Blue-green algae or cyanobacteria in the intestinal micro-flora may produce neurotoxins such as Beta-N-Methylamino-l-Alanine (BMAA) which may be related to development of amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson-Dementia-Complex in humans and Equine Motor Neuron Disease in Horses

Medical Hypotheses

Volumn 80, Issue 1, 2013, Pages 103-

  Brenner, Steven R ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 METHYLAMINOPROPIONIC ACID; ALPHA TOCOPHEROL; ANATOXIN A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SAXITOXIN;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; BACTERIAL GROWTH; CYANOBACTERIUM; DISEASE COURSE; INTESTINE FLORA; LETTER; MALNUTRITION; MOTOR NEURON DISEASE; NERVOUS SYSTEM; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE;

ALZHEIMER DISEASE; AMINO ACIDS, DIAMINO; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CYANOBACTERIA; HORSE DISEASES; HORSES; HUMANS; METAGENOME; MODELS, BIOLOGICAL; MOTOR NEURON DISEASE; NEUROTOXINS; PARKINSON DISEASE; SUPRANUCLEAR PALSY, PROGRESSIVE;

CHLOROPHYTA; CYANOBACTERIA; EQUIDAE;

EID: 84870921029     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.10.010     Document Type: Letter

References (4)

1. Banack S.A., Caller T.A., Stommel E.W. The cyanobacteria derived toxin beta-N-methylamino-l-alanine and amyotrophic lateral sclerosis. Toxins (Basel) 2010, 2(12):2837-2850. http://dx.doi.org/110.3390/toxins2122837.
2. Mohammed H.O., Divers T.J., Summers B.A. De Lahunta A vitamin e deficiency and risk of equine motor neuron disease. Acta Vet Scand 2007, 49:17.
3. Ley R.E., Peterson D.A., Gordon J.I. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 2006, 124:837-848.
4. Shepherd M.L., Swecker W.S., Jensen R.V., Ponder M.A. Characterization of the fecal bacterial communities of forage-fed horses by pyrosequencing of 16S rRNA V4 gene amplicons. FEMS Microbiol Lett 2012, 326:62-68.