Molecular signature of the immune and tissue response to non-coding plasmid DNA in skeletal muscle after electrotransfer

Gene Therapy

Volumn 19, Issue 12, 2012, Pages 1177-1186

  Mann, C J ^a,b   Anguela, X M ^a,b   Montane J ^a,b   Obach, M ^a,b   Roca, C ^a,b   Ruzo, A ^a,b   Otaegui, P ^a,b   Mir, L M ^c   Bosch, F ^a,b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

electrotransfer; immune response; innate immunity; non viral gene delivery; plasmid DNA; skeletal muscle

Indexed keywords

EXTRACHROMOSOMAL DNA; INFLAMMASOME; NON CODING PLASLMID DNA; PLASMID DNA; SODIUM CHLORIDE; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CPG ISLAND; DNA DAMAGE; DNA REPAIR; ELECTROPORATION; FLUORESCENCE ACTIVATED CELL SORTER; GENE EXPRESSION; GENE EXPRESSION PROFILING; INFLAMMATORY INFILTRATE; INNATE IMMUNITY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PATTERN RECOGNITION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SKELETAL MUSCLE; TISSUE REACTION; UPREGULATION;

ANIMALS; ELECTROPORATION; GENETIC THERAPY; IMMUNITY, INNATE; MALE; MICE; MUSCLE, SKELETAL; PLASMIDS; TOLL-LIKE RECEPTOR 9; TRANSCRIPTOME;

EID: 84870846400     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.198     Document Type: Article

References (48)

1. Wolff JA, Budker V. The mechanism of naked DNA uptake and expression.Adv Genet 2005; 54: 3-20.
2. Mir LM. Nucleic acids electrotransfer-based gene therapy (electrogenetherapy):past, current, and future. Mol Biotechnol 2009; 43: 167-176.
3. Lu QL, Bou-Gharios G, Partridge TA. Non-viral gene delivery in skeletal muscle: aprotein factory. Gene Therapy 2003; 10: 131-142.
4. Braun S. Muscular gene transfer using nonviral vectors. Curr Gene Ther 2008;8: 391-405.
5. Babiuk S, van Drunen Littel-van den H, Babiuk LA. Delivery of DNA vaccines usingelectroporation. Methods Mol Med 2006; 127: 73-82.
6. Luckay A, Sidhu MK, Kjeken R, Megati S, Chong SY, Roopchand V et al. Effect ofplasmid DNA vaccine design and in vivo electroporation on the resulting vaccinespecificimmune responses in rhesus macaques. J Virol 2007; 81: 5257-5269.
7. Mingozzi F, High KA. Immune responses to AAV in clinical trials. Curr Gene Ther2007; 7: 316-324.
8. Marino M, Scuderi F, Provenzano C, Bartoccioni E. Skeletal muscle cells: from localinflammatory response to active immunity. Gene Therapy 2011; 18: 109-116.
9. Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu RevImmunol 2002; 20: 709-760.
10. Wagner H. The immunobiology of the TLR9 subfamily. Trends Immunol 2004;25: 381-386.
11. Meylan E, Tschopp J, Karin M. Intracellular pattern recognition receptors in thehost response. Nature 2006; 442: 39-44.
12. Hornung V, Latz E. Intracellular DNA recognition. Nat Rev Immunol 2010;10: 123-130.
13. Martinon F, Mayor A, Tschopp J. The inflammasomes: guardians of the body. AnnuRev Immunol 2009; 27: 229-265.
14. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity:update on Toll-like receptors. Nat Immunol 2011; 11: 373-384.
15. Boyle EI, Weng S, Gollub J, Jin H, Botstein D, Cherry JM et al. GO::TermFinder-opensource software for accessing Gene Ontology information and findingsignificantly enriched Gene Ontology terms associated with a list of genes.Bioinformatics 2004; 20: 3710-3715.
16. Nicolas N, Marazzi G, Kelley K, Sassoon D. Embryonic deregulation of muscle stresssignaling pathways leads to altered postnatal stem cell behavior and a failure inpostnatal muscle growth. Dev Biol 2005; 281: 171-183.
17. Krief S, Faivre JF, Robert P, Le Douarin B, Brument-Larignon N, Lefrere I et al.Identification and characterization of cvHsp. A novel human small stress proteinselectively expressed in cardiovascular and insulin-sensitive tissues. J Biol Chem1999; 274: 36592-36600.
18. Liu Y, Wang J, Yi Y, Zhang H, Liu J, Liu M et al. Induction of KLF4 in response toheat stress. Cell Stress Chaperones 2006; 11: 379-389.
19. Wiendl H, Hohlfeld R, Kieseier BC. Immunobiology of muscle: advances inunderstanding an immunological microenvironment. Trends Immunol 2005;26: 373-380.
20. Bekpen C, Hunn JP, Rohde C, Parvanova I, Guethlein L, Dunn DM et al. Theinterferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomousresistance mechanism in the human lineage. Genome Biol 2005; 6: R92.
21. Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T et al. DAI (DLM-1/ZBP1) is acytosolic DNA sensor and an activator of innate immune response. Nature 2007;448: 501-505.
22. Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H et al. HMGB proteinsfunction as universal sentinels for nucleic-acid-mediated innate immuneresponses. Nature 2009; 462: 99-103.
23. Kim T, Pazhoor S, Bao M, Zhang Z, Hanabuchi S, Facchinetti V et al. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sensemicrobial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci USA2010; 107: 15181-15186.
24. Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S et al. IFI16 isan innate immune sensor for intracellular DNA. Nat Immunol 2010; 11: 997-1004.
25. Stetson DB, Ko JS, Heidmann T, Medzhitov R. Trex1 prevents cell-intrinsicinitiation of autoimmunity. Cell 2008; 134: 587-598.
26. Chiu YH, Macmillan JB, Chen ZJ. RNA polymerase III detects cytosolic DNA andinduces type I interferons through the RIG-I pathway. Cell 2009; 138: 576-591.
27. Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V. RIG-Idependentsensing of poly(dA:dT) through the induction of an RNA polymeraseIII-transcribed RNA intermediate. Nat Immunol 2009; 10: 1065-1072.
28. Kim YM, Brinkmann MM, Paquet ME, Ploegh HL. UNC93B1 delivers nucleotidesensingtoll-like receptors to endolysosomes. Nature 2008; 452: 234-238.
29. Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T et al. TANK-bindingkinase-1 delineates innate and adaptive immune responses to DNA vaccines.Nature 2008; 451: 725-729.
30. Sadler AJ, Williams BR. Interferon-inducible antiviral effectors. Nat Rev Immunol2008; 8: 559-568.
31. Shirota H, Petrenko L, Hong C, Klinman DM. Potential of transfected muscle cellsto contribute to DNA vaccine immunogenicity. J Immunol 2007; 179: 329-336.
32. Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F et al. A Toll-like receptorindependentantiviral response induced by double-stranded B-form DNA. NatImmunol 2006; 7: 40-48.
33. Stetson DB, Medzhitov R. Recognition of cytosolic DNA activates anIRF3-dependent innate immune response. Immunity 2006; 24: 93-103.
34. Arnold L, Henry A, Poron F, Baba-Amer Y, van Rooijen N, Plonquet A et al.Inflammatory monocytes recruited after skeletal muscle injury switch intoantiinflammatory macrophages to support myogenesis. J Exp Med 2007;204: 1057-1069.
35. Orange JS, Ballas ZK. Natural killer cells in human health and disease. ClinImmunol 2006; 118: 1-10.
36. Tamura T, Yanai H, Savitsky D, Taniguchi T. The IRF family transcription factors inimmunity and oncogenesis. Annu Rev Immunol 2008; 26: 535-584.
37. Hojman P, Zibert JR, Gissel H, Eriksen J, Gehl J. Gene expression profiles in skeletalmuscle after gene electrotransfer. BMC Mol Biol 2007; 8: 56.
38. Rubenstrunk A, Mahfoudi A, Scherman D. Delivery of electric pulses for DNAelectrotransfer to mouse muscle does not induce the expression of stress relatedgenes. Cell Biol Toxicol 2004; 20: 25-31.
39. Hojman P, Gissel H, Andre F, Cournil-Henrionnet C, Eriksen J, Gehl J et al.Physiological effects of high and low voltage pulse combinations for geneelectrotransfer in muscle. Hum Gene Ther 2008; 19: 1249-1260.
40. Dupuis M, Denis-Mize K, Woo C, Goldbeck C, Selby MJ, Chen M et al. Distributionof DNA vaccines determines their immunogenicity after intramuscular injection inmice. J Immunol 2000; 165: 2850-2858.
41. Kutzler MA, Weiner DB. DNA vaccines: ready for prime time? Nat Rev Genet 2008;9: 776-788.
42. Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. Crucial role forthe Nalp3 inflammasome in the immunostimulatory properties of aluminiumadjuvants. Nature 2008; 453: 1122-1126.
43. McCaffrey AP, Fawcett P, Nakai H, McCaffrey RL, Ehrhardt A, Pham TT et al. Thehost response to adenovirus, helper-dependent adenovirus, and adenoassociatedvirus in mouse liver. Mol Ther 2008; 16: 931-941.
44. Hartman ZC, Black EP, Amalfitano A. Adenoviral infection induces a multi-facetedinnate cellular immune response that is mediated by the toll-like receptorpathway in A549 cells. Virology 2007; 358: 357-372.
45. Hartman ZC, Appledorn DM, Amalfitano A. Adenovirus vector induced innateimmune responses: impact upon efficacy and toxicity in gene therapy andvaccine applications. Virus Res 2008; 132: 1-14.
46. Babiuk S, Mookherjee N, Pontarollo R, Griebel P, van Drunen Littel-van den Hurk S,Hecker R et al. TLR9-/-and TLR9+/+ mice display similar immune responses to aDNA vaccine. Immunology 2004; 113: 114-120.
47. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display ofgenome-wide expression patterns. Proc Natl Acad Sci USA 1998; 95: 14863-14868.
48. Pfaffl MW. A new mathematical model for relative quantification in real-timeRT-PCR. Nucleic Acids Res 2001; 29: e45.