Fall risk increasing drugs and injuries of the frail elderly - evidence from administrative data

Pharmacoepidemiology and Drug Safety

Volumn 21, Issue 12, 2012, Pages 1321-1327

  Bauer, Thomas K ^a,b   Lindenbaum, Katharina ^b   Stroka, Magdalena A ^a,b,c   Engel, Susanne ^c   Linder, Roland ^c   Verheyen, Frank ^c  

^a RWI LEIBNIZ INSTITUTE FOR ECONOMIC RESEARCH   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c Scientific Institute of the TK for Usefulness and Efficiency in Public Health (WINEG)   (Germany)

Author keywords

Count data models; Fall risk increasing drugs; Frail elderly; Multivariate regression; Pharmacoepidemiology; Priscus list

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTIDEPRESSANT AGENT; ANTIHYPERTENSIVE AGENT; ANTIPARKINSON AGENT; ANXIOLYTIC AGENT; HYPNOTIC AGENT; NEUROLEPTIC AGENT; SEDATIVE AGENT;

AGED; ARTICLE; DEPENDENT VARIABLE; FALL RISK; FALL RISK INCREASING DRUG; FEMALE; FRAIL ELDERLY; HUMAN; INDEPENDENT VARIABLE; INJURY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PRESCRIPTION; PRIORITY JOURNAL; PROBABILITY;

ACCIDENTAL FALLS; AGED; FEMALE; FRAIL ELDERLY; HUMANS; INCIDENCE; LOGISTIC MODELS; MALE; RISK; WOUNDS AND INJURIES;

EID: 84870699138     PISSN: 10538569     EISSN: 10991557     Source Type: Journal    
DOI: 10.1002/pds.3357     Document Type: Article

References (28)

1. Burkhardt H, Wehling M. Probleme bei der Pharmakotherapie älterer Patienten. Internist 2010; 51: 737-748.
2. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatr Soc 1999; 47: 30-39.
3. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: II. Cardiac and analgesic drugs. J Am Geriatr Soc 1999; 47: 40-50.
4. Guo Z, Wills P, Viitanen M, Fastbom J, Winblad B. Cognitive Impairment, Drug Use, and the Risk of Hip Fracture in Persons over 75 Years Old: A Community-based Prospective Study. Am J Epidemiol 1998; 148: 887-892.
5. Pierfitte C, Macouillard G, Thicoïpe M, et al. Benzodiazepines and hip fractures in elderly people: case-control study. BMJ 2001; 322: 704-708.
6. Thapa PB, Gideon P, Cost TW, Milam AB, Ray WA. Antidepressants and the Risk of Falls among Nursing Home Residents. N Engl J Med 1998; 339: 875-882.
7. Thapa PB, Gideon P, Fought RL, Ray WA. Psychotropic Drugs and Risk of Recurrent Falls in Ambulatory Nursing Home Residents. Am J Epidemiol 1995; 142: 202-211.
8. Ziere G, Dieleman JP, van der Cammen TJ, Hofman A, Pols HA, Stricker BH. Selective serotonin reuptake inhibiting antidepressants are associated with an increased risk of nonvertebral fractures. J Clin Psychopharmacol 2008; 28: 411-417.
9. Geneletti S, Richardson S, Best N. Adjusting for selection bias in retrospective case-control studies. Biostatistics 2009; 10: 17-31.
10. Katz IR, Rupnow M, Kozma C, Schneider L. Risperidone and Falls in Ambulatory Nursing Home Residents With Dementia and Psychosis or Agitation: Secondary Analysis of a Double-Blind, Placebo-Controlled Trial. Am J Geriatr Psychiatry 2004; 12: 499-508.
11. Lawlor DA, Patel R, Ebrahim S. Association between falls in elderly women and chronic diseases and drug use: cross sectional study. BMJ 2003; 327: 712-717.
12. Kelly KD, Pickett W, Yiannakoulias N, et al. Medication use and falls in community-dwelling older persons. Age Ageing 2003; 32: 503-509.
13. Ensrud KE, Blackwell TL, Mangione CM, et al. Central Nervous System-Active Medications and Risk for Falls in Older Women. Am J Geriatr Psychiatry 2002; 50: 1629-1637.
14. Schwab M, Röder F, Aleker T, et al. Psychotropic drug use, falls and hip fracture in the elderly. Aging (Milano) 2000; 12: 234-239.
15. Gribbin J, Hubbard R, Gladman JRF, Smith C, Lewis S. Risk of falls associated with antihypertensive medication: population-based case-control study. Age Ageing 2010; 39: 592-597.
16. Buckeridge D, Huang A, Hanley J, et al. Risk of Injury Associated with Opioid Use in Older Adults. Am J Geriatr Psychiatry 2010; 58: 1664-1670.
17. Ziere G, Dieleman JP, Hofman A, Pols HA, van der Cammen TJ, Stricker BH. Polypharmacy and falls in the middle age and elderly population. Br J Clin Pharmacol 2006; 61: 218-223.
18. Shuto H, Imakyure O, Matsumoto J, et al. Medication use as a risk factor for inpatient falls in an acute care hospital: a case-crossover study. Br J Clin Pharmacol 2010; 69: 535-542.
19. Statistisches Bundesamt. Pflegestatistik 2009: Pflege im Rahmen der Pflegeversicherung Deutschlandergebnisse (Care Statistics 2009: Care with respect to long-term care insurance, results from Germany), 2011.
20. World Health Organization. Rational Use of Medicines. WHO Drug Information 2006; 20: 261-264.
21. Holt S, Schmiedl S, Thürmann PA. Potenziell inadäquate Medikation für ältere Menschen: Die Priscus-Liste (Potentially inappropriate prescribing in the elderly: The Priscus-list). Deutsches Ärzteblatt International 2010; 107: 543-551.
22. Beers MH. Explicit Criteria for Determining Potentially Inappropriate Medication Use by the Elderly: An Update. Arch Intern Med 1997; 157: 1531-1536.
23. McCullagh P, Nedler JA. Generalized linear models. Chapman and Hall: London, 1997.
24. Khan A, Ullah S, Nitz J. Statistical modelling of falls count data with excess zeros. Inj Prev 2011; 17: 266-270.
25. Sterke CS, van Beeck EF, van der Velde N, et al. New Insights: Dose-Response Relationship Between Psychotropic Drugs and Falls: A Study in Nursing Home Residents With Dementia. J Clin Pharmacol 2012; 52: 947-955.
26. Cameron AC, Trivedi PK. Microeconometrics. Methods and applications. Cambrige Univ. Press: Cambridge, 2009.
27. Sterke CS, Ziere G, van Beeck EF, Looman CWN, van der Cammen TJM. Dose-response relationship between Selective Serotonin Reuptake Inhibitors and Injurious Falls: A study in Nursing Home Residents with Dementia. Br J Clin Pharmacol 2012. 'Accepted Article'. DOI: 10.1111/1365-2125.2012.04124.x.
28. Zaninotto P, Falaschetti E. Comparison of methods for modeling a count outcome with excess zeros: application to Activities of Daily Living (ADL-s). J Epidemiol Community Health 2011; 65: 205-210.