Recent combined hormonal contraceptives (CHCs) and the risk of thromboembolism and other cardiovascular events in new users

Contraception

Volumn 87, Issue 1, 2013, Pages 93-100

  Sidney, Stephen ^a   Cheetham, T Craig ^b   Connell, Frederick A ^c   Ouellet Hellstrom, Rita ^d   Graham, David J ^d   Davis, Daniel ^d   Sorel, Michael ^a   Quesenberry Jr , Charles P ^a   Cooper, William O ^e  

^a DIVISION OF RESEARCH   (United States)

^b Pharmacy Analytic Services   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e VANDERBILT UNIVERSITY   (United States)

Author keywords

Cardiovascular disease; Contraceptives; Epidemiology; Venous thromboembolism

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DROSPIRENONE; ESTROGEN; ETONOGESTREL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; NORELGESTROMIN;

ADOLESCENT; ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHILD; FEMALE; HEALTH PROGRAM; HORMONAL CONTRACEPTION; HUMAN; INTEGRATED HEALTH CARE SYSTEM; MAJOR CLINICAL STUDY; MEDICAID; THROMBOEMBOLISM;

ADOLESCENT; ADULT; ANDROSTENES; ARTERIES; CALIFORNIA; CHILD; CONTRACEPTIVE AGENTS, FEMALE; DESOGESTREL; DRUG COMBINATIONS; ESTROGENS; ETHINYL ESTRADIOL; FEMALE; HOSPITALIZATION; HUMANS; INCIDENCE; MIDDLE AGED; MYOCARDIAL INFARCTION; NORGESTREL; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; STROKE; TENNESSEE; THROMBOEMBOLISM; TIME FACTORS; VENOUS THROMBOEMBOLISM; WASHINGTON; YOUNG ADULT;

EID: 84870868340     PISSN: 00107824     EISSN: 18790518     Source Type: Journal    
DOI: 10.1016/j.contraception.2012.09.015     Document Type: Article

References (21)

1. Cardiovascular disease and steroid hormone contraception. Technical report series: WHO 1998.
2. W.S. Chan, J. Ray, E.K. Wai, S. Ginsburg, M.E. Hannah, P.N. Corey, and J.S. Ginsberg Risk of stroke in women exposed to low-dose oral contraceptives: a critical evaluation of the evidence Arch Intern Med 164 2004 741 747
3. J.P. Baillargeon, D.K. McClish, P.A. Essah, and J.E. Nestler Association between the current use of low-dose oral contraceptives and cardiovascular arterial disease: a meta-analysis J Clin Endocrinol Metab 90 2005 3863 3870 [Epub 2005 Apr 6]
4. J.C. Dinger, L.A. Heinemann, and D. Kühl-Habich The safety of a drospirenone-containing oral contraceptive: final results from the European Active Surveillance Study on oral contraceptives based on 142,475 women-years of observation Contraception 75 2007 344 354 [Epub 2007 Feb 23]
5. J. Dinger, A. Assmann, S. Möhner, and T.D. Minh Risk of venous thromboembolism and the use of dienogest- and drospirenone-containing oral contraceptives: results from a German case-control study J Fam Plan Repro Health Care. 36 2010 123 129
6. J.D. Seeger, J. Loughlin, P.M. Eng, C.R. Clifford, J. Cutone, and A.M. Walker Risk of thromboembolism in women taking ethinylestradiol/drospirenone and other oral contraceptives Obstet Gynecol 110 2007 587 593
7. A. van Hylckama Vlieg, F.M. Helmerhorst, J.P. Vandenbroucke, C.J. Doggen, and F.R. Rosendaal The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study BMJ 339 2009 b2921 10.1136/bmj.b2921
8. V. Lidegaard, E. Lokkegaard, A.L. Svendsen, and C. Agger Hormonal contraception and risk of venous thromboembolism: national follow-up study BMJ 339 2009 2890 10.1136/bmj.b28
9. L. Parkin, K. Sharples, R.K. Hernandez, and S.S. Jick Risk of venous thromboembolism in users of oral contraceptives containing drospirenone or levonorgestrel: nested case-control study based on UK General Practice Research Database BMJ 342 2011 d2139 10.1136/bmj.d2139
10. S.S. Jick, and R.K. Hernandez Risk of non-fatal venous thromboembolism in women using oral contraceptives containing drospirenone compared with women using oral contraceptives containing levonorgestrel: case-control study using United States claims data BMJ 342 2011 Apr 21 d2151 10.1136/bmj.d2151
11. O. Lidegaard, L.H. Nielsen, C.W. Skovlund, F.E. Skjeldestad, and E. Lokkegaard Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9 BMJ 343 2011 d6423 10.1136/bmj.d6423
12. N. Gronich, I. Lavi, and G. Rennert Higher risk of venous thrombosis associated with drospirenone-containing oral contraceptives: a population-based study CMAJ. 183 2011 E1319 E1325
13. S.S. Jick, J.A. Kaye, S. Russmann, and H. Jick Risk of non-fatal venous thromboembolism in women using a contraceptive transdermal patch and oral contraceptives containing norgestimate and 35 μg if ethinyl estradiol Contraception 73 2006 223 228
14. S. Jick, J.A. Kaye, L. Li, and H. Jick Further results on the risk of nonfatal venous thromboembolism in users of the contraceptive transdermal patch compared to users of oral contraceptives containing norgestimate and 35 micrograms of ethinyl estradiol Contraception 76 2007 4 7 [Epub 2007 May 11]
15. S.S. Jick, K.W. Hagberg, and J.A. Kaye ORTHO EVRA and venous thromboembolism: an update Contraception 81 2010 452 453 [Epub 2010 Jan 27. No abstract available.]
16. S.S. Jick, K.W. Hagberg, R.K. Hernandez, and J.A. Kaye Postmarketing study of ORTHO EVRA and levonorgestrel oral contraceptives containing hormonal contraceptives with 30 mcg of ethinyl estradiol in relation to nonfatal venous thromboembolism Contraception 81 2010 16 21 [Epub]
17. J.A. Cole, H. Norman, M. Doherty, and A.M. Walker Venous thromboembolism, myocardial infarction, and stroke among transdermal contraceptive system users Obstet Gynecol 109 2007 339 346
18. D.D. Dore, H. Norman, J. Loughlin, and J.D. Seeger Extended case-control study results on thromboembolic outcomes among transdermal contraceptive users Contraception 81 2010 408 413 [Epub 2010 Jan 22]
19. O. Lidegaard, L.H. Nielsen, C.W. Skovlund, and E. Lokkegaard Venous thrombosis in users of non-oral hormonal contraception: follow-up study, Denmark 2001-10 BMJ 344 2012 e2990 e2998
20. S.S. Jick, and H. Jick The contraceptive patch in relation to ischemic stroke and acute myocardial infarction Pharmacotherapy 27 2 2007 218 220
21. W.A. Ray Evaluating medication effects outside of clinical trials: new-user designs Am J Epidemiol 158 2003 915 920