Simultaneous enantiomeric determination ofMDMA and its phase i and phase IImetabolites in urine by liquid chromatography-tandem mass spectrometry with chiral derivatization

Analytical and Bioanalytical Chemistry

Volumn 404, Issue 8, 2012, Pages 2427-2435

  Nakanishi, Keiko ^a   Katagi, Munehiro ^a   Zaitsu, Kei ^a   Shima, Noriaki ^a   Kamata, Hiroe ^a   Miki, Akihiro ^a   Kato, Hajime ^b   Harada, Ken Ichi ^c   Tsuchihashi, Hitoshi ^d   Suzuki, Koichi ^d  

^a Chuo ward   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^c MEIJO UNIVERSITY   (Japan)

^d OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Enantiomer; Liquid chromatography tandem mass spectrometry; Marfey's reagent; MDMA; Phase II metabolite

Indexed keywords

3 ,4-METHYLENEDIOXYMETHAMPHETAMINE; ANALYTES; ANALYTICAL PROCEDURE; AQUEOUS MEDIA; CHROMATOGRAPHIC SEPARATIONS; DERIVATIZATIONS; DESIGNER DRUGS; DIASTEREOMERS; ENANTIOMERIC DETERMINATION; GLUCURONIDES; LC-ESI-MS/MS; LIMITS OF DETECTION; LINEAR CALIBRATION CURVE; LINEAR GRADIENT ELUTION; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MARFEY'S REAGENT; MDMA; MULTIPLE-REACTION MONITORING MODES; OCTADECYLSILANE; PHASE I; PHASE II; REPRODUCIBILITIES; SIMULTANEOUS DETERMINATIONS; TANDEM MASS SPECTROMETRY;

BIOMOLECULES; BODY FLUIDS; CHIRALITY; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; ENANTIOMERS; MASS SPECTROMETRY; METABOLITES;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

3,4 METHYLENEDIOXYAMPHETAMINE;

ARTICLE; CHEMICAL STRUCTURE; HUMAN; LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY; QUALITY CONTROL; STANDARD; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; URINALYSIS; URINE; VALIDATION STUDY;

3,4-METHYLENEDIOXYAMPHETAMINE; CHROMATOGRAPHY, LIQUID; HUMANS; MOLECULAR STRUCTURE; QUALITY CONTROL; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; URINALYSIS;

EID: 84870941964     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6385-9     Document Type: Article

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