Probiotics enhance the clearance of human papillomavirus-related cervical lesions: A prospective controlled pilot study

European Journal of Cancer Prevention

Volumn 22, Issue 1, 2013, Pages 46-51

  Verhoeven, Veronique ^a   Renard, Nathalie ^a   Makar, Amin ^b   Royen, Paul Van ^a   Bogers, John Paul ^a   Lardon, Filip ^a   Peeters, Marc ^a   Baay, Marc ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b MIDDELHEIM HOSPITAL   (Belgium)

Author keywords

cervical cancer; human papillomavirus; precancerous lesions; prevention; probiotics

Indexed keywords

PROBIOTIC AGENT; UNCLASSIFIED DRUG; VIRUS DNA; YAKULT;

ADULT; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; LACTOBACILLUS CASEI; MAJOR CLINICAL STUDY; NONHUMAN; PAPANICOLAOU TEST; PAPILLOMAVIRUS INFECTION; PILOT STUDY; POLYMERASE CHAIN REACTION; PRECANCER; PRIORITY JOURNAL; PROSPECTIVE STUDY; TREATMENT OUTCOME; UTERINE CERVIX CARCINOMA; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CYTOLOGY; VIRAL CLEARANCE; WART VIRUS;

ADULT; FEMALE; HUMANS; NEOPLASMS, SQUAMOUS CELL; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PILOT PROJECTS; PROBIOTICS; PROSPECTIVE STUDIES; UP-REGULATION; UTERINE CERVICAL NEOPLASMS; YOUNG ADULT;

EID: 84870988657     PISSN: 09598278     EISSN: 14735709     Source Type: Journal    
DOI: 10.1097/CEJ.0b013e328355ed23     Document Type: Article

References (35)

1. Ackermann S, Renner SP, Fasching PA, Poehls U, Bender HG, Beckmann MW (2005). Awareness of general and personal risk factors for uterine cancer among healthy women. Eur J Cancer Prev 14:519-524
2. Arbyn M, Benoy I, Simoens C, Bogers J, Beutels P, Depuydt C (2009). Prevaccination distribution of human papillomavirus types in women attending at cervical cancer screening in Belgium. Cancer Epidemiol Biomarkers Prev 18:321-330
3. Baay MF, Verhoeven V, Avonts D, Vermorken JB (2004). Risk factors for cervical cancer development: what do women think? Sex Health 1:145-149
4. Baay MF, Verhoeven V, Lambrechts HA, Pattyn GG, Lardon F, Van Royen P, Vermorken JB (2009). Feasibility of collecting self-sampled vaginal swabs by mail: quantity and quality of genomic DNA. Eur J Clin Microbiol Infect Dis 28:1285-1289
5. Bolton M, van der Straten A, Cohen CR (2008). Probiotics: Potential to prevent HIV and sexually transmitted infections in women. Sex Transm Dis 35: 214-225
6. Bosch FX, Lorincz A, Muñoz N, Meijer CJ, Shah KV (2002). The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 55: 244-265
7. Brismar-Wendel S, Froberg M, Hjerpe A, Andersson S, Johansson B (2009). Age-specific prevalence of HPV genotypes in cervical cytology samples with equivocal or low-grade lesions. Br J Cancer 101:511-517
8. Cassano N, Ferrari A, Fai D, Pettinato M, Pellè S, Del Brocco L (2011). Oral supplementation with a nutraceutical containing Echinacea, methionine and antioxidant/immunostimulating compounds in patients with cutaneous viral warts. G Ital Dermatol Venereol 146:191-195
9. Castellsagué X, Muñoz N (2003). Chapter 3: Cofactors in human papillomavirus carcinogenesis - role of parity, oral contraceptives, and tobacco smoking. J Natl Cancer Inst Monogr 31:20-28
10. De Roda Husman AM,Walboomers JM, van den Brule AJ, Meijer CJ, Snijders PJ (1995). The use of general primers GP5 and GP6 elongated at their 30 ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 76:1057-1062
11. Gillet E, Meys JF, Verstraelen H, Bosire C, De Sutter P, Temmerman M, Broeck DV (2011). Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: A meta-analysis. BMC Infect Dis 11:10
12. Guarisi R, Sarian LO, Hammes LS, Longatto-Filho A, Derchain SF, Roteli-Martins C, et al. (2009). Smoking worsens the prognosis of mild abnormalities in cervical cytology. Acta Obstet Gynecol Scand 88:514-520
13. Hogewoning CJ, Bleeker MC, van den Brule AJ, Voorhorst FJ, Snijders PJ, Berkhof J, et al. (2003). Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: A randomized clinical trial. Int J Cancer 107:811-816
14. Jacobs MV, Snijders PJ, van den Brule AJ, Meijer CJ, Snijders PJ (1997). A general primer GP5+ /GP6(+)-mediated PCR-enzyme immunoassay method for rapid detection of 14 high-risk and 6 low-risk human papillomavirus genotypes in cervical scrapings. J Clin Microbiol 35:791-795
15. Kjaer SK, Engholm G, Dahl C, Bock JE (1996). Case-control study of risk factors for cervical squamous cell neoplasia in Denmark. IV: Role of smoking habits. Eur J Cancer Prev 5:359-365
16. Lippman SA, Sucupira MC, Jones HE, Luppi CG, Palefsky J, van de Wijgert JH, et al. (2010). Prevalence, distribution and correlates of endocervical human papillomavirus types in Brazilian women. Int J STD AIDS 21:105-109
17. MacPhee RA, Hummelen R, Bisanz JE, Miller WL, Reid G (2010). Probiotic strategies for the treatment and prevention of bacterial vaginosis. Expert Opin Pharmacother 11:2985-2995
18. Maucort-Boulch D, Plummer M, Castle PE, Demuth F, Safaeian M,Wheeler CM, Schiffman M (2010). Predictors of human papillomavirus persistence among women with equivocal or mildly abnormal cytology. Int J Cancer 126: 684-691
19. Murthy NS, Mathew A (2000). Risk factors for pre-cancerous lesions of the cervix. Eur J Cancer Prev 9:5-14
20. Muñoz N, Franceschi S, Bosetti C, Moreno V, Herrero R, Smith JS, et al. (2002). Role of parity and human papillomavirus in cervical cancer: The IARC multicentric case-control study. Lancet 359:1093-1101
21. Nanno M, Kato I, Kobayashi T, Shida K (2001). Biological effects of probiotics: what impact does Lactobacillus casei Shirota have on us? Int J Immunopathol Pharmacol 24:S45-S50
22. Reid G, Dols J, Miller W (2009). Targeting the vaginal microbiota with probiotics as a means to counteract infections. Curr Opin Clin Nutr Metab Care 12:583-587
23. Richardson H, Abrahamowicz M, Tellier PP, Kelsall G, du Berger R, Ferenczy A, et al. (2005). Modifiable risk factors associated with clearance of typespecific cervical human papillomavirus infections in a cohort of university students. Cancer Epidemiol Biomarkers Prev 14:1149-1156
24. Rousseau MC, Franco EL, Villa LL, Sobrinho JP, Termini L, Prado JM, Rohan TE (2000). A cumulative case-control study of risk factor profiles for oncogenic and nononcogenic cervical human papillomavirus infections. Cancer Epidemiol Biomarkers Prev 9:469-476
25. Sedjo RL, Inserra P, Abrahamsen M, Harris RB, Roe DJ, Baldwin S, Giuliano AR (2002). Human papillomavirus persistence and nutrients involved in the methylation pathway among a cohort of young women. Cancer Epidemiol Biomarkers Prev 11:353-359
26. Spurbeck R, Arvidson CG (2011). Lactobacilli at the front line of defence against vaginally acquired infections. Future Microbiol 6:567-582
27. Stoler MH, Schiffman M (2001). Atypical Squamous Cells of Undetermined Significance-Low-grade Squamous Intraepithelial Lesion Triage Study (ALTS) Group. Interobserver reproducibility of cervical cytologic and histologic interpretations: Realistic estimates from the ASCUS-LSIL Triage Study. JAMA 285:1500-1505
28. Syrjanen K (2007). Mechanisms and predictors of high-risk human papillomavirus clearance in the uterine cervix. Eur J Gynaecol Oncol 28:337-351
29. Syrjänen K, Shabalova I, Petrovichev N, Kozachenko V, Zakharova T, Pajanidi J, et al. (2006). Oral contraceptives are not an independent risk factor for cervical intraepithelial neoplasia or high-risk human papillomavirus infections. Anticancer Res 26:4729-4740
30. Syrjänen S, Shabalova IP, Petrovichev N, Kozachenko VP, Zakharova T, Pajanidi A, et al. (2005). Clearance of high-risk human papillomavirus (HPV) DNA and PAP smear abnormalities in a cohort of women subjected to HPV screening in the New Independent States of the former Soviet Union (the NIS cohort study). Eur J Obstet Gynecol Reprod Biol 119:219-227
31. Van Baarlen P, Troost F, van der Meer C, Hooiveld G, Boekschoten M, Brummer RJ, Kleerebezem M (2011). Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways. Proc Natl Acad Sci USA 108:4562-4569
32. Van Puyenbroeck K, Hens N, Coenen S, Michiels B, Beunckens C, Molenberghs G, et al. (2012). Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: A randomized, doubleblind, placebo-controlled trial in healthy elderly nursing home residents. Am J Clin Nutr 95:1165-1171
33. Verbruggen BS, Boon ME, van Schie MA, Wijsman-Grootendorst R, Kok LP (2006). Dysbacteriosis in silver-stained cervical smears of Dutch-Moroccan immigrants: HPV infection and preneoplasia. Diagn Cytopathol 34:56-61
34. Verhoeven V, Baay MF, Baay PE, Lardon F, Van Royen P, Vermorken JB (2010). Everything you always wanted to know about HPV (but could not ask your doctor). Patient Educ Couns 81:101-105
35. Wang SS, Gonzalez P, Yu K, Porras C, Li Q, Safaeian M, et al. (2010). Common genetic variants and risk for HPV persistence and progression to cervical cancer. PLoS One 5:e8667