AMG 386 in combination with sorafenib in patients with metastatic clear cell carcinoma of the kidney: A randomized, double-blind, placebo-controlled, phase 2 study

Cancer

Volumn 118, Issue 24, 2012, Pages 6152-6161

  Rini, Brian ^a   Szczylik, Cezary ^b   Tannir, Nizar M ^c   Koralewski, Piotr ^d   Tomczak, Piotr ^e   Deptala, Andrzej ^f   Dirix, Luc Y ^g   Fishman, Mayer ^h   Ramlau, Rodryg ⁱ   Ravaud, Alain ^j   Rogowski, Wojciech ^k   Kracht, Karolyn ^l   Sun, Yu Nien ^l   Bass, Michael B ^l   Puhlmann, Markus ^l   Escudier, Bernard ^m  

^a TAUSSIG CANCER INSTITUTE   (United States)

^b MILITARY INSTITUTE OF MEDICINE   (Poland)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d Szpital Specjalistyczny Ludwika Rydygiera   (Poland)

^e Ginekologiczno Po o niczy Szpital Kliniczny im Heliodora wi cickiego Uniwersytetu Medycznego im Karola Marcinkowskiego   (Poland)

^f MEDICAL UNIVERSITY OF WARSAW   (Poland)

^g SINT AUGUSTINUS HOSPITAL   (Belgium)

^h H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

ⁱ POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^j BORDEAUX UNIVERSITY HOSPITAL   (France)

^k ZOZ MSWiA   (Poland)

^l AMGEN INC   (United States)

^m INSTITUT GUSTAVE ROUSSY   (France)

more..

Author keywords

AMG 386; clear cell renal cell carcinoma; phase 2 clinical trial; randomized controlled trial; sorafenib

Indexed keywords

PLACEBO; SORAFENIB; TREBANANIB;

ABDOMINAL PAIN; ADULT; AGED; ALOPECIA; ANTINEOPLASTIC ACTIVITY; ANUS FISTULA; ARTERIAL THROMBOEMBOLISM; ARTICLE; BLEEDING; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER SURVIVAL; CONTROLLED STUDY; DIARRHEA; DIGESTIVE SYSTEM PERFORATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG FATALITY; DRUG FEVER; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; HAND FOOT SYNDROME; HEART INFARCTION; HUMAN; HYPERTENSION; INSOMNIA; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS POTENTIAL; MUCOSA INFLAMMATION; NAUSEA; OROPHARYNX PAIN; OUTCOME ASSESSMENT; PERIANAL ABSCESS; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE; SURVIVAL TIME; UPPER ABDOMINAL PAIN; VENOUS THROMBOEMBOLISM; WOUND HEALING IMPAIRMENT;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BENZENESULFONATES; CARCINOMA, RENAL CELL; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; HUMANS; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PYRIDINES; RECOMBINANT FUSION PROTEINS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 84870659220     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.27632     Document Type: Article

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