Inhibitory effects of metachromins L-Q and its related analogs against receptor tyrosine kinases EGFR and HER2

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 117-118

  Takahashi, Yohei ^a   Kubota, Takaaki ^a   Yamamoto, Sunao ^a   Kobayashi, Jun'Ichi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

EGFR; HER2; Marine sponge; Metachromins; Spongia sp.

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; METACHROMIN A; METACHROMIN C; METACHROMIN DERIVATIVE; METACHROMIN L; METACHROMIN M; METACHROMIN N; METACHROMIN O; METACHROMIN P; METACHROMIN Q; NAKIJIQUINONE C8; SESQUITERPENOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; OKINAWAN; SPONGE (PORIFERA);

CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

SPONGIA;

EID: 84870984177     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.001     Document Type: Article

References (8)

1. J. Schlessinger Science 306 2004 1506
2. C.L. Arteaga J. Clin. Oncol. 19 2001 32S
3. J.E. Dowell, and J.D. Minna Nat. Clin. Pract. Oncol. 1 2004 2
4. S. Temam, H. Kawaguchi, A.K. El-Naggar, J. Jelinek, H. Tang, D.D. Liu, W. Lang, J.P. Issa, J.J. Lee, and L. Mao J. Clin. Oncol. 25 2007 2164
5. Y. Takahashi, T. Kubota, J. Fromont, and J. Kobayashi Tetrahedron 63 2007 8770
6. M. Ishibashi, Y. Ohizumi, J.-F. Cheng, H. Nakamura, Y. Hirata, T. Sasaki, and J. Kobayashi J. Org. Chem. 53 1988 2855
7. J. Kobayashi, T. Murayama, Y. Ohizumi, H. Ohta, S. Nozoe, and T. Sasaki J. Nat. Prod. 52 1989 1173
8. J. Kobayashi, T. Madono, and H. Shigemori Tetrahedron 51 1995 10867