The effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation in migraine prophylaxis

Biological Trace Element Research

Volumn 150, Issue 1-3, 2012, Pages 42-48

  Tarighat Esfanjani, Ali ^a   Mahdavi, Reza ^a,b   Ebrahimi Mameghani, Mehrangiz ^a   Talebi, Mahnaz ^c   Nikniaz, Zeinab ^a   Safaiyan, Abdolrasool ^a  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

l Carnitine; Magnesium oxide; Migraine; Prophylaxis

Indexed keywords

CARNITINE; MAGNESIUM OXIDE;

ADULT; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG RESPONSE; DRUG WITHDRAWAL; ENZYME ANALYSIS; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIGRAINE; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SUPPLEMENTATION;

ADULT; CARNITINE; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MAGNESIUM; MAGNESIUM OXIDE; MALE; MIGRAINE DISORDERS; RECURRENCE; SEVERITY OF ILLNESS INDEX; SINGLE-BLIND METHOD; SPECTROPHOTOMETRY, ATOMIC; YOUNG ADULT;

EID: 84870688401     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-012-9487-5     Document Type: Article

References (36)

1. Silberstein SD (2004) Migraine. Lancet 363:381-391
2. World Health Organization. 2001. The world health report. Mental health: new understanding, new hope. Geneva: World Health Organization
3. Jensen R, Stover LJ (2008) Epidemiology and comorbidity of headache. Lancet Neurol 7:354-361
4. Geraud G, Lanteri-Mint M, Lucas C, Valade D (2004) French guidelines for the diagnosis and management of migraine in adults and children. Clin Ther 26:305-318
5. Kaniecki R (2004) Headache assessment and management. JAMA 11:1430-1433
6. Lyngberg AC, Rasmussen BK, Jorgensen T, Jensen R (2005) Has the prevalence of migraine and tension type headache changed over a 12-year period? A Danish population survey. Eur J Epidio 20:243-249
7. Ayatollahi SM, Khosravi A (2006) Prevalence of migraine and tension-type headache in primary-school children in Shiraz. East Mediterr Health J 12:809-817
8. Ayatollahi SM, Moradi F, Ayatollahi SA (2002) Prevalence of migraine and tension-type headache in adolescent girls of Shiraz (southern Iran). Headache 42:187-190
9. Gallai V, Sarchielli P, Abbritti G (1993) Red blood cell magnesium levels in migraine patients. Cephalalgia 13:94-98
10. Soriani S, Arnaldi C, De Carlo L, Acudi D, Mazzotta D, Battitella PA, Sartori S, Abbasciano V (1995) Serum and red blood cell magnesium levels in juvenile migraine patients. Headache 35:14-16
11. Gallai V, Sarchielli P, Coata G, Firenze C, Morucci AG (1992) Serum and salivary magnesium levels in migraine. Results in a group of juvenile patients. Headache 32:132-135
12. Welch KM, Ramadan NM (1995) Mitochondria, magnesium and migraine. J Neurol Sci 134:9-14
13. Peikert A, Wilimzig C, Köhne-Volland F (1996) Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia 16:257-263
14. Demirkaya S, Vural O, Dora B, Topcuoglu MA (2001) Efficacy of intravenous magnesium sulphate in the treatment of acute migraine attacks. Headache 41:171-177
15. Wanic-Kossowska M (1997) Protective role of carnitine in acetate metabolism of patients with uremia treated by hemodialysis. Pol Arch Med Wewn 97:534-540
16. Kabbouche MA, Powers SW, Vockell A-LB, LeCates SL, Hershey AD (2002) Carnitine palmityltransferase II (CPT2) deficiency and migraine headache: two case reports. Headache 43:490-495
17. Sparaco M, Feleppa M, Lipton RB, Rapoport AM, Bigal ME (2005) Mitochondrial dysfunction and migraine: evidence and hypotheses. Cephalalgia 26:361-372
18. Montagna P, Cortell P, Barbiroli B (1994) Magnetic resonance spectroscopy studies in migraine. Cephalalgia 14:184-193
19. Lipton RB, Stewart WF (1998) Migraine headaches: epidemiology and comorbidity. Clin Neurosci 5:2-9
20. International Headache Society (1988) Classification and diagnostic criteria for headache disorders, cranial neuralgias, and facial pain. Cephalalgia 8(Suppl 7):1-96
21. Dawson JB, Heaton FW (1961) The determination of magnesium in biological materials by atomic absorption spectrophotometry. Biochem J 80:99-106
22. Roche. 1999. L-Carnitine enzymatic UV test for the determination of L-carnitine in research samples from seminal plasma, serum or urine. Cat. No. 1 242 008
23. Facchinetti F, Sances G, Borella P, Genazzani AR, Nappi G (1991) Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache 31:298-301
24. Taubert K (1994) Magnesium in migraine: results of a multicentre pilot study. Fortschr Med 112:328-330
25. Pfaffenrath V, Wessely P, Meyer C, Isler HR, Evers S, Grotemeyer KH, Taner Z, Soycal D, G'bell H, Fischer M (1996) Magnesium in the prophylaxis of migraine-a double-blind, placebo-controlled study. Cephalalgia 16:436-440
26. Maizels M, Blumenfeld A, Burchette RA (2004) Combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache 44:885-890
27. Mauskop A, Altura BT, Cracco RQ, Altura BM (1995) Intravenous magnesium sulfate relieves acute migraine in patients with low serum ionized magnesium levels: a pilot study. Clin Sci 89:633-636
28. Schoenen J, Sianard-Gainko J, Lenaerts M (1991) Blood magnesium level in migraine. Cephalalgia 11:97-99
29. Sarchielli P, Coata G, Firenze C, Morucci P, Abbritti G, Gallai V (1992) Serum and salivary magnesium levels in migraine and tension-type headache. Results in group of adult patients. Cephalalgia 12:21-27
30. Trauninger A, Pfund Z, Koszegi T, Czopf J (2002) Oral magnesium load test in patients with migraine. Headache 42:114-119
31. Mukherjee S, Bhattacharya G, Mukherajee A (2005) Serum magnesium levels in migraine-clinical and electrophysiological correlations. Poster abstracts 11:S487-S488
32. Okada H, Araga S, Takeshima T, Nakashima K (1998) Plasma lactic acid and pyruvic acid levels in migraine and tension type headache. Headache 38:39-42
33. Knapp AC, Todesco L, Beier K (2008) Toxicity of valproic acid in mice with decreased plasma and tissue carnitine stores. J Pharmacol Exp 324:568-575
34. Uncini A, Lodi R, DiMuzio A, Silvestri G, Servidei S, Lugaresi A, Iotti S, Zaniol P, Barbiroli B (1995) Abnormal brain and muscle energy metabolism shown by 31P-MRS in familial hemiplegic migraine. J Neurol Sci 129:214-222
35. Montagna P, Lodi R, Cortelli P, Pierangeli G, Iotti S, Cevoli S, Zaniol P, Barbiroli B (1997) Phosphorus magnetic resonance spectroscopy in cluster headache. Neurology 48:113-118
36. Lodi R, Iotti S, Cortelli P, Pierangeli G, Cevoli S, Clementi V, Soriani S, Montagna P, Barbiroli B (1997) Deficit of brain and skeletal muscle bioenergetics and low brain magnesium in juvenile migraine: an in vivo 31P magnetic resonance spectroscopy interictal study. Brain Res Bull 42:866-871