High expression of neutrophil elastase predicts improved survival in pediatric acute myeloid leukemia: A report from the Children's Oncology Group

Leukemia and Lymphoma

Volumn 54, Issue 1, 2013, Pages 202-204

  Gudgeon, Chelsea J ^a   Harrington, Kimberly H ^a   Laszlo, George S ^a   Alonzo, Todd A ^b,c   Gerbing, Robert B ^c   Gamis, Alan S ^c,d   Raimondi, Susana C ^c,e   Hirsch, Betsy A ^c,f   Meshinchi, Soheil ^a,c,g   Walter, Roland B ^a,h  

^a USA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CHILDREN S ONCOLOGY GROUP   (United States)

^d CHILDREN S MERCY HOSPITAL   (United States)

^e ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^f UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINASE; BUSULFAN; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; GEMTUZUMAB OZOGAMICIN; LEUKOCYTE ELASTASE; MITOXANTRONE;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; CANCER SURVIVAL; CHILD; CHILDHOOD LEUKEMIA; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; DRUG SAFETY; FEMALE; HUMAN; INFANT; LETTER; LEUKEMIA REMISSION; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SCHOOL CHILD;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; GENE EXPRESSION; HUMANS; INFANT; LEUKEMIA, MYELOID, ACUTE; LEUKOCYTE ELASTASE; MALE; PROGNOSIS; YOUNG ADULT;

EID: 84870900807     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2012.700480     Document Type: Letter

References (15)

1. P ham CT. Neutrophil serine proteases: specifi c regulators of infl ammation. Nat Rev Immunol 2006;6:541-550. (Pubitemid 43980526)
2. K orkmaz B, Moreau T, Gauthier F. Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions. Biochimie 2008;90:227-242. (Pubitemid 351187763)
3. Havemann K, Gramse M, Gassel WD. Cytochemical determination of granulocyte elastase and chymotrypsin in human myeloid cells and its application in acquired defi ciency states and diagnosis of myeloid leukemia. Klin Wochenschr 1983;61:49-56. (Pubitemid 13177622)
4. K ramps JA, van der Valk P, van der Sandt MM, et al. Elastase as a marker for neutrophilic myeloid cells. J Histochem Cytochem 1984;32:389-394. (Pubitemid 14139591)
5. Davey FR, Erber WN, Gatter KC, et al. Immunophenotyping of acute myeloid leukemia by immuno-alkaline phosphatase (APAAP) labeling with a panel of antibodies. Am J Hematol 1987;26:157-166. (Pubitemid 17159690)
6. Pulford KA, Erber WN, Crick JA, et al. Use of monoclonal antibody against human neutrophil elastase in normal and leukaemic myeloid cells. J Clin Pathol 1988;41:853-860.
7. Hastka J. The importance of granulocyte elastase in haematological diagnosis. Blut 1988;57:69- 75.
8. Hiller E, Jochum M. Plasma levels of human granulocytic elastase alpha 1-proteinase inhibitor complex (E-alpha 1-PI) in leukemia. Blut 1984;48:269- 275. (Pubitemid 14104891)
9. Saito M, Asakura H, Uotani C,et al. Quantitative estimation of elastase-alpha 1-proteinase inhibitor (E-alpha 1 PI) complex in leukemia: Marked elevation in cases of acute promyelocytic leukemia. Th romb Res 1989;53:163- 171. (Pubitemid 19044644)
10. Lane AA, Ley TJ. Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice. Cell 2003;115:305-318. (Pubitemid 37487704)
11. Yong AS, Szydlo RM, Goldman JM, et al. Molecular profi ling of CD34 cells identifi es low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML. Blood 2006;107:205-212. (Pubitemid 43053545)
12. Yong AS, Rezvani K, Savani BN, et al. High PR3 or ELA2 expression by CD34 cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide-driven graftversus-leukemia eff ects. Blood 2007;110:770-775. (Pubitemid 47105416)
13. C ooper TM, Franklin J, Gerbing RB,et al. AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia: A report from the Children's Oncology Group. Cancer 2012;118:761-769.
14. K ern D, Collins M, Fultz T,et al. An enhanced-sensitivity branched-DNA assay for quantifi cation of human immunodefi ciency virus type 1 RNA in plasma. J Clin Microbiol 1996;34:3196-3202. (Pubitemid 26389381)
15. Flagella M, Bui S, Zheng Z,et al. A multiplex branched DNA assay for parallel quantitative gene expression profi ling. Anal Biochem 2006;352:50-60.