A double-blind, randomized, bilateral comparison of skin irritancy following application of the combination acne products clindamycin/tretinoin and benzoyl peroxide/adapalene

Journal of Drugs in Dermatology

Volumn 11, Issue 12, 2012, Pages 1422-1426

  Goreshi, Renato ^a   Samrao, Aman ^a,b   Ehst, Benjamin D ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPALENE PLUS BENZOYL PEROXIDE; CLINDAMYCIN; RETINOIC ACID;

ACNE VULGARIS; ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG TOLERABILITY; DRY SKIN; ERYTHEMA; FEMALE; HUMAN; MALE; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SKIN BURNING SENSATION; SKIN IRRITATION; SKIN WATER LOSS; TREATMENT OUTCOME;

ACNE VULGARIS; ADULT; ANTI-BACTERIAL AGENTS; BENZOYL PEROXIDE; CLINDAMYCIN; DERMATOLOGIC AGENTS; DIAGNOSTIC SELF EVALUATION; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; ERYTHEMA; FEMALE; HUMANS; IRRITANTS; KERATOLYTIC AGENTS; LINEAR MODELS; MALE; NAPHTHALENES; PRURITUS; SKIN; TRETINOIN; WATER LOSS, INSENSIBLE; YOUNG ADULT;

EID: 84871063962     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. White G. Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J Am Acad Dermatol. 1998;39(2 Pt 3):S34-S37. (Pubitemid 28367284)
2. Lehmann HP, Robinson KA, Andrews JS, Holloway V, Goodman SN. Acne therapy: a methodologic review. J Am Acad Dermatol. 2002;47(2):231-240.
3. James WD. Clinical practice. Acne. N Engl J Med. 2005;352(14):1463-1472.
4. Berger R, Rizer R, Barba A, et al. Tretinoin gel microspheres 0.04% versus 0.1% in adolescents and adults with mild to moderate acne vulgaris: a 12-week, multicenter, randomized, double-blind, parallel-group, phase IV trial. Clin Ther. 2007;29(6):1086-1097. (Pubitemid 47198892)
5. Thiboutot D, Gollnick H, Bettoli V, et al. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J Am Acad Dermatol. 2009;60(5 Suppl):S1-S50.
6. Andres P, Pernin C, Poncet M. Adapalene-benzoyl peroxide once-daily, fixed-dose combination gel for the treatment of acne vulgaris: a randomized, bilateral (split-face), dose-assessment study of cutaneous tolerability in healthy participants. Cutis. 2008;81(3):278-284.
7. Leyden JJ, Krochmal L, Yaroshinsky A. Two randomized, double-blind, controlled trials of 2219 subjects to compare the combination clindamycin/tretinoin hydrogel with each agent alone and vehicle for the treatment of acne vulgaris. J Am Acad Dermatol. 2006;54(1):73-81. (Pubitemid 41832461)
8. [No authors listed]. Clindamycin phosphate plus tretinoin 1.2%/0.025% gel (Ziana) for acne. Skinmed. 2007;6(3):135-136.
9. Tan JK. Adapalene 0.1% and benzoyl peroxide 2.5%: a novel combination for treatment of acne vulgaris. Skin Therapy Lett. 2009;14(6):4-5.
10. Leyden J, Wortzman M, Baldwin EK. Tolerability of clindamycin/tretinoin gel vs. tretinoin microsphere gel and adapalene gel. J Drugs Dermatol. 2009;8(4):383-388.
11. Fluhr JW, Feingold KR, Elias PM. Transepidermal water loss reflects permeability barrier status: validation in human and rodent in vivo and ex vivo models. Exp Dermatol. 2006;15(7):483-492. (Pubitemid 43834482)
12. Pinnagoda J, Tupker RA, Agner T, Serup J. Guidelines for transepidermal water loss (TEWL) measurement. A report from the Standardization Group of the European Society of Contact Dermatitis. Contact Dermatitis. 1990;22(3):164-178. (Pubitemid 20106155)
13. Hon KL, Wong KY, Leung TF, Chow CM, Ng PC. Comparison of skin hydration evaluation sites and correlations among skin hydration, transepidermal water loss, SCORAD index, Nottingham Eczema Severity Score, and quality of life in patients with atopic dermatitis. Am J Clin Dermatol. 2008;9(1):45-50.