-
1
-
-
0037343249
-
Skin cancer is among the most costly of all cancers to treat for the Medicare population
-
DOI 10.1067/mjd.2003.186
-
Housman T, Feldman S, Williford P, Fleischer AJ, Goldman N, Acostamadiedo J, et al. Skin cancer isamong themost costly of all cancers to treat for the Medicare population. J Am Acad Dermatol 2003;48:425-9. (Pubitemid 36337080)
-
(2003)
Journal of the American Academy of Dermatology
, vol.48
, Issue.3
, pp. 425-429
-
-
Housman, T.S.1
Feldman, S.R.2
Williford, P.M.3
Fleischer Jr., A.B.4
Goldman, N.D.5
Acostamadiedo, J.M.6
Chen, G.J.7
-
2
-
-
77955635233
-
Cancer statistics, 2010
-
Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010;60:277-300.
-
(2010)
CA Cancer J Clin
, vol.60
, pp. 277-300
-
-
Jemal, A.1
Siegel, R.2
Xu, J.3
Ward, E.4
-
3
-
-
0037048639
-
Melanoma incidence and mortality among US whites, 1969-1999
-
Geller A, Miller D, Annas G, Demierre M, Gilchrest B, Koh H. Melanoma incidence and mortality among US whites, 1969-1999. JAMA 2002;288:1719-20.
-
(2002)
JAMA
, vol.288
, pp. 1719-1720
-
-
Geller, A.1
Miller, D.2
Annas, G.3
Demierre, M.4
Gilchrest, B.5
Koh, H.6
-
4
-
-
4944242891
-
Polyamines and cancer: Old molecules, new understanding
-
DOI 10.1038/nrc1454
-
Gerner E, Meyskens FL Jr. Polyamines and cancer: old molecules, new understanding. Nat Rev Cancer 2004;4:781-92. (Pubitemid 39331150)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.10
, pp. 781-792
-
-
Gerner, E.W.1
Meyskens Jr., F.L.2
-
5
-
-
0023881236
-
Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy
-
Pegg A. Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy. Cancer Res 1988;48:759-74. (Pubitemid 18061860)
-
(1988)
Cancer Research
, vol.48
, Issue.4
, pp. 759-774
-
-
Pegg, A.E.1
-
6
-
-
0345535621
-
Development of difluoromethylornithine (DFMO) as a chemoprevention agent
-
Meyskens F, Gerner E. Development of difluoromethylornithine (DFMO) as a chemoprevention agent. Clin Cancer Res 1999;5:945-51. (Pubitemid 29233206)
-
(1999)
Clinical Cancer Research
, vol.5
, Issue.5
, pp. 945-951
-
-
Meyskens Jr., F.L.1
Gerner, E.W.2
-
7
-
-
0018408580
-
Induction of mouse epidermal ornithine decarboxylase activity and DNA synthesis by ultraviolet light
-
Verma A, Lowe N, Boutwell R. Induction of mouse epidermal ornithine decarboxylase activity and DNA synthesis by ultraviolet light. Cancer Res 1979;39:1035-40. (Pubitemid 9135130)
-
(1979)
Cancer Research
, vol.39
, Issue.3
, pp. 1035-1040
-
-
Verma, A.K.1
Lowe, N.J.2
Boutwell, R.K.3
-
8
-
-
0018355087
-
Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion
-
Verma A, Shapas B, Rice H, Boutwell R. Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion. Cancer Res 1979;39:419-25. (Pubitemid 9095903)
-
(1979)
Cancer Research
, vol.39
, Issue.2 I
, pp. 419-425
-
-
Verma, A.K.1
Shapas, B.G.2
Rice, H.M.3
Boutwell, R.K.4
-
9
-
-
0021343859
-
Phase I trial and pharmacokinetic studies of α- difluoromethylornithine - An inhibitor of polyamine biosynthesis
-
Abeloff M, Slavik M, Luk G, Griffin C, Hermann J, Blanc O, et al. Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine - an inhibitor of polyamine biosynthesis. J Clin Oncol 1984;2:124-30. (Pubitemid 14152455)
-
(1984)
Journal of Clinical Oncology
, vol.2
, Issue.2
, pp. 124-130
-
-
Abeloff, M.D.1
Slavik, M.2
Luk, G.D.3
-
10
-
-
0022499206
-
Phase II trials of alpha-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer
-
Abeloff MD, Rosen ST, Luk GD, Baylin SB, Zeltzman M, Sjoerdsma A. Phase II trials of alpha-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer. Cancer Treat Rep 1986;70:843-5.
-
(1986)
Cancer Treat Rep
, vol.70
, pp. 843-845
-
-
Abeloff, M.D.1
Rosen, S.T.2
Luk, G.D.3
Baylin, S.B.4
Zeltzman, M.5
Sjoerdsma, A.6
-
11
-
-
0023219533
-
Phase I-II clinical trial with alpha-difluoromethylornithine - An inhibitor of polyamine biosynthesis
-
DOI 10.1016/0277-5379(87)90141-6
-
Horn Y, Schecter PJ, Marton LJ. Phase I-II clinical trial with alpha-difluoromethylornithine - an inhibitor of polyamine biosynthesis. Eur J Cancer Clin Oncol 1987;23:1103-7. (Pubitemid 17112470)
-
(1987)
European Journal of Cancer and Clinical Oncology
, vol.23
, Issue.8
, pp. 1103-1107
-
-
Horn, Y.1
Schechter, P.J.2
Marton, L.J.3
-
12
-
-
0032713928
-
Alpha-difluoromethylornithine as treatment for metastatic breast cancer patients
-
O'Shaughnessy JA, Demers LM, Jones SE, Arseneau J, Khandelwal P, George T, et al. Alpha-difluoromethylornithine as treatment for metastatic breast cancer patients. Clin Cancer Res 1999;5:3438-44.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 3438-3444
-
-
O'Shaughnessy, J.A.1
Demers, L.M.2
Jones, S.E.3
Arseneau, J.4
Khandelwal, P.5
George, T.6
-
13
-
-
0026667443
-
Treatment of recurrent gliomas with eflornithine
-
Levin VA, Prados MD, Yung WK, Gleason MJ, Ictech S, Malec M. Treatment of recurrent gliomas with eflornithine. J Natl Cancer Inst 1992;84:1432-7.
-
(1992)
J Natl Cancer Inst
, vol.84
, pp. 1432-1437
-
-
Levin, V.A.1
Prados, M.D.2
Yung, W.K.3
Gleason, M.J.4
Ictech, S.5
Malec, M.6
-
14
-
-
0033755187
-
Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N′-(2-chloroethyl)-N0- cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme
-
Levin VA, Uhm JH, Jaeckle KA, Choucair A, Flynn PJ, Yung WKA, et al. Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N′-(2-chloroethyl)-N0- cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme. Clin Cancer Res 2000;6:3878-84.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 3878-3884
-
-
Levin, V.A.1
Uhm, J.H.2
Jaeckle, K.A.3
Choucair, A.4
Flynn, P.J.5
Yung, W.K.A.6
-
15
-
-
0035160247
-
Phase III trial of accelerated hyperfractionation with or without difluromethylornithine (DFMO) versus standard fractionated radiotherapy with or without DFMO for newly diagnosed patients with glioblastoma multiforme
-
DOI 10.1016/S0360-3016(00)01458-9, PII S0360301600014589
-
Prados MD, Wara WM, Sneed PK, McDermott M, Chang SM, Rabbitt J, et al. Phase III trial of accelerated hyperfractionation with or without difluromethylornithine (DFMO) versus standard fractionated radiotherapy with or without DFMO for newly diagnosed patients with glioblastoma multiforme. Int J Radiat Oncol Biol Phys 2001;49:71-7. (Pubitemid 32041278)
-
(2001)
International Journal of Radiation Oncology Biology Physics
, vol.49
, Issue.1
, pp. 71-77
-
-
Prados, M.D.1
Wara, W.M.2
Sneed, P.K.3
McDermott, M.4
Chang, S.M.5
Rabbitt, J.6
Page, M.7
Malec, M.8
Davis, R.L.9
Gutin, P.H.10
Lamborn, K.11
Wilson, C.B.12
Phillips, T.L.13
Larson, D.A.14
-
16
-
-
84870691857
-
Neuroblastoma: Ornithine decarboxylase and polyamines are novel targets for therapeutic intervention
-
Bachmann A, Geerts D, Sholler G. Neuroblastoma: ornithine decarboxylase and polyamines are novel targets for therapeutic intervention. Pediatric Cancer 2012;1:91-103.
-
(2012)
Pediatric Cancer
, vol.1
, pp. 91-103
-
-
Bachmann, A.1
Geerts, D.2
Sholler, G.3
-
17
-
-
0027601440
-
Evaluation of alpha-difluoromethylornithine as a potential chemopreventive agent: Tolerance to daily oral administration in humans
-
Creaven PJ, Pendyala L, Petrelli NJ. Evaluation of alpha- difluoromethylornithine as a potential chemopreventive agent: tolerance to daily oral administration in humans. Cancer Epidemiol Biomarkers Prev 1993;2:243-7.
-
(1993)
Cancer Epidemiol Biomarkers Prev
, vol.2
, pp. 243-247
-
-
Creaven, P.J.1
Pendyala, L.2
Petrelli, N.J.3
-
18
-
-
0027266833
-
Randomized phase I chemoprevention dose-seeking study of α- Difluoromethylornithine
-
Love RR, Carbone PP, Verma AK, Gilmore D, Carey P, Tutsch KD, et al. Randomized phase I chemoprevention dose-seeking study of alpha- difluoromethylornithine. J Natl Cancer Inst 1993;85:732-7. (Pubitemid 23133595)
-
(1993)
Journal of the National Cancer Institute
, vol.85
, Issue.9
, pp. 732-737
-
-
Love, R.R.1
Carbone, P.P.2
Verma, A.K.3
Gilmore, D.4
Carey, P.5
Tutsch, K.D.6
Pomplun, M.7
Wilding, G.8
-
19
-
-
0036794934
-
A phase II breast cancer chemoprevention trial of oral α-difluoromethylornithine: Breast tissue, imaging, and serum and urine biomarkers
-
Fabian CJ, Kimler BF, Brady DA, Mayo MS, Chang CH, Ferraro JA, et al. A phase II breast cancer chemoprevention trial of oral alpha- difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers. Clin Cancer Res 2002;8:3105-17. (Pubitemid 35155020)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.10
, pp. 3105-3117
-
-
Fabian, C.J.1
Kimler, B.F.2
Brady, D.A.3
Mayo, M.S.4
Chang, C.H.J.5
Ferraro, J.A.6
Zalles, C.M.7
Stanton, A.L.8
Masood, S.9
Grizzle, W.E.10
Boyd, N.F.11
Arneson, D.W.12
Johnson, K.A.13
-
20
-
-
11344295619
-
Results of a phase II double-blinded randomized clinical trial of difluoromethylornithine for cervical intraepithelial neoplasia grades 2 to 3
-
Vlastos AT, West LA, Atkinson EN, Boiko I, Malpica A, Hong WK, et al. Results of a phase II double-blinded randomized clinical trial of difluoromethylornithine for cervical intraepithelial neoplasia grades 2 to 3. Clin Cancer Res 2005;11:390-6. (Pubitemid 40075819)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.1
, pp. 390-396
-
-
Vlastos, A.-T.1
West, L.A.2
Atkinson, E.N.3
Boiko, I.4
Malpica, A.5
Hong, W.K.6
Follen, M.7
-
21
-
-
33745463143
-
Randomized Prospective Phase III Trial of Difluoromethylornithine vs Placebo in Preventing Recurrence of Completely Resected Low Risk Superficial Bladder Cancer
-
DOI 10.1016/j.juro.2006.03.061, PII S0022534706008305
-
Messing E, Kim KM, Sharkey F, Schultz M, Parnes H, Kim D, et al. Randomized prospective phase III trial of difluoromethylornithine vs placebo in preventing recurrence of completely resected low risk superficial bladder cancer. J Urol 2006;176:500-4. (Pubitemid 43949406)
-
(2006)
Journal of Urology
, vol.176
, Issue.2
, pp. 500-504
-
-
Messing, E.1
Kim, K.M.2
Sharkey, F.3
Schultz, M.4
Parnes, H.5
Kim, D.6
Saltzstein, D.7
Wilding, G.8
-
22
-
-
39449086676
-
The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: Results of a year-long phase IIb randomized placebo-controlled chemoprevention trial
-
DOI 10.1158/1055-9965.EPI-07-0658
-
Simoneau AR, Gerner EW, Nagle R, Ziogas A, Fujikawa-Brooks S, Yerushalmi H, et al. The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial. Cancer Epidemiol Biomarkers Prev 2008;17:292-9. (Pubitemid 351272778)
-
(2008)
Cancer Epidemiology Biomarkers and Prevention
, vol.17
, Issue.2
, pp. 292-299
-
-
Simoneau, A.R.1
Gerner, E.W.2
Nagle, R.3
Ziogas, A.4
Fujikawa-Brooks, S.5
Yerushalmi, H.6
Ahlering, T.E.7
Lieberman, R.8
McLaren, C.E.9
Anton-Culver, H.10
Meyskens Jr., F.L.11
-
23
-
-
0042098091
-
Effect of α-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention
-
Meyskens FL Jr, Gerner E, Emerson S, Pelot D, Durbin T, Doyle K, et al. Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention. J Natl Cancer Inst 1998;90:1212-8. (Pubitemid 28407087)
-
(1998)
Journal of the National Cancer Institute
, vol.90
, Issue.16
, pp. 1212-1218
-
-
Meyskens Jr., F.L.1
Gerner, E.W.2
Emerson, S.3
Pelot, D.4
Durbin, T.5
Doyle, K.6
Lagerberg, W.7
-
24
-
-
0034905908
-
Phase I chemoprevention study of difluoromethylornithine in subjects with organ transplants
-
Carbone PP, Pirsch JD, Thomas JP, Douglas JA, Verma AK, Larson PO, et al. Phase I chemoprevention study of difluoromethylornithine in subjects with organ transplants. Cancer Epidemiol Biomarkers Prev 2001;10:657-61. (Pubitemid 32703200)
-
(2001)
Cancer Epidemiology Biomarkers and Prevention
, vol.10
, Issue.6
, pp. 657-661
-
-
Carbone, P.P.1
Pirsch, J.D.2
Thomas, J.P.3
Douglas, J.A.4
Verma, A.K.5
Larson, P.O.6
Snow, S.7
Tutsch, K.D.8
Pauk, D.9
-
25
-
-
55549132996
-
Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: A randomized placebo-controlled, double-blind trial
-
Meyskens FL Jr, McLaren CE, Pelot D, Fujikawa-Brooks S, Carpenter PM, Hawk E, et al. Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev Res 2008;1:32-8.
-
(2008)
Cancer Prev Res
, vol.1
, pp. 32-38
-
-
Meyskens Jr., F.L.1
McLaren, C.E.2
Pelot, D.3
Fujikawa-Brooks, S.4
Carpenter, P.M.5
Hawk, E.6
-
26
-
-
79957810567
-
Evaluation of difluoromethylornithine for the chemoprevention of Barrett's esophagus and mucosal dysplasia
-
Sinicrope F, Broaddus R, Joshi N, Gerner E, Half E, Kirsch I, et al. Evaluation of difluoromethylornithine for the chemoprevention of Barrett's esophagus and mucosal dysplasia. Cancer Prev Res 2011;4:829.
-
(2011)
Cancer Prev Res
, vol.4
, pp. 829
-
-
Sinicrope, F.1
Broaddus, R.2
Joshi, N.3
Gerner, E.4
Half, E.5
Kirsch, I.6
-
27
-
-
0034523080
-
Chemoprevention of human actinic keratoses by topical 2-(Difluoromethyl)-dl-ornithine
-
Alberts DS, Dorr RT, Einspahr JG, Aickin M, Saboda K, Xu MJ, et al. Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl- ornithine. Cancer Epidemiol Biomarkers Prev 2000;9:1281-6. (Pubitemid 32044795)
-
(2000)
Cancer Epidemiology Biomarkers and Prevention
, vol.9
, Issue.12
, pp. 1281-1286
-
-
Alberts, D.S.1
Dorr, R.T.2
Einspahr, J.G.3
Aickin, M.4
Saboda, K.5
Xu, M.J.6
Peng, Y.-M.7
Goldman, R.8
Foote, J.A.9
Warneke, J.A.10
Salasche, S.11
Roe, D.J.12
Bowden, G.T.13
-
28
-
-
0036156755
-
Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer
-
Einspahr JG, Nelson M, Saboda K, Warneke J, Bowden GT, Alberts DS. Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer. Clin Cancer Res 2002;8:149-55. (Pubitemid 34101471)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.1
, pp. 149-155
-
-
Einspahr, J.G.1
Nelson, M.A.2
Saboda, K.3
Warneke, J.4
Bowden, G.T.5
Alberts, D.S.6
-
29
-
-
74549196323
-
Chemopreventive efficacy of topical difluoromethylornithine and/or triamcinolone in the treatment of actinic keratoses analyzed by karyometry
-
Bartels P, Yozwiak M, Einspahr J, Saboda K, Liu Y, Brooks C, et al. Chemopreventive efficacy of topical difluoromethylornithine and/or triamcinolone in the treatment of actinic keratoses analyzed by karyometry. Anal Quant Cytol Histol 2009;31:355-66.
-
(2009)
Anal Quant Cytol Histol
, vol.31
, pp. 355-366
-
-
Bartels, P.1
Yozwiak, M.2
Einspahr, J.3
Saboda, K.4
Liu, Y.5
Brooks, C.6
-
30
-
-
77649195334
-
A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer
-
Bailey HH, Kim K, Verma AK, Sielaff K, Larson PO, Snow S, et al. A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer. Cancer Prev Res 2010;3:35-47.
-
(2010)
Cancer Prev Res
, vol.3
, pp. 35-47
-
-
Bailey, H.H.1
Kim, K.2
Verma, A.K.3
Sielaff, K.4
Larson, P.O.5
Snow, S.6
-
31
-
-
84870662091
-
A phase III skin cancer chemoprevention study of DFMO: Long-term follow-up of skin cancer events and toxicity
-
Kreul S, Havighurst T, Kim K, Mendonca E, Wood G, Snow S, et al. A phase III skin cancer chemoprevention study of DFMO: long-term follow-up of skin cancer events and toxicity. Cancer Prev Res 2012;5:1368-74.
-
(2012)
Cancer Prev Res
, vol.5
, pp. 1368-1374
-
-
Kreul, S.1
Havighurst, T.2
Kim, K.3
Mendonca, E.4
Wood, G.5
Snow, S.6
-
32
-
-
0037464769
-
Overview of the main outcomes in breast-cancer prevention trials
-
Cuzick J, Powles T, Veronesi U, Forbes J, Edwards R, Ashley S, et al. Overview of the main outcomes in breast-cancer prevention trials. Lancet 2003;361:296.
-
(2003)
Lancet
, vol.361
, pp. 296
-
-
Cuzick, J.1
Powles, T.2
Veronesi, U.3
Forbes, J.4
Edwards, R.5
Ashley, S.6
-
33
-
-
33847793068
-
Long-term results of tamoxifen prophylaxis for breast cancer-96-month follow-up of the randomized IBIS-I trial
-
DOI 10.1093/jnci/djk049
-
Cuzick J, Forbes JF, Sestak I, Cawthorn S, Hamed H, Holli K, et al. Long-term results of tamoxifen prophylaxis for breast cancer-96-month follow-up of the randomized IBIS-I trial. J Natl Cancer Inst 2007;99:272-82. (Pubitemid 47073490)
-
(2007)
Journal of the National Cancer Institute
, vol.99
, Issue.4
, pp. 272-282
-
-
Cuzick, J.1
Forbes, J.F.2
Sestak, I.3
Cawthorn, S.4
Hamed, H.5
Holli, K.6
Howell, A.7
-
34
-
-
0023911552
-
Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin
-
Kraemer K, DiGiovanna J, Moshell A, Tarone R, Peck G. Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin. N Engl J Med 1988;318:1633.
-
(1988)
N Engl J Med
, vol.318
, pp. 1633
-
-
Kraemer, K.1
DiGiovanna, J.2
Moshell, A.3
Tarone, R.4
Peck, G.5
-
35
-
-
33745249570
-
Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial
-
Vogel V, Costantino J, Wickerham D, Cronin W, Cecchini R, Atkins J, et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial. JAMA 2006;295:2727-41.
-
(2006)
JAMA
, vol.295
, pp. 2727-2741
-
-
Vogel, V.1
Costantino, J.2
Wickerham, D.3
Cronin, W.4
Cecchini, R.5
Atkins, J.6
-
36
-
-
19744380776
-
Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial
-
Bresalier R, Sandler R, Quan H, Bolognese J, Oxenius B, Horgan K, et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 2005;352:1092.
-
(2005)
N Engl J Med
, vol.352
, pp. 1092
-
-
Bresalier, R.1
Sandler, R.2
Quan, H.3
Bolognese, J.4
Oxenius, B.5
Horgan, K.6
|