Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 351-354

  Cai, Chaozhong ^a   Kang, Fu An ^a   Hou, Cuifen ^a   O'Neill, John C ^a   Opas, Evan ^a   McKenney, Sandra ^a   Johnson, Dana ^a   Sui, Zhihua ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

1,3 Dipolar cycloaddition; CCR2; Fused bicycle ring

Indexed keywords

2 AMINOOCTAHYDROCYCLOPENTALEN 3A CARBOXAMIDE DERIVATIVE; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; MOLECULAR SCAFFOLD; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOG; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HAPLORHINI; INFLAMMATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AMIDES; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CYCLOPENTANES; DISEASE MODELS, ANIMAL; DOGS; HALF-LIFE; HAPLORHINI; HUMANS; INFLAMMATION; MICE; MICE, KNOCKOUT; PROTEIN BINDING; PYRIDINES; RECEPTORS, CCR2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

CANIS FAMILIARIS; MUS;

EID: 84870981267     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.069     Document Type: Article

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