Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance

Molecular Nutrition and Food Research

Volumn 56, Issue 12, 2012, Pages 1812-1824

  Metes Kosik, Nicole ^a   Luptak, Ivan ^b   Dibello, Patricia M ^c   Handy, Diane E ^d   Tang, Shiow Shih ^d   Zhi, Hui ^d   Qin, Fuzhong ^b   Jacobsen, Donald W ^c,e   Loscalzo, Joseph ^d   Joseph, Jacob ^a,b,d  

^a VA BOSTON HEALTHCARE SYSTEM   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Collagen; Homocysteine; Methylation; Oxidant Stress; Selenium

Indexed keywords

CYSTEINE; GLUTATHIONE; HOMOCYSTEINE; ISOPROSTANE DERIVATIVE; SELENIUM; SELENOPROTEIN;

ANIMAL; ARTICLE; BLOOD; C57BL MOUSE; CARDIOMYOPATHY; DIET; DIET SUPPLEMENTATION; DNA METHYLATION; DRUG EFFECT; EPIGENETICS; FIBROSIS; GENETICS; HEART MUSCLE; MALE; METABOLISM; MOUSE; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; CARDIOMYOPATHIES; CYSTEINE; DIET; DIETARY SUPPLEMENTS; DNA METHYLATION; EPIGENOMICS; FIBROSIS; GLUTATHIONE; HOMOCYSTEINE; ISOPROSTANES; MALE; MICE; MICE, INBRED C57BL; MYOCARDIUM; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; SELENIUM; SELENOPROTEINS;

MUS;

EID: 84870702010     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200386     Document Type: Article

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