Meiotic DSBs and the control of mammalian recombination

Cell Research

Volumn 22, Issue 12, 2012, Pages 1624-1626

  Paigen, Kenneth ^a   Petkov, Petko ^a  

^a JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; MEIOTIC RECOMBINATION PROTEIN SPO11; PRDM9 PROTEIN, MOUSE;

ANIMAL; ARTICLE; CHROMATID; DOUBLE STRANDED DNA BREAK; GENETIC RECOMBINATION; GENETICS; MALE; MEIOSIS; METABOLISM; MOUSE; MOUSE MUTANT;

ANIMALS; CHROMATIDS; DNA BREAKS, DOUBLE-STRANDED; ENDODEOXYRIBONUCLEASES; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; MALE; MEIOSIS; MICE; MICE, KNOCKOUT; RECOMBINATION, GENETIC;

MAMMALIA; MUS;

EID: 84870611494     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2012.109     Document Type: Article

References (17)

1. Walker MB, King BL, Paigen K. Clusters of ancestrally related genes that show paralogy in whole or in part are a major feature of the genomes of humans and other species. PLoS One 2012; 7:e35274.
2. Steinmetz M, Minard K, Horvath S, et al. A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature 1982; 300:35-42. (Pubitemid 12005050)
3. McVean GA, Myers SR, Hunt S, Deloukas P, Bentley DR, Donnelly P. The fine-scale structure of recombination rate variation in the human genome. Science 2004; 304:581-584. (Pubitemid 38541915)
4. Paigen K, Szatkiewicz JP, Sawyer K, et al. The recombinational anatomy of a mouse chromosome. PLoS Genet 2008; 4:e1000119.
5. Myers S, Bowden R, Tumian A, et al. Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination. Science 2010; 327:876-879.
6. Baudat F, Buard J, Grey C, et al. PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Science 2010; 327:836-840.
7. Parvanov ED, Petkov PM, Paigen K. Prdm9 controls activation of mammalian recombination hotspots. Science 2010; 327:835.
8. Hayashi K, Yoshida K, Matsui Y. A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Nature 2005; 438:374-378. (Pubitemid 41643955)
9. Smagulova F, Gregoretti IV, Brick K, Khil P, Camerini-Otero RD, Petukhova GV. Genome-wide analysis reveals novel molecular features of mouse recombination hotspots. Nature 2011; 472:375-378.
10. Khil PP, Smagulova F, Brick KM, Camerini-Otero RD, Petukhova GV. Sensitive mapping of recombination hotspots using sequencing-based detection of ssDNA. Genome Res 2012; 22:957-965.
11. Brick K, Smagulova F, Khil P, Camerini-Otero RD, Petukhova GV. Genetic recombination is directed away from functional genomic elements in mice. Nature 2012; 485:642-645.
12. Muñoz-Fuentes V, Di Rienzo A, Vilà C. Prdm9, a major determinant of meiotic recombination hotspots, is not functional in dogs and their wild relatives, wolves and coyotes. PLoS One 2011; 6:e25498.
13. Axelsson E, Webster MT, Ratnakumar A, LUPA Consortium, Ponting CP, Lindblad-Toh K. Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome. Genome Res 2012; 22:51-63.
14. Boulton A, Myers RS, Redfield RJ. The hotspot conversion paradox and the evolution of meiotic recombination. Proc Natl Acad Sci USA 1997; 94:8058-8063. (Pubitemid 27343776)
15. Thomas JH, Emerson RO, Shendure J. Extraordinary molecular evolution in the PRDM9 fertility gene. PLoS One 2009; 4:e8505.
16. Oliver PL, Goodstadt L, Bayes JJ, et al. Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa. PLoS Genet 2009; 5:e1000753.
17. Mihola O, Trachtulec Z, Vlcek C, Schimenti JC, Forejt J. A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science 2009; 323:373-375.