Wnt5a promotes ewing sarcoma cell migration through upregulating CXCR4 expression

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Jin, Zhe ^a   Zhao, Chenghai ^a   Han, Xiaorui ^a   Han, Yaxin ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; MESSENGER RNA; PLASMID DNA; PROTEIN C JUN; PROTEIN KINASE C; RECOMBINANT PROTEIN; SECRETED FRIZZLED RELATED PROTEIN 1; SECRETED FRIZZLED RELATED PROTEIN 2; SECRETED FRIZZLED RELATED PROTEIN 5; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE; WNT5A PROTEIN;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL MIGRATION; CLINICAL ARTICLE; CONTROLLED STUDY; EWING SARCOMA; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; METASTASIS; POLYMERASE CHAIN REACTION; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANTHRACENES; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL MOVEMENT; DNA METHYLATION; ENZYME INHIBITORS; EYE PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALEIMIDES; MEMBRANE PROTEINS; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS; RECEPTORS, CXCR4; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SARCOMA, EWING; UP-REGULATION; WNT PROTEINS;

EID: 84870656223     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-480     Document Type: Article

References (21)

1. Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, Trent JM. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 2002, 1(3):279-288. 10.1016/S1535-6108(02)00045-4, 12086864.
2. Enomoto M, Hayakawa S, Itsukushima S, Ren DY, Matsuo M, Tamada K, Oneyama C, Okada M, Takumi T, Nishita M, Minami Y. Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling. Oncogene 2009, 28(36):3197-3208. 10.1038/onc.2009.175, 19561643.
3. Schwartz AL, Malgor R, Dickerson E, Weeraratna AT, Slominski A, Wortsman J, Harii N, Kohn AD, Moon RT, Schwartz FL, Goetz DJ, Kohn LD, McCall KD. Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin Cancer Res 2009, 15(12):4114-4122. 10.1158/1078-0432.CCR-09-0005, 2765042, 19470740.
4. Yamamoto H, Oue N, Sato A, Hasegawa Y, Yamamoto H, Matsubara A, Yasui W, Kikuchi A. Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase. Oncogene 2010, 29(14):2036-2046. 10.1038/onc.2009.496, 20101234.
5. Liang H, Chen Q, Coles AH, Anderson SJ, Pihan G, Bradley A, Gerstein R, Jurecic R, Jones SN. Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell 2003, 4(5):349-360. 10.1016/S1535-6108(03)00268-X, 14667502.
6. Kremenevskaja N, von Wasielewski R, Rao AS, Schöfl C, Andersson T, Brabant G. Wnt-5a has tumor suppressor activity in thyroid carcinoma. Oncogene 2005, 24(13):2144-2154. 10.1038/sj.onc.1208370, 15735754.
7. Uren A, Wolf V, Sun YF, Azari A, Rubin JS, Toretsky JA. Wnt/Frizzled signaling in Ewing sarcoma. Pediatr Blood Cancer 2004, 43(3):243-249. 10.1002/pbc.20124, 15266408.
8. Veeck J, Geisler C, Noetzel E, Alkaya S, Hartmann A, Knüchel R, Dahl E. Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. Carcinogenesis 2008, 29(5):991-998. 10.1093/carcin/bgn076, 18356147.
9. Zhao C, Bu X, Zhang N, Wang W. Downregulation of SFRP5 expression and its inverse correlation with those of MMP-7 and MT1-MMP in gastric cancer. BMC Cancer 2009, 9:224. 10.1186/1471-2407-9-224, 2714159, 19586554.
10. Su HY, Lai HC, Lin YW, Liu CY, Chen CK, Chou YC, Lin SP, Lin WC, Lee HY, Yu MH. Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway. Int J Cancer 2010, 127(3):555-567. 10.1002/ijc.25083, 19957335.
11. Ouchi N, Higuchi A, Ohashi K, Oshima Y, Gokce N, Shibata R, Akasaki Y, Shimono A, Walsh K. Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 2010, 329(5990):454-457. 10.1126/science.1188280, 3132938, 20558665.
12. Bennani-Baiti IM, Cooper A, Lawlor ER, Kauer M, Ban J, Aryee DN, Kovar H. Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing's sarcoma. Clin Cancer Res 2010, 16(14):3769-3778. 10.1158/1078-0432.CCR-10-0558, 2905506, 20525755.
13. Zhao C, Lu X, Bu X, Zhang N, Wang W. Involvement of tumor necrosis factor-alpha in the upregulation of CXCR4 expression in gastric cancer induced by Helicobacter pylori. BMC Cancer 2010, 10:419. 10.1186/1471-2407-10-419, 3087324, 20699000.
14. Zou H, Molina JR, Harrington JJ, Osborn NK, Klatt KK, Romero Y, Burgart LJ, Ahlquist DA. Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett's esophagus. Int J Cancer 2005, 116(4):584-591. 10.1002/ijc.21045, 15825175.
15. Schleiermacher G, Peter M, Oberlin O, Philip T, Rubie H, Mechinaud F, Sommelet-Olive D, Landman-Parker J, Bours D, Michon J, Delattre O, . Société Française d'Oncologie Pédiatrique Increased risk of systemic relapses associated with bone marrow micrometastasis and circulating tumor cells in localized ewing tumor. J Clin Oncol 2003, 21(1):85-91. 10.1200/JCO.2003.03.006, 12506175, Société Française d'Oncologie Pédiatrique.
16. Kamura S, Matsumoto Y, Fukushi JI, Fujiwara T, Iida K, Okada Y, Iwamoto Y. Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumors by activating the FGFR1-PI3K-Rac1 pathway. Br J Cancer 2010, 103(3):370-381. 10.1038/sj.bjc.6605775, 2920026, 20606682.
17. Meynet O, Scotlandi K, Pradelli E, Manara MC, Colombo MP, Schmid-Antomarchi H, Picci P, Bernard A, Bernard G. Xg expression in Ewing's sarcoma is of prognostic value and contributes to tumor invasiveness. Cancer Res 2010, 70(9):3730-3738. 10.1158/0008-5472.CAN-09-2837, 20388798.
18. Sáinz-Jaspeado M, Lagares-Tena L, Lasheras J, Navid F, Rodriguez-Galindo C, Mateo-Lozano S, Notario V, Sanjuan X, Garcia Del Muro X, Fabra A, Tirado OM. Caveolin-1 modulates the ability of Ewing's sarcoma to metastasize. Mol Cancer Res 2010, 8(11):1489-1500. 10.1158/1541-7786.MCR-10-0060, 21106507.
19. Emeche CD, French AD, O'Connell MP, Xu M, Weeraratna AT, Taub DD. Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migration. Blood 2009, 114(7):1366-1373. 10.1182/blood-2008-08-175869, 2727408, 19520808.
20. Dissanayake SK, Wade M, Johnson CE, O'Connell MP, Leotlela PD, French AD, Shah KV, Hewitt KJ, Rosenthal DT, Indig FE, Jiang Y, Nickoloff BJ, Taub DD, Trent JM, Moon RT, Bittner M, Weeraratna AT. The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem 2007, 282(23):17259-17271. 10.1074/jbc.M700075200, 2263117, 17426020.
21. Yamamoto H, Kitadai Y, Yamamoto H, Oue N, Ohdan H, Yasui W, Kikuchi A. Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells. Gastroenterology 2009, 137(1):242-252. 252.e1-6, 10.1053/j.gastro.2009.02.003, 19582886.