Management of post-traumatic nightmares: A review of pharmacologic and nonpharmacologic treatments since 2010

Current Psychiatry Reports

Volumn 14, Issue 5, 2012, Pages 529-535

  Escamilla, Monica ^a   LaVoy, Mercedes ^a   Moore, Bret A ^a,b   Krakow, Barry ^c  

^a SAN ANTONIO MILITARY MEDICAL CENTER   (United States)

^b Trauma Risk and Resiliency Fellowship Warrior Resiliency Program ^*  (United States)

^c Maimonides Sleep Arts and Sciences Ltd   (United States)

Author keywords

Behavioral treatments; Pharmacologic treatments; Post traumatic nightmares; Post traumatic stress disorder; Psychiatry; PTSD; Sleep disorders; Sleep treatments; Trauma

Indexed keywords

CARVEDILOL; ESCITALOPRAM; ESZOPICLONE; GABAPENTIN; HYDROCORTISONE; OXYBATE SODIUM; PAROXETINE; PLACEBO; PRAZOSIN; RISPERIDONE; TETRAHYDROCANNABINOL; TRAZODONE; ZOLPIDEM;

COGNITIVE THERAPY; DIARY RECORDING; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SELECTIVITY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EXPOSURE RELAXATION AND RESCRIPTING THERAPY; EXPOSURE TREATMENT; HAND TREMOR; HUMAN; IMAGE REHEARSAL THERAPY; IMAGERY RESCRIPTING AND EXPOSURE THERAPY; INSOMNIA; LOW DRUG DOSE; LUCID DREAMING THERAPY; MAJOR DEPRESSION; NAUSEA; NIGHTMARE; POSTTRAUMATIC NIGHTMARE; POSTTRAUMATIC STRESS DISORDER; PSYCHOTHERAPY; REVIEW; SEDATION; SELF HELP; SIDE EFFECT; SLEEP HYGIENE; THERAPY EFFECT; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; VOMITING;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; COMBINED MODALITY THERAPY; DREAMS; HUMANS; PSYCHOTHERAPY; SLEEP DISORDERS; STRESS DISORDERS, POST-TRAUMATIC;

EID: 84870786131     PISSN: 15233812     EISSN: 15351645     Source Type: Journal    
DOI: 10.1007/s11920-012-0306-7     Document Type: Review

References (59)

1. Belanger J, Dalley K. The Nightmare Encyclopedia: your darkest dreams interpreted. Franklin Lakes, NJ: The Career Press; 2006.
2. Moore BA, Krakow B. Imagery rehearsal therapy: an emerging treatment for post-traumatic nightmares in veteran's psychological trauma. Theor Res Pract Policy. 2010;2:232-8.
3. Belicki D, Belicki K. Nightmares in a university population. Sleep Res. 1982;11:116.
4. Belicki K, Belicki D. Predisposition for nightmares: a study of hypnotic ability, vividness of imagery, and absorption. J Clin Psychol. 1986;42:714-8. (Pubitemid 16026604)
5. Feldman MJ, Hersen M. Attitudes toward death in nightmare subjects. J Abnorm Psychol. 1967;72:421-5.
6. Levin R. Sleep and dreaming characteristics of frequent nightmare subjects in a university population. Dreaming. 1994;4:127-37.
7. Wood J, Bootzin R. The prevalence of nightmares and their independence from anxiety. J Abn Psychol. 1990;99:64-8. (Pubitemid 20117088)
8. Nielsen TA, Zadra AL. Dreaming disorders in principles and practices in sleep medicine. In: Kryger MH, Roth T, Dement WC, editors. Principle and practices of sleep medicine. 3rd ed. Philadelphia: WB Saunders; 2000.
9. Barrett D. Trauma and dreams. Cambridge, MA: Harvard University Press; 1996.
10. Lifton JR, Olsen E. The human meaning of total disaster: the Buffalo Creek experience. Psychiatry. 1976;39:1-18.
11. Low JF, Dyster-Aas J, Willebrand M, Kildal M, Gerdin B, Ekselius L. Chronic nightmares after severe burns: risk factors and implications for treatment. J Burn Care Rehabil. 2003;24:260-7. (Pubitemid 36871352)
12. Kilpatrick DG, Resnick HS, Freedy JR, Pelcovitz D, Resick P, Roth S, et al. Post-traumatic stress disorder field trial: evaluation of the PTSD construct? Criteria A through E. In:Widiger TA, Frances AJ, Pincus HA, Ross R, First MB, Davis W, editors. DSM-IV sourcebook, vol. 4. Washington, DC: American Psychiatric Association Press; 1998. p. 803-6.
13. Krakow B, Melendrez D, Pedersen B, Johnston L, Hollifield M, Germain A, et al. Complex insomnia: insomnia and sleepdisordered breathing in a consecutive series of crime victims with nightmares and PTSD. Biol Psychiatry. 2001;49:948-53. (Pubitemid 32493817)
14. Ross RJ, Ball WA, Sullivan KA, Caroff SN. Sleep disturbance as the hallmark of post-traumatic stress disorder. Am J Psychiatry. 1989;146:697-707. (Pubitemid 19149579)
15. DeViva JC, Zayfert C, Mellman TA. Factors associated with insomnia among civilians seeking treatment for PTSD: an exploratory study. Behav Sleep Med. 2004;2:162-76.
16. Krakow B, Hollifield M, Schrader R, Koss M, Tandberg D, Lauriello J, et al. A controlled study of imagery rehearsal for chronic nightmares in sexual assault survivors with PTSD: a preliminary report. J Trauma Stress. 2000;13:589-609.
17. Zayfert C, DeViva JC. Residual insomnia following cognitive behavioral therapy for PTSD. J Trauma Stress. 2004;17:69-73. (Pubitemid 38280767)
18. University of Maryland. Sleep disorders. Available at: http://www.umm.edu/sleep/sleep-dis-main.htm. Accessed on February 2012.
19. Spoormarker VI, Montgomery P. Disturbed sleep in post-traumatic stress disorder: secondary symptoms or core feature. Sleep Med Rev. 2008;12:169-84.
20. American Academy of Sleep Medicine. Nightmares. Available at: http://yoursleep.aasmnet.org/disorder.aspx?id037. Accessed February 2012.
21. Moore BA, Krakow B. Characteristics, effects, and treatment of sleep disorders in service members. In: Freeman MS, Moore BA, Freeman A, editors. Living and surviving in harm's way: a psychological treatment handbook for pre- and post-deployment of military personnel. New York, NY: Routledge; 2009. p. 281-306.
22. Armenian Medical Network. Nightmare disorder (formerly dream anxiety disorder). Available at: http://sleep.health.am/sleep/more/nightmare-disorder/. Accessed February 2012.
23. Moore BA, Kraków B. Imagery rehearsal therapy: an emerging treatment for post-traumatic nightmares in veterans. Psychol Trauma Theory Res Pract Policy. 2010;2(3):232-8.
24. Aurora RN, Zak RS, Auerbach SH, Casey KR, Chowdhuri S, Karripot A, et al. Best practice guide for the treatment of nightmares disorder in adults. J Clin Sleep Med. 2010;6(4):389-401.
25. Phillips B, Ball C, Sackett D, Badenoch B, Straus S, Haynes M, et al. Oxford Centre for Evidence-based Medicine - Levels of Evidence. Available at: http://www.cebm.net/index.aspx?o01025. Accessed February 2012.
26. Fitch K, Bernstein SJ, Aguilar MD, Burnand B, LaCalle JR, Lazaro P, et al. The RAND/UCLA appropriateness method user's manual. Santa Monica, CA: RAND; 2001.
27. Taylor FB, Martin P, Thompson C, Williams J, Mellman TA, Gross C, et al. Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma PTSD: a placebo-controlled study. Biol Psychiatry. 2008;63:629-32. (Pubitemid 351273194)
28. Ross RJ, Gresch PJ, Ball WA, Sanford LD, Morrison AR. REM sleep inhibition by desipramine: evidence for an α-1 adrenergic mechanism. Brain Res. 1995;701:129-34.
29. Taylor F, Raskind MA. The alpha1-adrenergic antagonist prazosin improves sleep and nightmares in civilian trauma post-traumatic stress disorder. J Clin Psychopharmacol. 2002;22:82-5. (Pubitemid 34101296)
30. Calohan J, Peterson K, Peskind EP, Raskind MA. Prazosin treatment of trauma nightmares and sleep disturbance in soldiers deployed in Iraq. J Trauma Stress. 2010;23:645-8.
31. Guy W. ECDEU Assessment manual for psychopharmacology. ADM 76-338, Rockville, MD: U.S. Department of Health, Education and Welfare; 1976. p. 218-22.
32. Blake DD, Weathers FW, Nagy LL, Kaloupek DG, Gusman FD, Charney DS, et al. The development of a clinician-administered PTSD scale. J Trauma Stress. 1995;8:75-90.
33. Raskind MA, Peskind ER, Kanter ED, Petrie EC, Radant A, Thompson CE, et al. Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study. Am J Psychiatry. 2003;160:371-3. (Pubitemid 41110467)
34. Germain A, Richardson R, Moul DE, Mammen O, Haas G, Forman SD, et al. Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances in US military veterans. J Psychosom Res. 2012;72:89-96.
35. Khachiyants N, Ali R, Kovesdy CP, Detweiler JG, Kim KY, Detweiler MB. Effectiveness of risperidone for the treatment of nightmares in veterans with post-traumatic stress disorder. J Clin Psychopharmacol. 2010;30:735-7.
36. Ahern EP, Krohn A, Connor KN, Davidson JR. Pharmacologic treatment of post-traumatic stress disorder. a focus on antipsychotic use. Ann Clin Psychiatr. 2003;15:193-201. (Pubitemid 38176339)
37. Raskin MA, Peskind ER, Kanter ED, Petrie EC, Radant A, Thompson CE, et al. Reduction of PTSD nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study. Am J Psychiatry. 2003;160:371-3. (Pubitemid 41110467)
38. Krystal AD, Davidson JRT. The use of prazosin for the treatment of trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry. 2007;61:925-7. (Pubitemid 46482467)
39. Detweiler MB, Khachiyants N, Detweiler JG, Ali R, Kim KY. Risperidone for post-traumatic combat nightmares: a report of 4 cases. Consult Pharm. 2011;26:920-8.
40. Attarian H. Treatment options for parasomnias. Neurol Clin. 2010;28:1089-106.
41. Tien-Chun L, Pi-Yu S, Hsiu-Wen C, Chia-Ho P. Trazodone ameliorates nightmares in major depressive disorder. J Neuropsychiatry Clin Neurosci. 2011;23:E4.
42. Bajor LA, Ticlea AN, Osser DN. The psychopharmacology algorithm project at the Harvard south shore program: an update on posttraumatic stress disorder. Harv Rev Psychiatr. 2011;19:240-58.
43. U.S. National Institutes of health. Clinical trials.gov. Available at: http://www.clinicaltrials.gov/ct2/results?term0nightmares+treatment. Accessed February 2012.
44. Davis JL, Pruiksma KE, Rhudy JL, Byrd P. A comparison of lifelong and post-trauma nightmares in a civilian trauma sample: nightmare characteristics, psychopathology, and treatment outcome. Dreaming. 2011;21:70-80.
45. Krakow B, Zadra A. Clinical management of chronic nightmares: imagery rehearsal therapy. Behav Sleep Med. 2006;4(1):45-70.
46. Nappi CM, Drummond SP, Hall JM. Treating nightmares and insomnia in post-traumatic stress disorder: a review of current evidence. Neuropharmacology. 2012;62:576-85.
47. Nappi CM, Drummond SP, Thorp SR, McQuaid Jr. Effectiveness of imagery rehearsal therapy for the treatment of combat-related nightmares in veterans. Behav Ther. 2010;41:237-44.
48. Lancee J, Spoormaker VI, van den Bout J. Cognitive-behavioral self-help treatment for nightmares: a randomized controlled trial. Psychother Psychosom. 2010;79:371-7.
49. Lancee J, van den Bout J, Spoormaker VI. Expanding self-help imagery rehearsal therapy for nightmares with sleep hygiene and lucid dreaming: a waiting-list controlled trial. Int J Dream Res. 2010;3:111-20.
50. Cook JM, Harb GC, Gehrman PR, Cary MS, Gamble GM, Forbe I, et al. Imagery rehearsal for post-traumatic nightmares: a randomized controlled trial. J Trauma Stress. 2010;23:553-63.
51. Ulmer CS, Edinger JD, Calhoun PS. A multi-component cognitive-behavioral intervention for sleep disturbance in veterans with PTSD: a pilot study. J Clin Sleep Med. 2011;7:57-68.
52. Davis JL, Rhudy JL, Pruiksma KE, Bryd P, Williams AE, MsCabe KM, et al. Physiological predictors of response to exposure, relaxation, and rescripting therapy for chronic nightmares in a randomized clinical trial. J Clin Sleep Med. 2011;7:622-63.
53. Rhudy JL, Davis JL, Williams AE, MsCabe KM, Bartley EJ, Bryd P, et al. Cognitive-behavioral treatment for chronic nightmares in trauma-exposed persons: assessing physiological reactions to nightmare-related fear. J Clin Psychol. 2010;66:365-82.
54. Wanner J, Long ME, Teng EJ. Multi-component treatment for post-traumatic nightmares in Vietnam veterans: 2 case studies. J Psychiatr Pract. 2010;16:243-9.
55. Long ME, Davis JL, Springer JR, et al. The role of cognitions in imagery rescripting for post-traumatic nightmares. J Clin Psychol. 2011;67:1008-16.
56. Long ME, Hammons ME, Davis JL, Frueh BC, Khan MM, Elhai JD, et al. Imagery rescripting and exposure group treatment of post-traumatic nightmares in Veterans with PTSD. J Anxiety Disord. 2011;25:531-5.
57. Lancee J, Spoormaker VI, van den Bout J. Long-term effectiveness of cognitive-behavioral self-help intervention for nightmares. J Sleep Res. 2011;20:454-9.
58. Been G, Garg V. Nightmares in the context of PTSD treated with psychoeducation regarding lucid dreaming. Aust N Z J Psychiatr. 2010;44:583.
59. Gehrman PR, Harb GC. Treatment of nightmares in the context of post-traumatic stress disorder. J Clin Psychol. 2010;66:1185-94.