Determining the optimal cut-off value of the urinary albumin-to-creatinine ratio to detect atherosclerotic vascular diseases

Kidney and Blood Pressure Research

Volumn 36, Issue 1, 2012, Pages 290-300

  Lee, Young Hoon ^a,b   Kweon, Sun Seog ^c,d   Choi, Jin Su ^c   Rhee, Jung Ae ^c   Nam, Hae Sung ^e   Jeong, Seul Ki ^f   Park, Kyeong Soo ^g   Kim, Hye Yeon ^g   Ryu, So Yeon ^h   Choi, Seong Woo ^h   Kim, Bok Hee ⁱ   Shin, Min Ho ^c  

^a Wonkwang University School of Medicine   (South Korea)

^b Wonkwang University Hospital   (South Korea)

^c Chonnam National University Medical School   (South Korea)

^d Chonnam National University   (South Korea)

^e Chungnam National University   (South Korea)

^f Chonbuk National University Medical School   (South Korea)

^g Seonam University   (South Korea)

^h Chosun University College of Medicine   (South Korea)

ⁱ Chosun University   (South Korea)

Author keywords

Albuminuria; Arterial stiffness; Atherosclerosis; Carotid artery

Indexed keywords

ALBUMIN; CREATININE;

AGED; ALBUMIN TO CREATININE RATIO; ANKLE BRACHIAL INDEX; AREA UNDER THE CURVE; ARTERIAL WALL THICKNESS; ARTICLE; B SCAN; CALCULATION; CAROTID ATHEROSCLEROSIS; COMMON CAROTID ARTERY; CONTROLLED STUDY; CREATININE URINE LEVEL; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; KOREA; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; PERIPHERAL OCCLUSIVE ARTERY DISEASE; POPULATION RESEARCH; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULSE WAVE; RENAL SYSTEM PARAMETERS; SENSITIVITY AND SPECIFICITY;

AGED; ALBUMINS; ALBUMINURIA; ANKLE BRACHIAL INDEX; ATHEROSCLEROSIS; CAROTID ARTERIES; CAROTID INTIMA-MEDIA THICKNESS; CREATININE; FEMALE; HEALTH SURVEYS; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PULSE WAVE ANALYSIS; REFERENCE STANDARDS; REPUBLIC OF KOREA; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84870748003     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000343418     Document Type: Article

References (30)

1. Keane WF, Eknoyan G: Proteinuria, albuminuria, risk, assessment, detection, elimination (PARADE): a position paper of the National Kidney Foundation. Am J Kidney Dis 1999;33:1004-1010.
2. Hillege HL, Fidler V, Diercks GF, van Gilst WH, de Zeeuw D, van Veldhuisen DJ, Gans RO, Janssen WM, Grobbee DE, de Jong PE, Prevention of Renal and Vascular End Stage Disease (PREVEND) Study Group: Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population. Circulation 2002;106:1777-1782.
3. Arnlöv J, Evans JC, Meigs JB, Wang TJ, Fox CS, Levy D, Benjamin EJ, D'Agostino RB, Vasan RS: Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study. Circulation 2005;112:969-975.
4. Klausen K, Borch-Johnsen K, Feldt-Rasmussen B, Jensen G, Clausen P, Scharling H, Appleyard M, Jensen JS: Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes. Circulation 2004;110:32-35.
5. Ratto E, Leoncini G, Viazzi F, Vaccaro V, Parodi A, Falqui V, Bezante GP, Tomolillo C, Deferrari G, Pontremoli R: Microalbuminuria and cardiovascular risk assessment in primary hypertension: should threshold levels be revised? Am J Hypertens 2006;19:728-734.
6. Jørgensen L, Jenssen T, Johnsen SH, Mathiesen EB, Heuch I, Joakimsen O, Fosse E, Jacobsen BK: Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in non-diabetic persons: the Tromsø Study. Eur Heart J 2007;28:363-369.
7. Yokoyama H, Aoki T, Imahori M, Kuramitsu M: Subclinical atherosclerosis is increased in type 2 diabetic patients with microalbuminuria evaluated by intima-media thickness and pulse wave velocity. Kidney Int 2004;66:448-454.
8. Bigazzi R, Bianchi S, Nenci R, Baldari D, Baldari G, Campese VM: Increased thickness of the carotid artery in patients with essential hypertension and microalbuminuria. J Hum Hypertens 1995;9:827-833.
9. Furtner M, Kiechl S, Mair A, Seppi K, Weger S, Oberhollenzer F, Poewe W, Willeit J: Urinary albumin excretion is independently associated with carotid and femoral artery atherosclerosis in the general population. Eur Heart J 2005;26:279-287.
10. Kramer H, Jacobs DR Jr, Bild D, Post W, Saad MF, Detrano R, Tracy R, Cooper R, Liu K: Urine albumin excretion and subclinical cardiovascular disease. The Multi-Ethnic Study of Atherosclerosis. Hypertension 2005;46:38-43.
11. Liu CS, Pi-Sunyer FX, Li CI, Davidson LE, Li TC, Chen W, Lin CC, Huang CY, Lin WY: Albuminuria is strongly associated with arterial stiffness, especially in diabetic or hypertensive subjects-a population-based study (Taichung Community Health Study, TCHS). Atherosclerosis 2010;211:315-321.
12. Munakata M, Nunokawa T, Yoshinaga K, Toyota T, J-TOPP Study Group: Brachial-ankle pulse wave velocity is an independent risk factor for microalbuminuria in patients with essential hypertension-a Japanese trial on the prognostic implication of pulse wave velocity (J-TOPP). Hypertens Res 2006;29:515-521.
13. Kim BJ, Lee HA, Kim NH, Kim MW, Kim BS, Kang JH: The association of albuminuria, arterial stiffness, and blood pressure status in nondiabetic, nonhypertensive individuals. J Hypertens 2011;29:2091-2098.
14. Ishikawa T, Hashimoto J, Morito RH, Hanazawa T, Aikawa T, Hara A, Shintani Y, Metoki H, Inoue R, Asayama K, Kikuya M, Ohkubo T, Totsune K, Hoshi H, Satoh H, Imai Y: Association of microalbuminuria with brachial-ankle pulse wave velocity: the Ohasama study. Am J Hypertens 2008;21:413-418.
15. Choi SW, Kim HY, Lee YH, Ryu SY, Kweon SS, Rhee JA, Choi JS, Shin MH: eGFR is associated with subclinical atherosclerosis independent of albuminuria: the Dong-gu Study. Atherosclerosis 2010;212:661-667.
16. Selvin E, Erlinger TP: Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey 1999-2000. Circulation 2004;110:738-743.
17. Klausen KP, Scharling H, Jensen G, Jensen JS: New definition of microalbuminuria in hypertensive subjects: association with incident coronary heart disease and death. Hypertension 2005;46:33-37.
18. Rodondi N, Yerly P, Gabriel A, Riesen WF, Burnier M, Paccaud F, Bovet P: Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis in middle-aged adults. Nephrol Dial Transplant 2007;22:1107-1114.
19. Sung JK, Kim JY, Youn YJ, Lee JW, Ahn SG, Yoo BS, Lee SH, Yoon J, Choe KH, Yoon JH, Park JK, Koh SB: Urine Albumin Creatinine Ratio is Associated with Carotid Atherosclerosis in a Community Based Cohort: Atherosclerosis Risk of Rural Area in Korean General Population Study. J Cardiovasc Ultrasound 2010;18:134-138.
20. Huang Y, Chen Y, Xu M, Gu W, Bi Y, Li X, Ning G: Low-grade albuminuria is associated with carotid intima-media thickness in Chinese type 2 diabetic patients. J Clin Endocrinol Metab 2010;95:5122-5128.
21. Labropoulos N, Zarge J, Mansour MA, Kang SS, Baker WH: Compensatory arterial enlargement is a common pathobiologic response in early atherosclerosis. Am J Surg 1998;176:140-143.
22. Hermans MM, Henry RM, Dekker JM, Nijpels G, Heine RJ, Stehouwer CD: Albuminuria, but not estimated glomerular filtration rate, is associated with maladaptive arterial remodeling: the Hoorn Study. J Hypertens 2008;26:791-797.
23. Lehmann ED: Clinical value of aortic pulse-wave velocity measurement. Lancet 1999;354:528-529.
24. Laurent S, Boutouyrie P: Arterial stiffness: a new surrogate end point for cardiovascular disease? J Nephrol 2007;20:S45-S50.
25. Abbott RD, Petrovitch H, Rodriguez BL, Yano K, Schatz IJ, Popper JS, Masaki KH, Ross GW, Curb JD: Ankle/brachial blood pressure in men >70 years of age and the risk of coronary heart disease. Am J Cardiol 2000;86:280-284.
26. Vogt MT, Cauley JA, Newman AB, Kuller LH, Hulley SB: Decreased ankle/arm blood pressure index and mortality in elderly women. JAMA 1993;270:465-469.
27. Kallio M, Forsblom C, Groop PH, Groop L, Lepäntalo M: Development of new peripheral arterial occlusive disease in patients with type 2 diabetes during a mean follow-up of 11 years. Diabetes Care 2003;26:1241-1245.
28. Wattanakit K, Folsom AR, Criqui MH, Kramer HJ, Cushman M, Shea S, Hirsch AT: Albuminuria and peripheral arterial disease: results from the multi-ethnic study of atherosclerosis (MESA). Atherosclerosis 2008;201:212-216.
29. Wu CK, Yang CY, Tsai CT, Chiu FC, Huang YT, Lee JK, Cheng CL, Lin LY, Lin JW, Hwang JJ, Chiang FT: Association of low glomerular filtration rate and albuminuria with peripheral arterial disease: the National Health and Nutrition Examination Survey, 1999-2004. Atherosclerosis 2010;209:230-234.
30. Brouwers FP, Asselbergs FW, Hillege HL, de Boer RA, Gansevoort RT, van Veldhuisen DJ, van Gilst WH: Long-term effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria: Ten years of follow-up of Prevention of Renal and Vascular End-stage Disease Intervention Trial (PREVEND IT). Am Heart J 2011;161:1171-1178.