Chromosomal aberrations in peripheral blood lymphocytes in patients with newly diagnosed celiac and Crohn's disease

European Journal of Gastroenterology and Hepatology

Volumn 25, Issue 1, 2013, Pages 22-27

  Hojsak, Iva ^a   Gagro, Alenka ^a,b   Petković, Iskra ^a   Mišak, Zrinjka ^a   Kolaček, Sanja ^a  

^a Alergologiju I Reumatologiju S Klini kom Imunologijom   (Croatia)

^b INSTITUTE OF IMMUNOLOGY   (Croatia)

Author keywords

Celiac disease; Children; Chromosomal aberrations; Crohn's disease; Intraepithelial lymphocytes

Indexed keywords

CD103 ANTIGEN; CD8 ANTIGEN; INTEGRIN;

ARTICLE; CELIAC DISEASE; CHILD; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; ENTEROPATHY ASSOCIATED T CELL LYMPHOMA; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MALE; METAPHASE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD;

ANALYSIS OF VARIANCE; ANTIGENS, CD; ANTIGENS, CD3; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELIAC DISEASE; CELLS, CULTURED; CHILD; CHROMOSOME ABERRATIONS; CROHN DISEASE; CYTOGENETIC ANALYSIS; ENTEROPATHY-ASSOCIATED T-CELL LYMPHOMA; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; INTEGRIN ALPHA CHAINS; MALE; PROSPECTIVE STUDIES;

EID: 84870919457     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/MEG.0b013e328359526c     Document Type: Article

References (43)

1. Di Sabatino A, Corazza GR. Coeliac disease. Lancet 2009; 373: 1480-1493.
2. Heap GA, van Heel DA. The genetics of chronic inflammatory diseases. Hum Mol Genet 2009; 18:R101-R106.
3. Festen EA, Goyette P, Green T, Boucher G, Beauchamp C, Trynka G, et al. A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease. PLoS Genet 2011; 7:e1001283.
4. Askling J, Linet M, Gridley G, Halstensen TS, Ekstrom K, Ekbom A. Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. Gastroenterology 2002; 123:1428-1435.
5. Lewis JD, Bilker WB, Brensinger C, Deren JJ, Vaughn DJ, Strom BL. Inflammatory bowel disease is not associated with an increased risk of lymphoma. Gastroenterology 2001; 121:1080-1087.
6. Bernstein CN, Blanchard JF, Kliewer E, Wajda A. Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer 2001; 91:854-862.
7. Al-Toma A, Verbeek WH, Hadithi M, von Blomberg BM, Mulder CJ. Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: retrospective evaluation of single-centre experience. Gut 2007; 56: 1373-1378.
8. Catassi C, Bearzi I, Holmes GK. Association of celiac disease and intestinal lymphomas and other cancers. Gastroenterology 2005; 128:S79-S86.
9. Biagi F, Luinetti O, Campanella J, Klersy C, Zambelli C, Villanacci V, et al. Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease? J Clin Pathol 2004; 57:835-839.
10. Camarero C, Leon F, Sanchez L, Asensio A, Roy G. Age-related variation of intraepithelial lymphocytes subsets in normal human duodenal mucosa. Dig Dis Sci 2007; 52:685-691.
11. Agace WW, Higgins JM, Sadasivan B, Brenner MB, Parker CM. T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines. Curr Opin Cell Biol 2000; 12:563-568.
12. Daum S, Cellier C, Mulder CJ. Refractory coeliac disease. Best Pract Res Clin Gastroenterol 2005; 19:413-424.
13. Bagdi E, Diss TC, Munson P, Isaacson PG. Mucosal intra-epithelial lymphocytes in enteropathy-associated T-cell lymphoma, ulcerative jejunitis, and refractory celiac disease constitute a neoplastic population. Blood 1999; 94:260-264.
14. Van deWater JM, Cillessen SA, Visser OJ, Verbeek WH, Meijer CJ, Mulder CJ. Enteropathy associated T-cell lymphoma and its precursor lesions. Best Pract Res Clin Gastroenterol 2010; 24:43-56.
15. Tack GJ, Verbeek WH, van deWater JM, von Blomberg BM, Bhola SL, Ylstra B, et al. Phenotypic and genomic analysis of an exceptional case of enteropathy associated T-cell lymphoma. Leuk Res 2010; 34:e183-e189.
16. Verkarre V, Asnafi V, Lecomte T, Patey Mariaud-de Serre N, Leborgne M, Grosdidier E, et al. Refractory coeliac sprue is a diffuse gastrointestinal disease. Gut 2003; 52:205-211.
17. Verbeek WH, von Blomberg BM, Coupe VM, Daum S, Mulder CJ, Schreurs MW. Aberrant T-lymphocytes in refractory coeliac disease are not strictly confined to a small intestinal intraepithelial localization. Cytometry B Clin Cytom 2009; 76:367-374.
18. Cellier C, Delabesse E, Helmer C, Patey N, Matuchansky C, Jabri B, et al. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet 2000; 356:203-208.
19. Liu H, Brais R, Lavergne-Slove A, Jeng Q, Payne K, Ye H, et al. Continual monitoring of intraepithelial lymphocyte immunophenotype and clonality is more important than snapshot analysis in the surveillance of refractory coeliac disease. Gut 2010; 59:452-460.
20. Fundia AF, Gonzalez Cid MB, Bai J, Gomez JC, Mazure R, Vazquez H, et al. Chromosome instability in lymphocytes from patients with celiac disease. Clin Genet 1994; 45:57-61.
21. Fundia A, Gomez JC, Maurino E, Boerr L, Bai JC, Larripa I, Slavutsky I. Chromosome instability in untreated adult celiac disease patients. Acta Paediatr Suppl 1996; 412:82-84.
22. Fundia AF, Cottliar AS, La Motta G, Crivelli A, Gomez JC, Slavutsky IR, Larripa IB. Analysis of genomic instability in adult-onset celiac disease patients by microsatellite instability and loss of heterozygosis. Eur J Gastroenterol Hepatol 2008; 20:1159-1166.
23. Kolacek S, Petkovic I, Booth IW. Chromosome aberrations in coeliac and non-coeliac enteropathies. Arch Dis Child 1998; 78:466-468.
24. Kolacek S, Jadresin O, Petkovic I, Misak Z, Sonicki Z, Booth IW. Gluten-free diet has a beneficial effect on chromosome instability in lymphocytes of children with coeliac disease. J Pediatr Gastroenterol Nutr 2004; 38:177-180.
25. Kang MH, Genser D, Elmadfa I. Increased sister chromatid exchanges in peripheral lymphocytes of patients with Crohn's disease. Mutat Res 1997; 381:141-148.
26. Emerit I, Emerit J, Levy A, Keck M. Chromosomal breakage in Crohn's disease: anticlastogenic effect of D-penicillamine and L-cysteine. Hum Genet 1979; 50:51-57.
27. Danalioglu A. The frequency of sister chromatid exchanges in patients with Crohn's disease and the effect of therapy with 'anti-tumor necrosis factor' on this frequency. Hepatogastroenterology 2009; 56:729-733.
28. Yan B, Peng Y, Li CY. Molecular analysis of genetic instability caused by chronic inflammation. Methods Mol Biol 2009; 512:15-28.
29. Nilsen EM, Lundin KE, Krajci P, Scott H, Sollid LM, Brandtzaeg P. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma. Gut 1995; 37: 766-776.
30. Peddie CM, Wolf CR, McLellan LI, Collins AR, Bowen DT. Oxidative DNA damage in CD34 + myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor-alpha concentration. Br J Haematol 1997; 99:625-631.
31. Szaflarska-Poplawska A, Siomek A, Czerwionka-Szaflarska M, Gackowski D, Rozalski R, Guz J, et al. Oxidatively damaged DNA/oxidative stress in children with celiac disease. Cancer Epidemiol Biomarkers Prev 2010; 19:1960-1965.
32. IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. Inflammatory bowel disease in children and adolescents: recommendations for diagnosis - the Porto criteria. J Pediatr Gastroenterol Nutr 2005; 41:1-7.
33. Martin-Arruti M, Irastorza I, de Prado E, Martin-Sanchez E, Martin-Guerrero I, Ballesteros J, et al. Chromosome instability in lymphocytes of children with coeliac disease. J Pediatr Gastroenterol Nutr 2009; 49:143-146.
34. Duker NJ. Chromosome breakage syndromes and cancer. Am J Med Genet 2002; 115:125-129.
35. Vodicka P, Polivkova Z, Sytarova S, Demova H, Kucerova M, Vodickova L, et al. Chromosomal damage in peripheral blood lymphocytes of newly diagnosed cancer patients and healthy controls. Carcinogenesis 2010; 31:1238-1241.
36. Ludvigsson JF, Montgomery SM, Ekbom A, Brandt L, Granath F. Smallintestinal histopathology and mortality risk in celiac disease. JAMA 2009; 302:1171-1178.
37. Solaymani-Dodaran M, West J, Logan RF. Long-term mortality in people with celiac disease diagnosed in childhood compared with adulthood: a population-based cohort study. Am J Gastroenterol 2007; 102: 864-870.
38. Isaacson PG, Du MQ. Gastrointestinal lymphoma: where morphology meets molecular biology. J Pathol 2005; 205:255-274.
39. Verkarre V, Romana SP, Cellier C, Asnafi V, Mention JJ, Barbe U, et al. Recurrent partial trisomy 1q22-q44 in clonal intraepithelial lymphocytes in refractory celiac sprue. Gastroenterology 2003; 125:40-46.
40. Tack GJ, van Wanrooij RL, Langerak AW, Tjon JM, von Blomberg BM, Heideman DA, et al. Origin and immunophenotype of aberrant IEL in RCDII patients. Mol Immunol 2012; 50:262-270.
41. Cerf-Bensussan N, Jarry A, Brousse N, Lisowska-Grospierre B, Guy-Grand D, Griscelli C. A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes. Eur J Immunol 1987; 17:1279-1285.
42. Pauls K, Schon M, Kubitza RC, Homey B, Wiesenborn A, Lehmann P, et al. Role of integrin alphaE(CD103)beta7 for tissue-specific epidermal localization of CD8+ T lymphocytes. J Invest Dermatol 2001; 117:569-575.
43. von Roon AC, Reese G, Teare J, Constantinides V, Darzi AW, Tekkis PP. The risk of cancer in patients with Crohn's disease. Dis Colon Rectum 2007; 50:839-55