Altered Glucose Homeostasis Is Associated with Increased Serum Apelin Levels in Type 2 Diabetes Mellitus

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Cavallo, Maria Gisella ^b   Sentinelli, Federica ^a   Barchetta, Ilaria ^b   Costantino, Carmine ^b   Incani, Michela ^a   Perra, Laura ^a   Capoccia, Danila ^b   Romeo, Stefano ^a,c   Cossu, Efisio ^a   Leonetti, Frida ^b   Agati, Luciano ^b   Baroni, Marco G ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

APELIN; GLUCOSE;

ADULT; AGE; ARTICLE; BARIATRIC SURGERY; BASAL DISPOSITION INDEX; BODY MASS; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MEDICAL PARAMETERS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROTEIN BLOOD LEVEL;

ADULT; ANTHROPOMETRY; BARIATRIC SURGERY; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE; HOMEOSTASIS; HUMANS; HYPOGLYCEMIC AGENTS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LINEAR MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS;

EID: 84870839405     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051236     Document Type: Article

References (28)

1. Kahn SE, Hull RL, Utzschneider KM, (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444: 840-846.
2. Deng Y, Scherer PE, (2010) Adipokines as novel biomarkers and regulators of the metabolic syndrome. Ann N Y Acad Sci 1212: E1-E19.
3. Tatemoto K, Takayama K, Zou MX, Kumaki I, Zhang W, et al. (2001) The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept 99: 87-92.
4. Boucher J, Masri B, Daviaud D, Gesta S, Guigné C, et al. (2005) Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 146: 1764-1771.
5. Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, et al. (2003) Pharmacological and immunohistochemical characterization of APJ receptor and its endogenous ligand apelin. J Neurochem 84;1162-1172.
6. Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, et al. (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 251: 471-476.
7. El Messari S, Iturrioz X, Fassot C, De Mota N, Roesch D, et al. (2004) Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure. J Neurochem 90: 1290-1301.
8. Castan-Laurell I, Dray C, Knauf C, Kunduzova O, Valet P, (2012) Apelin, a promising target for type 2 diabetes treatment? Trends Endocrinol Metab 23: 234-241.
9. Attané C, Foussal C, Le Gonidec S, Benani A, Daviaud D, et al. (2012) Apelin treatment increases complete fatty acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes 61: 310-320.
10. Yue P, Jin H, Xu S, Aillaud M, Deng AC, et al. (2011) Apelin decreases lipolysis via Gq, Gi, and AMPKdependent mechanisms. Endocrinology 152, 59-68.
11. Attané C, Daviaud D, Dray C, Dusaulcy R, Masseboeuf M, et al. (2011) Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo. J. Mol. Endocrinol 46: 21-28.
12. Guo L, Li Q, Wang W, Yu P, Pan H, et al. (2009) Apelin inhibits insulin secretion in pancreatic beta-cells by activation of PI3-kinase-phosphodiesterase 3B. Endocr Res 34: 142-154.
13. Soriguer F, Garrido-Sanchez L, Garcia-Serrano S, Garcia-Almeida JM, Garcia-Arnes J, et al. (2009) Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus. Obes Surg 19: 1574-1580.
14. Dray C, Debard C, Jager J, Disse E, Daviaud D, et al. (2010) Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans. Am J Physiol Endocrinol Metab 298: E1161-E1169.
15. Erdem G, Dogru T, Tasci I, Sonmez A, Tapan S, (2008) Low plasma apelin levels in newly diagnosed type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 116: 289-292.
16. Zhang Y, Shen C, Li X, Ren G, Fan X, et al. (2009) Low plasma apelin in newly diagnosed type 2 diabetes in Chinese people. Diabetes Care 32: e150.
17. Meral C, Tascilar E, Karademir F, Tanju IA, Cekmez F, et al. (2010) Elevated plasma levels of apelin in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab 23: 497-502.
18. Telejko B, Kuzmicki M, Wawrusiewicz-Kurylonek N, Szamatowicz J, Nikolajuk A, et al. (2010) Plasma apelin levels and apelin/APJ mRNA expression in patients with gestational diabetes mellitus. Diabetes Res Clin Pract 87: 176-183.
19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
20. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, et al. (2005) Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive Summary. Circulation 112: e285-e290.
21. American Diabetes Association. Standards of medical care in diabetes-2009 (2009) Diabetes Care. 32: S13-S61.
22. Cobelli C, Toffolo GM, Dalla Man C, Campioni M, Denti P, et al. (2007) Assessment of b-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests. Am J Physiol Endocrinol Metab 293: E1-E15.
23. Bergman RN, Ader M, Huecking K, Van Citters G, (2002) Accurate assessment of beta-cell function: the hyperbolic correction. Diabetes 51 (Suppl 1): S212-20.
24. Yue P, Jin H, Aillaud M, Deng AC, Azuma J, et al. (2010) Apelin is necessary for the maintenance of insulin sensitivity. Am J Physiol Endocrinol Metab 298(1): E59-67.
25. Heinonen MV, Laaksonen DE, Karhu T, Karhunen L, Laitinen T, et al. (2009) Effect of diet-induced weight loss on plasma apelin and cytokine levels in individuals with the metabolic syndrome. Nutr Metab Cardiovasc Dis 19(9): 626-633.
26. Daviaud D, Boucher J, Gesta S, Dray C, Guigne C, et al. (2006) TNFalpha up-regulates apelin expression in human and mouse adipose tissue. FASEB J 20(9): 1528-1530.
27. Peterli R, Steinert RE, Woelnerhanssen B, Peters T, Christoffel-Courtin C, et al. (2012) Metabolic and hormonal changes after laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: a randomized, prospective trial. Obes Surg 22(5): 740-748.
28. Ramón JM, Salvans S, Crous X, Puig S, Goday A, et al. (2012) Effect of Roux-en-Y gastric bypass vs sleeve gastrectomy on glucose and gut hormones: a prospective randomised trial. J Gastrointest Surg 16(6): 1116-1122.