Hong Kong experiences the 'ultimate superbug': NDM-1 Enterobacteriaceae

Hong Kong Medical Journal

Volumn 18, Issue 5, 2012, Pages 439-441

  Tsang, K Y ^a   Luk, S ^b   Lo, Janice Y C ^c   Tsang, T Y ^a   Lai, S T ^a   Ng, T K ^b  

^a PRINCESS MARGARET HOSPITAL   (Hong Kong)

^b Department of Microbiology ^*  (Hong Kong)

^c DEPARTMENT OF HEALTH   (Hong Kong)

Author keywords

Anti bacterial agents; Beta Lactamases; Drug resistance, multiple, bacterial; Enterobacteriaceae infections; Hong Kong

Indexed keywords

CARBAPENEM; ERTAPENEM; IMIPENEM; MEROPENEM;

ACINETOBACTER; ADULT; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; CASE REPORT; DYSPNEA; ENTEROBACTERIACEAE INFECTION; ESCHERICHIA COLI; FEMALE; FEVER; HEALTH HAZARD; HIGH RISK PATIENT; HONG KONG; HUMAN; INDIAN; INTENSIVE CARE UNIT; MEDICAL CARE; NEW DELHI METALLO-BETA-LACTAMASE ENTEROBACTERIACEAE INFECTION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; POSTOPERATIVE INFECTION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; PUBLIC HEALTH; RISK FACTOR; SUBDURAL HEMATOMA;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; DRUG RESISTANCE, BACTERIAL; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; FEMALE; HONG KONG; HUMANS; MIDDLE AGED; TRAVEL;

EID: 84870886858     PISSN: 10242708     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Laboratory protocol for detection of Carbapenem-resistant or Carbapenemase-producing, Klebsiella spp. and E. coli from rectal swabs. US Centers for Disease Control and Prevention website: http://www.cdc.gov/HAI/settings/lab/lab_settings.html. Accessed 14 Mar 2012.
2. Clinical Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing, 20th information supplement, document M100-S20. Wayne, PA: CLSI; 2010.
3. Tsakris A, Poulou A, Pournaras S, et al. A simple phenotypic method for the differentiation of metallo-beta-lactamases and class A KPC carbapenemases in Enterobacteriaceae clinical isolates. J Antimicrob Chemother 2010;65:1664-71.
4. Miriagou V, Cornaglia G, Edelstein M, et al. Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues. Clin Microbiol Infect 2010;16:112-22.
5. Lee K, Yum JH, Yong D, et al. Novel acquired metallo-beta-lactamase gene, bla(SIM-1), in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea. Antimicrob Agents Chemother 2005;49:4485-91.
6. Cornaglia G, Akova M, Amicosante G, et al. Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues. Int J Antimicrob Agents 2007;29:380-8.
7. Walsh TR. Clinically significant carbapenemases: an update. Curr Opin Infect Dis 2008;21:367-71.
8. Yong D, Toleman MA, Giske CG, et al. Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother 2009;53:5046-54.
9. New Delhi metallo-β-lactamase 1 Enterobacteriaceae. Centres for Disease Control, R.O.C. (Taiwan) website: http://www.cdc.gov.tw/uploads/files/201206/db0c45c1-85e6-445e-b2c7-6d1201f0f033.pdf. Accessed 30 Jun 2012.
10. Struelens M J, Monnet DL, Magiorakos AP, Santos O'Connor F, Giesecke J; European NDM-1 Survey Participants. New Delhi metallo-beta-lactamase 1-producing Enterobacteriaceae: emergence and response in Europe. Euro Surveill 2010;15:pii:19716.
11. Chu YW, Tung VW, Cheung TK, et al. Carbapenemases in enterobacteria, Hong Kong, China, 2009. Emerg Infect Dis 2011;17:130-2.
12. Kumarasamy KK, Toleman MA, Walsh TR, et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 2010;10:597-602.
13. Walsh TR, Weeks J, Livermore DM, Toleman MA. Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. Lancet Infect Dis 2011;11:355-62.
14. Karthikeyan K, Thirunarayan MA, Krishnan P. Coexistence of blaOXA-23 with blaNDM-1 and armA in clinical isolates of Acinetobacter baumannii from India. J Antimicrob Chemother 2010;65:2253-70.
15. Chen Y, Zhou Z, Jiang Y, Yu Y. Emergence of NDM-1-producing Acinetobacter baumannii in China. J Antimicrob Chemother 2011;66:1255-9.
16. Kaase M, Nordmann P, Wichelhaus TA, Gatermann SG, Bonnin RA, Poirel L. NDM-2 carbapenemase in Acinetobacter baumannii from Egypt. J Antimicrob Chemother 2011;66:1260-2.