Urinary ketone is associated with the heart failure severity

Clinical Biochemistry

Volumn 45, Issue 18, 2012, Pages 1697-1699

  Chung, Ji Hyung ^a   Kim, Jin Sup ^b   Kim, Oh Yoen ^c   Kang, Seok Min ^a   Hwang, Geum Sook ^b   Shin, Min Jeong ^d  

^a Yonsei University College of Medicine   (South Korea)

^b Chungnam National University   (South Korea)

^c Dong A University   (South Korea)

^d Korea University   (South Korea)

Author keywords

Echocardiography; Ejection fraction; Heart failure; Ketones; Urine

Indexed keywords

1 METHYLNICOTINAMIDE; ACETIC ACID; ACETOACETIC ACID; ACETONE; CYTOSINE; GLYCINE DERIVATIVE; KETONE; METHYLMALONIC ACID; PHENYLACETYLGLYCINE; UNCLASSIFIED DRUG; URIC ACID;

AGED; ARTICLE; BLOOD FLOW VELOCITY; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ECHOCARDIOGRAPHY; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; MALE; PRIORITY JOURNAL; SYSTOLIC HEART FAILURE; URIC ACID URINE LEVEL; URINALYSIS; URINE LEVEL;

AGED; FEMALE; HEART FAILURE; HUMANS; KETONES; MALE; NEW YORK; REGRESSION ANALYSIS; SEVERITY OF ILLNESS INDEX; STROKE VOLUME;

EID: 84870724943     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2012.08.013     Document Type: Article

References (14)

1. Bui A.L., Horwich T.B., Fonarow G.C. Epidemiology and risk profile of heart failure. Nat Rev Cardiol 2011, 8(1):30-41.
2. Braunwald E. Biomarkers in heart failure. N Engl J Med 2008, 358(20):2148-2159.
3. van Kimmenade R.R., Januzzi J.L. Emerging biomarkers in heart failure. Clin Chem 2012, 58(1):1127-1138.
4. 1H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure. Clin Biochem 2011, 44(4):293-299.
5. 1H NMR metabolomics data. Anal Chem 2006, 78(13):4430-4442.
6. Kupari M., Lommi J., Ventila M., Ventilä M., Karjalainen U. Breath acetone in congestive heart failure. Am J Cardiol 1995, 76(14):1076-1078.
7. Lommi J., Kupari M., Koskinen P., Näveri H., Leinonen H., Pulkki K., et al. Blood ketone bodies in congestive heart failure. J Am Coll Cardiol 1996, 28(3):665-672.
8. Lopes-Cardozo M., Mulder I., van Vugt F., Hermans P.G., van den Bergh S.G., Klazinga W., et al. Aspects of ketogenesis: control and mechanism of ketone-body formation in isolated rat-liver mitochondria. Mol Cell Biochem 1975, 9(3):155-173.
9. Cohn J.N., Levine T.B., Olivari M.T., Garberg V., Lura D., Francis G.S., et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 1984, 311(13):819-823.
10. Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev 1999, 15(6):412-426.
11. Stanley W.C., Recchia F.A., Lopaschuk G.D. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 2005, 85(3):1093-1129.
12. Lommi J., Kupari M., Yki-Jarvinen H. Free fatty acid kinetics and oxidation in congestive heart failure. Am J Cardiol 1998, 81(1):45-50.
13. Marcondes-Braga F.G., Gutz I.G., Batista G.L., Saldiva P.H., Ayub-Ferreira S.M., Issa V.S., et al. Exhaled acetone as a new biomarker of heart failure severity. Chest 2012, 142(2):457-4466.
14. Sharp A.S., Tapp R.J., Thom S.A., Francis D.P., Hughes A.D., Stanton A.V., et al. Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy. Eur Heart J 2010, 31(6):747-752.