmans FJ, Fauser BC. Mild ovarian stimulation for IVF. Hum Reprod Update 2009, 15:13-29.
7. Ragni G, Somigliana E, Benedetti F, Paffoni A, Vegetti W, Restelli L, Crosignani PG. Damage to ovarian reserve associated with laparoscopic excision of endometriomas: a quantitative rather than a qualitative injury. Am J Obstet Gynecol 2005, 193:1908-1914. 10.1016/j.ajog.2005.05.056, 16325591.
8. Agenzia Italiana del Farmaco http://farmaco.agenziafarmaco.it/index.php.
9. Bollettino Ufficiale Regione Lombardia Bollettino Ufficiale Regione Lombardia, N. 50 S2 2010, Bollettino Ufficiale Regione Lombardia, http://www.regione.lombardia.it, Bollettino Ufficiale Regione Lombardia.
10. Italian ART register http://www.iss.it.
11. Ethics Committee of the American Society for Reproductive Medicine Fertility treatment when the prognosis is very poor or futile. Fertil Steril 2009, 92:1194-1197. Ethics Committee of the American Society for Reproductive Medicine.
12. Oudendijk JF, Yarde F, Eijkemans MJ, Broekmans FJ, Broer SL. The poor responder in IVF: is the prognosis always poor? A systematic review. Hum Reprod Update 2012, 18:1-11. 10.1093/humupd/dmr037, 21987525.
13. Ubaldi F, Rienzi L, Baroni E, Ferrero S, Iacobelli M, Minasi MG, Sapienza F, Romano S, Colasante A, Litwicka K, Greco E. Hopes and facts about mild ovarian stimulation. Reprod Biomed Online 2007, 14:675-681. 10.1016/S1472-6483(10)60667-0, 17579976.
14. Homburg R. Clomiphene citrate--end of an era? A mini-review. Hum Reprod 2005, 20:2043-2051. 10.1093/humrep/dei042, 15878925.
15. Ingerslev HJ, Højgaard A, Hindkjaer J, Kesmodel U. A randomized studycomparing IVF in the unstimulated cycle with IVF following clomiphene citrate. Hum Reprod 2001, 16:696-702. 10.1093/humrep/16.4.696, 11278221.
16. Broekmans FJ, Kwee J, Hendriks DJ, Mol BW, Lambalk CB. A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update 2006, 12:685-718. 10.1093/humupd/dml034, 16891297.
17. Crosignani PG, Somigliana E, . Intrauterine Insemination Study Group Effect of GnRH antagonists in FSH mildly stimulated intrauterine insemination cycles: a multicentre randomized trial. Hum Reprod 2007, 22:500-505. Intrauterine Insemination Study Group.