Autologous intravenous mononuclear stem cell therapy in chronic ischemic stroke

Journal of Stem Cells and Regenerative Medicine

Volumn 8, Issue 3, 2012, Pages 181-189

  Bhasin, A ^a   Srivastava, M V ^a   Bhatia, R ^a   Mohanty, S ^a   Kumaran, S S ^a   Bose, S ^b  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Cell transplantation; Functional Recovery; Mononuclear Stem Cells; Neuroimaging; Stroke

Indexed keywords

ADULT; ARTICLE; AUTOLOGOUS INTRAVENOUS MONONUCLEAR STEM CELL TRANSPLANTATION; AUTOLOGOUS STEM CELL TRANSPLANTATION; BARTHEL INDEX; BRAIN ISCHEMIA; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; DIFFUSION TENSOR IMAGING; FEASIBILITY STUDY; FEMALE; FOLLOW UP; FUNCTIONAL ASSESSMENT; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL STATUS; HAND MUSCLE; HUMAN; MALE; MUSCLE STRENGTH; MUSCLE TONE; NERVE CELL PLASTICITY; OBSERVATIONAL STUDY; PATIENT SAFETY; PHYSIOTHERAPY; PRIMARY MOTOR CORTEX;

EID: 84870799367     PISSN: 09737154     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Sethi PK. Stroke-Incidence in India and management of ischemic stroke. Neurosciences. 2002; 3: 202-206.
2. Banerjee T, Das S. Epidemiology of stroke in India. Neurology Asia. 2006; 11: 1-4.
3. Locatelli F, Bersano A, Strazzer S, Bresolin N, Corti S. Stem cell therapy in stroke: Review. Cell Mol Life Sci. 2009; 66: 757-772.
4. Kondziolka D, Wechsler L, Meltzer C, Goldstein S. Transplantation of cultured neuronal cells for patients with stroke. Neurology. 2000; 55: 565-570.
5. Savitz SI, Dinsmore J, Wu S. Neural transplantation of fetal porcine cells in patients with basal ganglia infarcts; a preliminary safety and feasibility study. Cerebrovas Dis. 2005; 2: 101-112.
6. Bang YO, Lee JS, Lee PH. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol. 2005; 57: 874-881.
7. Rabinovich SS, Seledtsov VI, Banul NV. Cell therapy for brain stroke. Bull Exp Biol Med. 2005; 139: 126-134.
8. Bergado JA, Monteagudo CS, Ramirez PH, Gonzalez RM. Autologous bone marrow stem cell transplantation in stroke patients. An open study. Restorative Neurology and Neuroscience. 2009; 27: 151-161.
9. Morrison SJ, Uchida N, Weissman IL. The biology of hematopoietic stem cells. Annu Rev Cell Dev Biol. 1995; 11: 35-71.
10. Domen J, Weissman IL. Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fate. Mol Med Today. 1995; 5: 201-208.
11. Machalinski B, Paczkowska E, Koziarska D, Ratajczak MZ. Mobilization of human hematopoietic stem/progenitorenriched CD34+ cells into peripheral blood during stress related to ischemic stroke. Folia Histochemica et Cytobiologica. 2006; 44(2): 97-101.
12. Kelly S, Bliss TM, Shah AK, Sun GH, Foo WC. Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex. Proc Natl Acad Sci U S A. 2004; 101(32): 11839-11844.
13. Shintani S, Murohara T, Ikeda H, Ueno T. Augmentation of Postnatal Neovascularization With Autologous Bone Marrow Transplantation. Circulation. 2001; 103: 897-903.
14. Schwarting S, Litwak S, Hao W, Bähr M, Weise J, Neumann H. Hematopoietic Stem Cells Reduce Postischemic Inflammation and Ameliorate Ischemic Brain Injury. Stroke. 2008; 39: 2867-2875.
15. www.clinicaltrials.gov/ct2/show/NCT00761982.
16. www.clinicaltrials.gov/ct2/show/NCT00535197.
17. Brennemann M, Sharma S, Harting M, Strong R, Cox CS. Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle aged rats. Journal of Cerebral Blood flow and metabolism 2010; 30:140-149.
18. Cramer SC. Repairing the human brain after stroke: II Restorative therapies. Ann Neurol. 2008; 63: 549-560.
19. Padma MV. Restorative therapy in stroke using for stem cells. Neurology India. 2009; 4: 381-386.
20. Nudo RJ, Milliken GW, Jenkins WM, Merzenich MM. Usedependent alterations of movement representations in primary motor cortex of adult squirrel monkeys. J Neurosci. 1996;16: 785-807.
21. Calautti C, Baron J. Functional neuroimaging studies of motor recovery after stroke in adults: a review. Stroke. 2003; 34: 1553-1566.
22. Cho SH, Kim DG, Kim DS, Kim YH. Motor outcome according to the integrity of the corticospinal tract determined by diffusion tensor tractography in the early stage of corona radiata infarct. Neuroscience Letters. 2007; 426: 123-127.
23. Bliss T, Guzman R, Daadi M, Steinberg GK. Cell Transplantation Therapy for Stroke. Stroke. 2007; 38:817-826.
24. Shen LH, Li Y, Chen J, Zhang J, Vanguri P, Borneman J, Chopp M. Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodelling after stroke. Neuroscience. 2006; 137: 393-399.
25. Steindler DA. Neural stem cells, scaffolds and chaperones. Nature. 2002; 20: 1091-1093.
26. Loewen SC, Anderson BA. Reliability of motor assessment and Barthel Index. Phy Ther. 1999; 8:1077-1081.
27. Ismail S, Bilger Y, Evren Y, Rdvani A. Brunnstrom recovery stage and motricity index for the evaluation of upper extremity in stroke: analysis for correlation and responsiveness. International Journal of Rehabilitation Research. 2009; 32(3): 228-231.
28. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1972; 9: 97-113.
29. Gaggioli, A., Meneghini, A., Morganti, F. A Strategy for Computer-Assisted Mental Practice in Stroke Rehabilitation. Neurorehabil Neural repair. 2006; 20: 503-507.
30. Maeda F, Kleiner-Fisman G, Pascual-Leone A. Motor facilitation while observing hand actions: specificity of the effect and role of observer's orientation. J Neurophysiol. 2002; 87: 1329-1335.
31. Steiner CM, Barber PA, Smale PR. Functional potential in chronic stroke patients depends on corticospinal tract integrity. Brain. 2007; 130: 170-180.
32. Feydy A, Carlier R, Brami AR, Bussel B, Cazalis F, Pierot L, Burnod LY, Maier MA. Longitudinal Study of Motor Recovery After Stroke Recruitment and Focusing of Brain Activation. Stroke. 2002; 33: 1610-1617.
33. Small SL, Hlustik P, Noll DC. Cerebellar hemispheric activation ipsilateral to the paretic hand correlates with functional recovery after stroke. Brain. 2002;125: 1544-1557.
34. Nair DG, Fuchs A, Burkart S, Steinberg FL, Kelso JAS. Assessing middle cerebral artery after Stroke. Brain Injury. 2005; 19(13): 1165-1176)
35. Moller M, Frandsen J. Dynamic changes in corticospinal tracts after stroke detected by fibre tracking. J Of Neurol Neurosurg Psychiatry. 2007; 78: 587-592.
36. Komitova M, Mattsson B. Enriched environment increases neural stem/progenitor cell proliferation and neurogenesis in the stroke lesioned adult rats. Stroke. 2005; 36: 1287-1282.
37. Willing A, Lixian J, Milliken M, Poulus S. Intravenous versus intrastriatal cord blood administration in a rodent model of stroke. J of Neurosci. 2009; 9: 296-307.
38. Chen J, Wang S. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res. 2003; 92: 1-10.
39. Shen SH, Zang Z, Lu M. Therpaeutic benefit of bone marrow stromal cells administered 1 month after stroke. J of Cerebral Blood flow and metabolism. 2007; 27: 6-13.
40. Jin K, Zhu Y, Sun Y. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci USA. 2002; 99: 11946-11950.
41. Wechsler L, Steindler D, Borlongan C, Chopp M, Caplan L, Hess D. Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS) Bridging Basic and Clinical Science for Cellular and Neurogenic Factor Therapy in Treating Stroke. Stroke. 2009; 40: 510-515.