Novel high-viscosity polyacrylamidated chitosan for neural tissue engineering: Fabrication of anisotropic neurodurable scaffold via molecular disposition of persulfate-mediated polymer slicing and complexation

International Journal of Molecular Sciences

Volumn 13, Issue 11, 2012, Pages 13966-13984

  Kumar, Pradeep ^a   Choonara, Yahya E ^a   du Toit, Lisa C ^a   Modi, Girish ^a   Naidoo, Dinesh ^a   Pillay, Viness ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Molecular modeling and simulation; Neural tissue engineering; Neurodurable scaffold; Polyacrylamidated chitosan; Polymer composite; Polymer grafting; Potassium persulphate

Indexed keywords

CHITOSAN; POLYACRYLAMIDE; TISSUE SCAFFOLD; ACRYLIC ACID RESIN; PEROXYDISULFATE POTASSIUM; POLYMER; POTASSIUM DERIVATIVE; SULFATE;

ACTIVE TRANSPORT; ANISOTROPY; ARTICLE; CELL INFILTRATION; CHEMICAL PARAMETERS; CHEMICAL REACTION; CONTROLLED STUDY; GRAFTING EFFICIENCY; GRAFTING RATIO; HYDROGEN BOND; HYDROPHILICITY; HYDROPHOBICITY; IMAGE PROCESSING; MOLECULAR DISPOSITION; MOLECULAR WEIGHT; NANOFABRICATION; NEURAL TISSUE ENGINEERING; NEUROCOMPATIBILITY; POLYMER COMPLEXATION; POLYMER SLICING; POLYMERIZATION; SCANNING ELECTRON MICROSCOPY; SURFACE CHARGE; TISSUE ENGINEERING; TRANSITION TEMPERATURE; VISCOMETRIC AVERAGE MOLECULAR MASS; VISCOSITY; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; NERVE REGENERATION; SYNTHESIS; THERMODYNAMICS; TISSUE SCAFFOLD;

ACRYLIC RESINS; CHITOSAN; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR WEIGHT; NERVE REGENERATION; POLYMERIZATION; POLYMERS; POTASSIUM COMPOUNDS; SULFATES; THERMODYNAMICS; TISSUE ENGINEERING; TISSUE SCAFFOLDS; VISCOSITY;

EID: 84870692104     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms131113966     Document Type: Article

References (38)

1. Kim, I.Y.; Seo, S.J.; Moon, H.S.; Yoo, M.K.; Park, I.Y.; Kim, B.C.; Cho, C.S. Chitosan and its derivatives for tissue engineering applications. Biotechnol. Adv. 2008, 26, 1-21.
2. Van Vlierberghe, S.; Dubruel, P.; Schacht, E. Biopolymer-based hydrogels as scaffold for tissue engineering applications: A review. Biomacromolecules 2011, 12, 1387-1408.
3. Jayakumar, R.; Prabaharan, M.; Reis, R.L.; Mano, J.F. Graft copolymerized chitosan-Present status and applications. Carbohyd. Polym. 2005, 62, 142-158.
4. Alves, N.M.; Mano, J.F. Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications. Int. J. Biol. Macromol. 2008, 43, 401-414.
5. Prabaharan, M. Chitosan derivatives as promising materials for controlled drug delivery. J. Biomater. Appl. 2008, 23, 5-36.
6. Andrade, F.; Goycoolea, F.; Chiappetta, D.A.; das Neves, J.; Sosnik, A.; Sarmento, B. Chitosan-grafted copolymers and chitosan-ligand conjugates as matrices for pulmonary drug delivery. Int. J. Carbohyd. Chem. 2011, doi:10.1155/2011/865704.
7. Zohuriaan-Mehr, M.J. Advances in chitin and chitosan modification through graft copolymerization: A comprehensive review. Iran. Polym. J. 2005, 14, 235-265.
8. Cheng, M.; Gong, K.; Li, J.; Gong, Y.; Zhao, N.; Zhang, X. Surface modification and characterization of chitosan film blended with poly-l-lysine. J. Biomater. Appl. 2004, 19, 59-75.
9. Yang, T.H. Recent applications of polyacrylamide as biomaterials. Recent Patents Mater. Sci. 2008, 1, 29-40.
10. Zhu, Y.; Gao, C.; Guan, J.; Shen, J. Promoting the cytocompatibility of polyurethane scaffold via surface photo-grafting polymerization of acrylamide. J. Mater. Sci. Mater. Med. 2004, 15, 283-289.
11. Kumbar, S.G.; Soppimath, K.S.; Aminabhavi, T.M. Synthesis and characterization of polyacrylamide-grafted chitosan hydrogel microspheres for the controlled release of indomethacin. J. Appl. Polym. Sci. 2003, 87, 1525-1536.
12. Joshi, J.M.; Sinha, V.K. Ceric ammonium nitrate induced grafting of polyacrylamide onto carboxymethyl chitosan. Carbohyd. Polym. 2007, 67, 427-435.
13. Singh, V.; Tiwari, A.; Tripathi, D.N.; Sanghi, R. Microwave enhanced synthesis of chitosan-graftpolyacrylamide. Polymer 2006, 47, 254-260.
14. Singh, V.; Sharma, A.K.; Sanghi, R. Poly(acrylamide) functionalized chitosan: An efficient adsorbent for azo dyes from aqueous solutions. J. Hazard. Mater. 2009, 166, 327-335.
15. Guo, T.Y.; Xia, Y.Q.; Hao, G.J.; Zhang, B.H.; Fu, G.Q.; Yuan, Z.; He, B.L.; Kennedy, J.F. Chemically modified chitosan beads as matrices for adsorptive separation of proteins by molecularly imprinted polymer. Carbohyd. Polym. 2005, 62, 214-221.
16. Li, N.; Bai, R.; Liu, C. Enhanced and selective adsorption of mercury ions on chitosan beads grafted with polyacrylamide via surface-initiated atom transfer radical polymerization. Langmuir 2005, 21, 11780-11787.
17. Fu, G.; Zhao, J.; Yu, H.; Liu, L.; He, B. Bovine serum albumin-imprinted polymer gels prepared by graft copolymerization of acrylamide on chitosan. React. Funct. Polym. 2007, 67, 442-450.
18. Lin, W.J.; Chen, T.D.; Liu, C.W. Synthesis and characterization of lactobionic acid grafted pegylated chitosan and nanoparticle complex application. Polymer 2009, 50, 4166-4174.
19. Lu, B.; Xu, X.D.; Zhang, X.Z.; Cheng, S.X.; Zhuo, R.X. Low molecular mass polyethylenimine grafted n-maleated chitosan for gene delivery: Properties and in vitro transfection studies. Biomacromolecules 2008, 9, 2594-2600.
20. Bonina, P.; Petrova, T.; Manolova, N. pH-Sensitive hydrogels composed of chitosan and polyacrylamide-preparation and properties. J. Bioactive Compat. Polym. 2004, 19, 101-116.
21. Gao, J.; Yu, J.; Wang, W.; Lin, T. The accelerated degradation of aqueous polyacrylamide at low temperature. J. Appl. Polym. Sci. 1998, 69, 791-797.
22. Bawa, P.; Pillay, V.; Choonara, Y.E.; du Toit, L.C.; Ndesendo, V.M.K.; Kumar, P. A composite polyelectrolyte matrix for controlled oral drug delivery. AAPS PharmSciTech 2011, 12, 227-238.
23. Yoksan, R.; Akashi, M.; Miyata, M.; Chirachanchai, S. Optimal γ-ray dose and irradiation conditions for producing low-molecular-weight chitosan that retains its chemical structure. Radiat. Res. 2004, 161, 471-480.
24. Fernandes, L.P.; Morais, W.A.; Santos, A.I.B.; de Arau'jo, A.M.L.; dos Santos, D.E.S.; dos Santos, D.S.; Pavinatto, F.J.; Oliveira, O.N.; Dantas, T.N.C.; Pereira, M.R.; et al. The influence of oxidative degradation on the preparation of chitosan nanoparticles. Colloid Polym. Sci. 2005, 284, 1-9.
25. Lin, K.F.; Hsu, C.Y.; Huang, T.S.; Chiu, W.Y.; Lee, Y.H.; Young, T.H. A novel method to prepare chitosan/montmorillonite nanocomposites. J. Appl. Polym. Sci. 2005, 98, 2042-2047.
26. Kang, H.M.; Cai, Y.L.; Liu, P.S. Synthesis, characterization and thermal sensitivity of chitosan-based graft copolymers. Carbohyd. Polym. 2006, 341, 2851-2857.
27. Yuan, B.; Shang, Y.; Lu, Y.B.; Qin, Z.; Jiang, Y.; Chen, A.; Qian, X.; Wang, G.; Yang, H.; Cheng, R. The flocculating properties of chitosan-graft-polyacrylamide flocculants (i)-effect of the grafting ratio. J. Appl. Polym. Sci. 2010, 117, 1876-1882.
28. Sokker, H.H.; El-Sawy, N.M.; Hassan, M.A.; El-Anadouli, B.E. Adsorption of crude oil from aqueous solution by hydrogel of chitosan-based polyacrylamide prepared by radiation induced graft polymerization. J. Hazard. Mater. 2011, 190, 359-365.
29. Alves, N.M.; Ribelles, J.L.G.; Mano, J.F. Study of the molecular mobility in polymers with the thermally stimulated recovery technique-A review. J. Macromol. Sci. C 2005, 45, 99-124.
30. Sakurai, K.; Maegawa, T.; Takahashi, T. Glass transition temperature of chitosan and miscibility of chitosan/poly(n-vinyl pyrrolidone) blends. Polymer 2004, 41, 7051-7056.
31. Duarte, A.R.C.; Mano, J.F.; Reis, R.L. Novel 3D scaffolds of chitosan-PLLA blends for tissue engineering applications: Preparation and characterization. J. Supercrit. Fluid. 2010, 54, 282-289.
32. Al-Karawi, A.J.M.; Al-Qaisi, Z.H.J.; Abdullah, H.I.; Al-Mokarama, A.M.A.; Al-Heetimi, D.T.A. Synthesis, characterization of acrylamide grafted chitosan and its use in removal of copper(ii) ions from water. Carbohyd. Polym. 2011, 83, 495-500.
33. Merlin, D.L.; Sivasankar, B. Synthesis and characterization of semi-interpenetrating polymer networks using biocompatible polyurethane and acrylamide monomer. Eur. Polym. J. 2009, 45, 165-170.
34. Nori, A.; Yim, E.K.F.; Hen, S.; Leong, K.W. Cell Substrate Interactions. In Principles of Regenerative Medicine; Atala, A., Lanza, R., Thomson, J.A., Nerem, R.M., Eds.; Academic Press: New York, NY, USA, 2010; pp. 666-685.
35. Chung, H.J.; Park, T.G. Surface engineered and drug releasing pre-fabricated scaffold for tissue engineering. Adv. Drug Deliv. Rev. 2007, 59, 249-262.
36. Cao, J.; Tan, Y.; Che, Y.; Xin, H. Novel complex gel beads composed of hydrolyzed polyacrylamide and chitosan: An effective adsorbent for the removal of heavy metal from aqueous solution. Bioresour. Technol. 2010, 101, 2558-2561.
37. Krishnamoorthi, S.; Adhikary, P.; Mal, D.; Singh, R.P. Novel polymeric flocculants based on polyacrylamide grafted dextran in kaolin suspension. J. Appl. Polym. Sci. 2010, 118, 3539-3544.
38. Kumar, P.; Pillay, V.; Choonara, Y.E.; Modi, G.; Naidoo, D.; du Toit, L.C. In silico theoretical molecular modeling for alzheimer's disease: The nicotine-curcumin paradigm in neuroprotection and neurotherapy. Int. J. Mol. Sci. 2011, 12, 694-724.