메뉴 건너뛰기




Volumn 108, Issue 6, 2012, Pages 1031-1036

Why does ticagrelor induce dyspnea?

Author keywords

ADP receptors; Arterial thrombosis; Nervous system

Indexed keywords

ADENOSINE; CANGRELOR; CLOPIDOGREL; DIPYRIDAMOLE; ELINOGREL; PURINERGIC P2Y12 RECEPTOR; THIENOPYRIDINE DERIVATIVE; TICAGRELOR;

EID: 84870897766     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-08-0547     Document Type: Article
Times cited : (87)

References (35)
  • 1
    • 79951848755 scopus 로고    scopus 로고
    • The platelet P2Y12 receptor for adenosine diphosphate: Congenital and drug-induced defects
    • Cattaneo M. The platelet P2Y12 receptor for adenosine diphosphate: congenital and drug-induced defects. Blood 2011; 117: 2102-2112.
    • (2011) Blood , vol.117 , pp. 2102-2112
    • Cattaneo, M.1
  • 2
    • 74549137908 scopus 로고    scopus 로고
    • New P2Y12 Inhibitors
    • Cattaneo M. New P2Y12 Inhibitors. Circulation 2010; 121: 171-179.
    • (2010) Circulation , vol.121 , pp. 171-179
    • Cattaneo, M.1
  • 3
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009; 361: 1045-1057.
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3    et al4
  • 4
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacoki-netics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted S, Emanuelsson H, Heptinstall S, et al. Pharmacodynamics, pharmacoki-netics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. Eur Heart J 2006; 27: 1038-1047.
    • (2006) Eur Heart J , vol.27 , pp. 1038-1047
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3    et al4
  • 5
    • 35548995394 scopus 로고    scopus 로고
    • Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: Primary results of the DISPERSE-2 trial
    • Cannon C P, Husted S, Harrington RA, et al. Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: primary results of the DISPERSE-2 trial. J Am Coll Cardiol 2007; 50: 1844-1851.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1844-1851
    • Cannon, C.P.1    Husted, S.2    Harrington, R.A.3    et al4
  • 6
    • 73949112820 scopus 로고    scopus 로고
    • Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: The ONSET/OFFSET study
    • Gurbel PA, Bliden K P, Butler K et al. Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study. Circulation 2009; 120: 2577-2585.
    • (2009) Circulation , vol.120 , pp. 2577-2585
    • Gurbel, P.A.1    Bliden, K.P.2    Butler, K.3    et al4
  • 7
    • 77955110385 scopus 로고    scopus 로고
    • Incidence of dyspnea and assessment of cardiac and pulmonary function in patients with stable coronary artery disease receiving ticagrelor, clopidogrel, or placebo in the ONSET/OFFSET study
    • Storey RF, Bliden K P, Patil SB, et al. Incidence of dyspnea and assessment of cardiac and pulmonary function in patients with stable coronary artery disease receiving ticagrelor, clopidogrel, or placebo in the ONSET/OFFSET study. J Am Coll Cardiol 2010; 56: 185-193.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 185-193
    • Storey, R.F.1    Bliden, K.P.2    Patil, S.B.3    et al4
  • 8
    • 77950508416 scopus 로고    scopus 로고
    • Response to ticagrelor in clopidogrel nonre-sponders and responders and effect of switching therapies: The RESPOND study
    • Gurbel PA, Bliden K P, Butler K, et al. Response to ticagrelor in clopidogrel nonre-sponders and responders and effect of switching therapies: the RESPOND study. Circulation 2010; 121: 1188-1199.
    • (2010) Circulation , vol.121 , pp. 1188-1199
    • Gurbel, P.A.1    Bliden, K.P.2    Butler, K.3    et al4
  • 9
    • 82955201646 scopus 로고    scopus 로고
    • Characterization of dyspnoea in PLATO study patients treated with ticagrelor or clopidogrel and its association with clinical outcomes
    • Storey RF, Becker RC, Harrington RA, et al. Characterization of dyspnoea in PLATO study patients treated with ticagrelor or clopidogrel and its association with clinical outcomes. Eur Heart J 2011; 32: 2945-2953.
    • (2011) Eur Heart J , vol.32 , pp. 2945-2953
    • Storey, R.F.1    Becker, R.C.2    Harrington, R.A.3    et al4
  • 10
    • 71849087338 scopus 로고    scopus 로고
    • Platelet inhibition with cangrelor in patients undergoing PCI
    • Harrington RA, Stone GW, McNulty S, et al. Platelet inhibition with cangrelor in patients undergoing PCI. N Engl J Med 2009; 361: 2318-2329.
    • (2009) N Engl J Med , vol.361 , pp. 2318-2329
    • Harrington, R.A.1    Stone, G.W.2    McNulty, S.3    et al4
  • 11
    • 84864617340 scopus 로고    scopus 로고
    • A Randomized, Double-Blind, Active-Controlled Phase 2 Trial to Evaluate a Novel Selective and Reversible Intravenous and Oral P2Y12 Inhibitor Elinogrel Versus Clopidogrel in Patients Undergoing Nonurgent Percutaneous Coronary Intervention: The INNOVATE-PCI Trial
    • Welsh RC, Rao S V, Zeymer U, et al. A Randomized, Double-Blind, Active-Controlled Phase 2 Trial to Evaluate a Novel Selective and Reversible Intravenous and Oral P2Y12 Inhibitor Elinogrel Versus Clopidogrel in Patients Undergoing Nonurgent Percutaneous Coronary Intervention: The INNOVATE-PCI Trial. Circ Cardiovasc Interv 2012;5: 336-346.
    • (2012) Circ Cardiovasc Interv , vol.5 , pp. 336-346
    • Welsh, R.C.1    Rao, S.V.2    Zeymer, U.3    et al4
  • 12
    • 71849119604 scopus 로고    scopus 로고
    • Intravenous platelet blockade with can-grelor during PCI
    • Bhatt DL, Lincoff AM, Gibson CM, et al. Intravenous platelet blockade with can-grelor during PCI. N Engl J Med 2009; 361: 2330-2341.
    • (2009) N Engl J Med , vol.361 , pp. 2330-2341
    • Bhatt, D.L.1    Lincoff, A.M.2    Gibson, C.M.3    et al4
  • 13
    • 84856023997 scopus 로고    scopus 로고
    • Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: A randomized controlled trial
    • Angiolillo DJ, Firstenberg MS, Price MJ, et al. Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: a randomized controlled trial. J Am Med Assoc 2012; 307: 265-274.
    • (2012) J Am Med Assoc , vol.307 , pp. 265-274
    • Angiolillo, D.J.1    Firstenberg, M.S.2    Price, M.J.3    et al4
  • 14
    • 48949093184 scopus 로고    scopus 로고
    • Incidence and causes of new-onset dyspnea in 3,719 patients treated with clopidogrel and aspirin combination after coronary stenting
    • Serebruany V, Pokov I, Kuliczkowski W,et al. Incidence and causes of new-onset dyspnea in 3,719 patients treated with clopidogrel and aspirin combination after coronary stenting. Thromb Haemost 2008; 100: 314-318.
    • (2008) Thromb Haemost , vol.100 , pp. 314-318
    • Serebruany, V.1    Pokov, I.2    Kuliczkowski, W.3
  • 15
    • 80955144190 scopus 로고    scopus 로고
    • Pulmonary function in patients with acute coronary syndrome treated with ticagrelor or clopidogrel (from the Platelet Inhibition and Patients Outcomes (PLATO) pulmonary function substudy)
    • Storey RF, Becker RC, Harrington RA, et al. Pulmonary function in patients with acute coronary syndrome treated with ticagrelor or clopidogrel (from the Platelet Inhibition and Patients Outcomes (PLATO) pulmonary function substudy). Am J Cardiol 2011; 108: 1542-1546.
    • (2011) Am J Cardiol , vol.108 , pp. 1542-1546
    • Storey, R.F.1    Becker, R.C.2    Harrington, R.A.3    et al4
  • 16
    • 78349249073 scopus 로고    scopus 로고
    • Mechanisms of dyspnea
    • Burki NK, Lee L-Y. Mechanisms of dyspnea. Chest 2010; 138: 1196-1201.
    • (2010) Chest , vol.138 , pp. 1196-1201
    • Burki, N.K.1    Lee, L.Y.2
  • 17
    • 84866479608 scopus 로고    scopus 로고
    • Ticagrelor inhibits adenosine uptake in vitro and enhances adenosine-mediated hypermeia responses in a canine model
    • Van Giezen JJ, Sidaway J, Glaves P, et al. Ticagrelor inhibits adenosine uptake in vitro and enhances adenosine-mediated hypermeia responses in a canine model. J Cardiovasc Pharmacol Ther 2012; 17: 164-172.
    • (2012) J Cardiovasc Pharmacol Ther , vol.17 , pp. 164-172
    • van Giezen, J.J.1    Sidaway, J.2    Glaves, P.3    et al4
  • 18
    • 0025341964 scopus 로고
    • The safety of intravenous dipyridamole thallium myocardial perfusion imaging. Intravenous Dipyridamole Thallium Imaging Study Group
    • Ranhosky A, Kempthorne-Rawson J. The safety of intravenous dipyridamole thallium myocardial perfusion imaging. Intravenous Dipyridamole Thallium Imaging Study Group. Circulation 1990; 81: 1205-1209.
    • (1990) Circulation , vol.81 , pp. 1205-1209
    • Ranhosky, A.1    Kempthorne, R.J.2
  • 19
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • TRITON-TIMI 38 Investigators
    • Wiviott SD, Braunwald E, McCabe CH, et al; TRITON-TIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007; 357: 2001-2015.
    • (2007) N Engl J Med , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3    et al4
  • 20
    • 84870943310 scopus 로고    scopus 로고
    • Food and Drug Administration (FDA, Available at, Accessed: June 18
    • Food and Drug Administration (FDA). Effient (prasugrel) tablets label. Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022307s003lbl.pdf, page 6. Accessed: June 18, 2012.
    • (2012) Effient (prasugrel) Tablets Label , pp. 6
  • 21
    • 0036176606 scopus 로고    scopus 로고
    • Inhibition of adenylyl cyclase by neuronal P2Y receptors
    • Unterberger U, Moskvina E, Scholze T, et al. Inhibition of adenylyl cyclase by neuronal P2Y receptors. Br J Pharmacol 2002; 135: 673-684.
    • (2002) Br J Pharmacol , vol.135 , pp. 673-684
    • Unterberger, U.1    Moskvina, E.2    Scholze, T.3    et al4
  • 22
    • 77950838144 scopus 로고    scopus 로고
    • Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior
    • Malin SA, Molliver DC. Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior. Mol Pain 2010; 6: 21-25.
    • (2010) Mol Pain , vol.6 , pp. 21-25
    • Malin, S.A.1    Molliver, D.C.2
  • 23
    • 0037275786 scopus 로고    scopus 로고
    • Attenuation of the P2Y receptor-mediated control of neuronal Ca2+ channels in PC12 cells by antithrombotic drugs
    • Kubista H, Lechner SG, Wolf AM, et al. Attenuation of the P2Y receptor-mediated control of neuronal Ca2+ channels in PC12 cells by antithrombotic drugs. Br J Pharmacol 2003; 138: 343-350.
    • (2003) Br J Pharmacol , vol.138 , pp. 343-350
    • Kubista, H.1    Lechner, S.G.2    Wolf, A.M.3    et al4
  • 24
    • 33947214587 scopus 로고    scopus 로고
    • Prostaglandin E2 enhances the sensitizing effect of hyperthermia on pulmonary C-fibers in rats
    • Zhang G, Lee LY. Prostaglandin E2 enhances the sensitizing effect of hyperthermia on pulmonary C-fibers in rats. Respir Physiol Neurobiol 2007; 156: 241-249.
    • (2007) Respir Physiol Neurobiol , vol.156 , pp. 241-249
    • Zhang, G.1    Lee, L.Y.2
  • 25
    • 0026875597 scopus 로고
    • Pro s ta gland in E2 inhalation increases the sensation of dyspnea during exercise
    • Taguchi O, Ki ku chi Y, Hida W, et al. Pro s ta gland in E2 inhalation increases the sensation of dyspnea during exercise. Am Rev Respir Dis 1992; 145: 1346-1349.
    • (1992) Am Rev Respir Dis , vol.145 , pp. 1346-1349
    • Taguchi, O.1    Ki, K.C.Y.2    Hida, W.3    et al4
  • 26
    • 34247566600 scopus 로고    scopus 로고
    • 12 receptor for adenosine dip-hosphate potentiates the antiplatelet effect of prostacyclin
    • Cattaneo M, Lecchi A. Inhibition of the platelet P2Y12 receptor for adenosine dip-hosphate potentiates the antiplatelet effect of prostacyclin. J Thromb Haemost 2007; 5: 577-582.
    • (2007) J Thromb Haemost , vol.5 , pp. 577-582
    • Cattaneo, M.1    Lecchi, A.2
  • 27
    • 84860463430 scopus 로고    scopus 로고
    • Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients with Stable Coronary Artery Disease: Results from the ONSET-OFFSET and RESPOND Studies
    • Husted SE, Storey RF, Bliden K, et al. Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients with Stable Coronary Artery Disease: Results from the ONSET-OFFSET and RESPOND Studies. Clin Pharmacokinet 2012; 51: 397-409.
    • (2012) Clin Pharmacokinet , vol.51 , pp. 397-409
    • Husted, S.E.1    Storey, R.F.2    Bliden, K.3    et al4
  • 28
    • 79960999130 scopus 로고    scopus 로고
    • Pharmacology and clinical trials of reversibly-binding P2Y12 inhibitors
    • Storey RF. Pharmacology and clinical trials of reversibly-binding P2Y12 inhibitors. Thromb Haemost 2011; 105 (Suppl 1): S75-81.
    • (2011) Thromb Haemost , vol.105 , Issue.SUPPL. 1
    • Storey, R.F.1
  • 29
    • 84864620660 scopus 로고    scopus 로고
    • Pharmacokinetic and Pharmacodynamic Effects of Elinogrel: Results of the Platelet Function Substudy From the Intra-venous and Oral Administration of Elinogrel to Evaluate Tolerability and Efficacy in Nonurgent Percutaneous Coronary Intervention Patients (INNOVATE-PCI) Trial
    • Angiolillo DJ, Welsh RC, Trenk D, et al. Pharmacokinetic and Pharmacodynamic Effects of Elinogrel: Results of the Platelet Function Substudy From the Intra-venous and Oral Administration of Elinogrel to Evaluate Tolerability and Efficacy in Nonurgent Percutaneous Coronary Intervention Patients (INNOVATE-PCI) Trial. Circ Cardiovasc Interv 2012; 5: 347-356.
    • (2012) Circ Cardiovasc Interv , vol.5 , pp. 347-356
    • Angiolillo, D.J.1    Welsh, R.C.2    Trenk, D.3    et al4
  • 30
    • 36348977461 scopus 로고    scopus 로고
    • Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel
    • Payne CD, Li YG, Small DS, et al. Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel. J Cardiovasc Pharmacol 2007; 50: 555-562.
    • (2007) J Cardiovasc Pharmacol , vol.50 , pp. 555-562
    • Payne, C.D.1    Li, Y.G.2    Small, D.S.3    et al4
  • 31
    • 77954095160 scopus 로고    scopus 로고
    • In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons
    • Dieterich DC, Hodas JJ, Gouzer G, et al. In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons. Nat Neurosci 2010; 13: 897-905.
    • (2010) Nat Neurosci , vol.13 , pp. 897-905
    • Dieterich, D.C.1    Hodas, J.J.2    Gouzer, G.3    et al4
  • 33
    • 33847050871 scopus 로고    scopus 로고
    • Dyspnoea after antiplatelet agents: The AZD6140 controversy
    • Serebruany VL, Stebbing J, Atar D. Dyspnoea after antiplatelet agents: the AZD6140 controversy. Int J Clin Pract 2007; 61: 529-533.
    • (2007) Int J Clin Pract , vol.61 , pp. 529-533
    • Serebruany, V.L.1    Stebbing, J.2    Atar, D.3
  • 34
    • 0041377009 scopus 로고    scopus 로고
    • Interoception: The sense of the physiological condition of the body
    • Craig AD. Interoception: the sense of the physiological condition of the body. Curr Opin Neurobiol 2003; 13: 500-5.
    • (2003) Curr Opin Neurobiol , vol.13 , pp. 500-505
    • Craig, A.D.1
  • 35
    • 36849074168 scopus 로고    scopus 로고
    • Prasugrel: A novel thienopyridine antiplatelet agent. A review of preclinical and clinical studies and the mechanistic basis for its distinct antiplatelet profile
    • Jakubowski JA, Winters KJ, Naganuma H, et al. Prasugrel: a novel thienopyridine antiplatelet agent. A review of preclinical and clinical studies and the mechanistic basis for its distinct antiplatelet profile. Cardiovasc Drug Rev 2007; 25: 357-374.
    • (2007) Cardiovasc Drug Rev , vol.25 , pp. 357-374
    • Jakubowski, J.A.1    Winters, K.J.2    Naganuma, H.3    et al4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.