α-SMA overexpression associated with increased liver fibrosis in infants with biliary atresia

Journal of Pediatric Gastroenterology and Nutrition

Volumn 55, Issue 6, 2012, Pages 653-656

  Dong, Rui ^a   Luo, Yi ^a   Zheng, Shan ^a  

^a CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Biliary atresia; Liver fibrosis; Smooth muscle actin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BILIRUBIN; CD68 ANTIGEN; COLLAGEN; COLLAGEN FIBER;

ARTICLE; BILE DUCT ATRESIA; BILIRUBIN BLOOD LEVEL; CHOLANGIOGRAPHY; CHOLEDOCHOJEJUNOSTOMY; CHOLESTASIS; CLINICAL ARTICLE; COMMON BILE DUCT CYST; CORRELATION ANALYSIS; DISEASE ASSOCIATION; EPITHELIUM CELL; FEMALE; FIBROBLAST; FOLLOW UP; HUMAN; IMMUNOHISTOCHEMISTRY; INFANT; LAPAROTOMY; LIVER BIOPSY; LIVER FIBROSIS; LIVER HILUS; MALE; PORTOENTEROSTOMY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SCORING SYSTEM;

ACTINS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BILIARY ATRESIA; BILIRUBIN; COLLAGEN; EPITHELIAL CELLS; HUMANS; INFANT; LIVER; LIVER CIRRHOSIS; MUSCLE, SMOOTH; SEVERITY OF ILLNESS INDEX;

EID: 84870901051     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0b013e3182680be3     Document Type: Article

References (22)

1. Hartley J, Harnden A, Kelly D. Biliary atresia. BMJ 2010;340:c2383.
2. Santos JL, Choquette M, Bezerra JA. Cholestatic liver disease in children. Curr Gastroenterol Rep 2010;12:30-9.
3. Shen C, Zheng S, Wang W, et al. Relationship between prognosis of biliary atresia and infection of cytomegalovirus. World J Pediatr 2008;4:123-6.
4. Chang HK, Park YJ, Koh H, et al. Hepatic fibrosis scan for liver stiffness score measurement: a useful preendoscopic screening test for the detection of varices in postoperative patients with biliary atresia. J Pediatr Gastroenterol Nutr 2009;49:323-8.
5. Ramm GA, Nair VG, Bridle KR, et al. Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia. Am J Pathol 1998;153:527-35.
6. Huang CC, Chuang JH, Huang LL, et al. The human Delta-like 1 homologue is implicated in the progression of liver fibrosis in biliary atresia. J Pathol 2004;202:172-9.
7. Friedman SL. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 1993;328:1828-35.
8. Shteyer E, Ramm GA, Xu C, et al. Outcome after portoenterostomy in biliary atresia: pivotal role of degree of liver fibrosis and intensity of stellate cell activation. J Pediatr Gastroenterol Nutr 2006;42:93-9.
9. Weerasooriya VS, White FV, Shepherd RW. Hepatic fibrosis and survival in biliary atresia. J Pediatr 2004;144:123-5.
10. Mack CL, Tucker RM, Sokol RJ, et al. Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation. Pediatr Res 2004;56:79-87.
11. Mohanty SK, Ivantes CA, Mourya R, et al. Macrophages are targeted by rotavirus in experimental biliary atresia and induce neutrophil chemotaxis by Mip2/Cxcl2. Pediatr Res 2010;67:345-51.
12. Roggin KK, Kim JC, Kurkchubasche AG, et al. Macrophage phenotype during cholestatic injury and repair: the persistent inflammatory response. J Pediatr Surg 2001;36:220-8.
13. Kobayashi H, Horikoshi K, Long L, et al. Serum concentration of adhesion molecules in postoperative biliary atresia patients: relationship to disease activity and cirrhosis. J Pediatr Surg 2001;36:1297-301.
14. Ghoneim EM, Sira MM, Abd EA, et al. Diagnostic value of hepatic intercellular adhesion molecule-1 expression in Egyptian infants with biliary atresia and other forms of neonatal cholestasis. Hepatol Res 2011;41:763-75.
15. Van Obberghen-Schilling E, Roche NS, Flanders KC, et al. Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells. J Biol Chem 1988;263:7741-6.
16. Hinz B, Phan SH, Thannickal VJ, et al. The myofibroblast: one function, multiple origins. Am J Pathol 2007;170:1807-16.
17. Li Z, Dranoff JA, Chan EP, et al. Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture. Hepatology 2007;46:1246-56.
18. Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000;275:2247-50.
19. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005;115:209-18.
20. Farrington C, Novak D, Liu C, et al. Immunohistochemical localization of transforming growth factor beta-1 and its relationship with collagen expression in advanced liver fibrosis due to biliary atresia. Clin Exp Gastroenterol 2010;3:185-91.
21. Carpino G, Franchitto A, Morini S, et al. Activated hepatic stellate cells in liver cirrhosis. A morphologic and morphometrical study. Ital J Anat Embryol 2004;109:225-38.
22. Carpino G, Morini S, Ginanni CS, et al. Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation. Dig Liver Dis 2005;37:349-56.