Dynamic Control of Selectivity in the Ubiquitination Pathway Revealed by an ASP to GLU Substitution in an Intra-Molecular Salt-Bridge Network

PLoS Computational Biology

Volumn 8, Issue 11, 2012, Pages

  van Wijk, Sjoerd J L ^a,c   Melquiond, Adrien S J ^b   de Vries, Sjoerd J ^b,d   Timmers, H Th Marc ^a   Bonvin, Alexandre M J J ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DYNAMICS; ENZYMES; PLANTS (BOTANY);

ASPARTATES; BRIDGE NETWORKS; DYNAMIC CONTROLS; DYNAMICS SIMULATION; MOLECULAR SALTS; SALT BRIDGES; SEQUENCE STRUCTURE; SPECIFIC INTERACTION; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITINATION;

MOLECULAR DYNAMICS;

ASPARTIC ACID; GLUTAMIC ACID; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE E3;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONTROLLED STUDY; MOLECULAR DYNAMICS; MOLECULAR MODEL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; UBIQUITINATION;

EID: 84870667444     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002754     Document Type: Article

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