-
1
-
-
68549097002
-
International randomized study of interferon versus STI571 (IRIS) 7-year follow-up: sustained survival, low rate of transformation and increased rate of major molecular response (MMR) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib (IM)
-
abstract 186].
-
O'Brien SG, Guilhot F, Goldman JM, et al. International randomized study of interferon versus STI571 (IRIS) 7-year follow-up: sustained survival, low rate of transformation and increased rate of major molecular response (MMR) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib (IM). Blood 2008; 112(11): 76[abstract 186].
-
(2008)
Blood
, vol.112
, Issue.11
, pp. 76
-
-
O'Brien, S.G.1
Guilhot, F.2
Goldman, J.M.3
-
2
-
-
77949767505
-
International randomized study of interferon vs STI571 (IRIS) 8-year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib
-
abstract 1126].
-
Deininger M, O'Brien SG, Guilhot F, et al. International randomized study of interferon vs STI571 (IRIS) 8-year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib. Blood 2009; 114(22): 462[abstract 1126].
-
(2009)
Blood
, vol.114
, Issue.22
, pp. 462
-
-
Deininger, M.1
O'Brien, S.G.2
Guilhot, F.3
-
3
-
-
73349122639
-
Chronic myeloid leukemia: an update of concepts and management recommendations of european LeukemiaNet
-
Baccarani M, Cortes J, Pane F, et al. Chronic myeloid leukemia: an update of concepts and management recommendations of european LeukemiaNet. J Clin Oncol 2009; 27(35): 6041-6051.
-
(2009)
J Clin Oncol
, vol.27
, Issue.35
, pp. 6041-6051
-
-
Baccarani, M.1
Cortes, J.2
Pane, F.3
-
4
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293(5531): 876-880.
-
(2001)
Science
, vol.293
, Issue.5531
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
5
-
-
77952467377
-
Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib
-
Marin D, Bazeos A, Mahon FX, et al. Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol 2010; 28: 2381-2388.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2381-2388
-
-
Marin, D.1
Bazeos, A.2
Mahon, F.X.3
-
6
-
-
1542608328
-
Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients
-
Peng B, Hayes M, Resta D, et al. Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients. J Clin Oncol 2004; 22(5): 935-942.
-
(2004)
J Clin Oncol
, vol.22
, Issue.5
, pp. 935-942
-
-
Peng, B.1
Hayes, M.2
Resta, D.3
-
7
-
-
19444376971
-
Drug metabolism and variability among patients in drug response
-
Wilkinson GR. Drug metabolism and variability among patients in drug response. N Engl J Med 2005; 352(21): 2211-2221.
-
(2005)
N Engl J Med
, vol.352
, Issue.21
, pp. 2211-2221
-
-
Wilkinson, G.R.1
-
8
-
-
24344482346
-
Clinical pharmacokinetics of imatinib
-
Peng B, Lloyd P, Schran H. Clinical pharmacokinetics of imatinib. Clin Pharmacokinet 2005; 44(9): 879-94.
-
(2005)
Clin Pharmacokinet
, vol.44
, Issue.9
, pp. 879-894
-
-
Peng, B.1
Lloyd, P.2
Schran, H.3
-
9
-
-
52649177063
-
Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia
-
Dulucq S, Bouchet S, Turcq B, et al. Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood 2008; 112(5): 2024-2027.
-
(2008)
Blood
, vol.112
, Issue.5
, pp. 2024-2027
-
-
Dulucq, S.1
Bouchet, S.2
Turcq, B.3
-
10
-
-
77954936879
-
Functional activity of the OCT-1 protein is predictive of long-term outcome in patients with chronic-phase chronic myeloid leukemia treated with imatinib
-
White DL, Dang P, Engler J, et al. Functional activity of the OCT-1 protein is predictive of long-term outcome in patients with chronic-phase chronic myeloid leukemia treated with imatinib. J Clin Oncol 2010; 28(16): 2761-2767.
-
(2010)
J Clin Oncol
, vol.28
, Issue.16
, pp. 2761-2767
-
-
White, D.L.1
Dang, P.2
Engler, J.3
-
11
-
-
68549084355
-
CML patients with low OCT-1 activity achieve better molecular responses on high dose imatinib than on standard dose. those with high OCT-1 activity have excellent responses on either dose: a TOPS correlative study
-
abstract 3187].
-
White DL, Saunders VA, Dang P. CML patients with low OCT-1 activity achieve better molecular responses on high dose imatinib than on standard dose. those with high OCT-1 activity have excellent responses on either dose: a TOPS correlative study. Blood 2008; 112(11): 1093-1094[abstract 3187].
-
(2008)
Blood
, vol.112
, Issue.11
, pp. 1093-1094
-
-
White, D.L.1
Saunders, V.A.2
Dang, P.3
-
12
-
-
33745085275
-
OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib
-
White DL, Saunders VA, Dang P, et al. OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. Blood 2006; 108(2): 697-704.
-
(2006)
Blood
, vol.108
, Issue.2
, pp. 697-704
-
-
White, D.L.1
Saunders, V.A.2
Dang, P.3
-
13
-
-
79952179437
-
Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib
-
Haouala A, Widmer N, Duchosal MA, et al. Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib. Blood 2011; 117(8): e75-87.
-
(2011)
Blood
, vol.117
, Issue.8
-
-
Haouala, A.1
Widmer, N.2
Duchosal, M.A.3
-
14
-
-
33745698739
-
Disposition of imatinib and its metabolite CGP74588 in a patient with chronic myelogenous leukemia and short-bowel syndrome
-
Beumer JH, Natale JJ, Lagattuta TF, et al. Disposition of imatinib and its metabolite CGP74588 in a patient with chronic myelogenous leukemia and short-bowel syndrome. Pharmacotherapy 2006; 26(7): 903-907.
-
(2006)
Pharmacotherapy
, vol.26
, Issue.7
, pp. 903-907
-
-
Beumer, J.H.1
Natale, J.J.2
Lagattuta, T.F.3
-
15
-
-
43249083718
-
Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study
-
Larson RA, Druker BJ, Guilhot FA, et al. Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study. Blood 2008; 111(8): 4022-4028.
-
(2008)
Blood
, vol.111
, Issue.8
, pp. 4022-4028
-
-
Larson, R.A.1
Druker, B.J.2
Guilhot, F.A.3
-
16
-
-
34147174980
-
Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
-
Picard S, Titier K, Etienne G, et al. Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood 2007; 109(8): 3496-3499.
-
(2007)
Blood
, vol.109
, Issue.8
, pp. 3496-3499
-
-
Picard, S.1
Titier, K.2
Etienne, G.3
-
17
-
-
71849114712
-
Therapeutic drug monitoring of imatinib and impact on clinical decision making
-
abstract 4820].
-
Blasdel C, Wang Y, Lagattuta T, et al. Therapeutic drug monitoring of imatinib and impact on clinical decision making. Blood 2006; 108(11): 290b[abstract 4820].
-
(2006)
Blood
, vol.108
, Issue.11
-
-
Blasdel, C.1
Wang, Y.2
Lagattuta, T.3
-
18
-
-
0038359665
-
Liquid chromatographic-mass spectrometric assay for quantitation of imatinib and its main metabolite (CGP 74588) in plasma
-
Parise RA, Ramanathan RK, Hayes MJ, et al. Liquid chromatographic-mass spectrometric assay for quantitation of imatinib and its main metabolite (CGP 74588) in plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2003; 791(1-2): 39-44.
-
(2003)
J Chromatogr B Analyt Technol Biomed Life Sci.
, vol.791
, Issue.1-2
, pp. 39-44
-
-
Parise, R.A.1
Ramanathan, R.K.2
Hayes, M.J.3
-
19
-
-
37049028176
-
Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity
-
White DL, Saunders VA, Dang P, et al. Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity. Blood 2007; 110(12): 4064-4072.
-
(2007)
Blood
, vol.110
, Issue.12
, pp. 4064-4072
-
-
White, D.L.1
Saunders, V.A.2
Dang, P.3
-
20
-
-
9444282642
-
Active transport of imatinib into and out of cells: implications for drug resistance
-
Thomas J, Wang L, Clark RE, et al. Active transport of imatinib into and out of cells: implications for drug resistance. Blood 2004; 104(12): 3739-3745.
-
(2004)
Blood
, vol.104
, Issue.12
, pp. 3739-3745
-
-
Thomas, J.1
Wang, L.2
Clark, R.E.3
-
21
-
-
77953723830
-
24months update of the TOPS study: a phase III, randomized, open-label study of 400mg/d (SD-IM) versus 800mg/d (HD-IM) of imatinib mesylate (IM) in patients (pts) with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase (CML-CP)
-
abstract 337].
-
Baccarani M, Druker BJ, Cortes-Franco J, et al. 24months update of the TOPS study: a phase III, randomized, open-label study of 400mg/d (SD-IM) versus 800mg/d (HD-IM) of imatinib mesylate (IM) in patients (pts) with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase (CML-CP). Blood 2009; 114(22): 142[abstract 337].
-
(2009)
Blood
, vol.114
, Issue.22
, pp. 142
-
-
Baccarani, M.1
Druker, B.J.2
Cortes-Franco, J.3
-
22
-
-
52449100460
-
Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications
-
Hiwase DK, Saunders V, Hewett D, et al. Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications. Clin Cancer Res 2008; 14(12): 3881-3888.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.12
, pp. 3881-3888
-
-
Hiwase, D.K.1
Saunders, V.2
Hewett, D.3
|