Interactions with host cells causes Neisseria meningitidis pili to become unglued

Frontiers in Microbiology

Volumn 2, Issue APR, 2011, Pages

  Chen, Adrienne ^a   Seifert, H Steven ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84870789917     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2011.00066     Document Type: Article

References (10)

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2. Chamot-Rooke, J., Mikaty, G., Malosse, C., Soyer, M., Dumont, A., Gault, J., Imhaus, A.F., Martin, P., Trellet, M., Clary, G., Chafey, P., Camoin, L., Nilges, M., Nassif, X., and Dumenil, G. (2011). Posttranslational modification of pili upon cell contact triggers N. meningitidis dissemination. Science 331, 778-782.
3. Forest, K. T., Dunham, S. A., Koomey, M., and Tainer, J. A. (1999). Crystallographic structure reveals phosphorylated pilin from Neisseria: phosphoserine sites modify type IV pilus surface chemistry and fibre morphology. Mol. Microbiol. 31, 743-752.
4. Hegge, F. T., Hitchen, P. G., Aas, F. E., Kristiansen, H., Lovold, C., Egge-Jacobsen, W., Panico, M., Leong, W. Y., Bull, V., Virji, M., Morris, H. R., Dell, A., and Koomey, M. (2004). Unique modifications with phosphocholine and phosphoethanolamine define alternate antigenic forms of Neisseria gonorrhoeae type IV pili. Proc. Natl. Acad. Sci. U.S.A. 101, 10798-10803.
5. Higashi, D. L., Lee, S. W., Snyder, A., Weyand, N. J., Bakke, A., and So, M. (2007). Dynamics of Neisseria gonorrhoeae attachment: microcolony development, cortical plaque formation, and cytoprotection. Infect. Immun. 75, 4743-4753.
6. Marceau, M., Beretti, J. L., and Nassif, X. (1995). High adhesiveness of encapsulated Neisseria meningitidis to epithelial cells is associated with the formation of bundles of pili. Mol. Microbiol. 17, 855-863.
7. Marceau, M., Forest, K., Beretti, J. L., Tainer, J., and Nassif, X. (1998). Consequences of the loss of O-linked glycosylation of meningococcal type IV pilin on piliation and pilus-mediated adhesion. Mol. Microbiol. 27, 705-715.
8. Stimson, E., Virji, M., Barker, S., Panico, M., Blench, I., Saunders, J., Payne, G., Moxon, E. R., Dell, A., and Morris, H. R. (1996). Discovery of a novel protein modification: alpha- glycerophosphate is a substituent of meningococcal pilin. Biochem. J. 316, 29-33.
9. Stimson, E., Virji, M., Makepeace, K., Dell, A., Morris, H. R., Payne, G., Saunders, J. R., Jennings, M. P., Barker, S., Panico, M., Blench, I., and Moxon, E. R. (1995). Meningococcal pilin: a glycoprotein substituted with digalactosyl 2,4-diacetamido-2,4,6-trideoxyhexose. Mol. Microbiol. 17, 1201-1214.
10. Warren, M. J., and Jennings, M. P. (2003). Identification and characterization of pptA: a gene involved in the phase-variable expression of phosphorylcholine on pili of Neisseria meningitidis. Infect. Immun. 71, 6892-6898.