Increased Prevalence of Anellovirus in Pediatric Patients with Fever

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  McElvania TeKippe, Erin ^a   Wylie, Kristine M ^a   Deych, Elena ^a   Sodergren, Erica ^a   Weinstock, George ^a   Storch, Gregory A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; ANELLOVIRUS; ARTICLE; BODY TEMPERATURE; CHILD; CONTROLLED STUDY; FEMALE; FEVER; HUMAN; HUMAN TISSUE; INFANT; MALE; NASOPHARYNX; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; RACE DIFFERENCE; SEROPREVALENCE; SEX DIFFERENCE; TORQUE TENO LIKE MIDI VIRUS; TORQUE TENO LIKE MINI VIRUS; TORQUE TENO VIRUS; VIRUS DETECTION;

ANELLOVIRUS; BODY TEMPERATURE; CHILD; CHILD, PRESCHOOL; CONTINENTAL POPULATION GROUPS; DNA VIRUS INFECTIONS; DNA, VIRAL; FEMALE; FEVER; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INFANT; MALE; MISSOURI; POLYMERASE CHAIN REACTION; PREVALENCE; SPECIES SPECIFICITY;

ANELLOVIRUS; DNA VIRUSES; NON-A, NON-B HEPATITIS VIRUS; TORQUE TENO VIRUS; TTV-LIKE MINI VIRUS;

EID: 84870610915     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050937     Document Type: Article

References (54)

1. Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, et al. (1997) A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun 241: 92-97.
2. Okamoto H, Akahane Y, Ukita M, Fukuda M, Tsuda F, et al. (1998) Fecal excretion of a nonenveloped DNA virus (TTV) associated with posttransfusion non-A-G hepatitis. J Med Virol 56: 128-132.
3. Takahashi K, Iwasa Y, Hijikata M, Mishiro S, (2000) Identification of a new human DNA virus (TTV-like mini virus, TLMV) intermediately related to TT virus and chicken anemia virus. Arch Virol 145: 979-993.
4. Ninomiya M, Nishizawa T, Takahashi M, Lorenzo FR, Shimosegawa T, et al. (2007) Identification and genomic characterization of a novel human torque teno virus of 3.2 kb. J Gen Virol 88: 1939-1944.
5. (2011) Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses.; King AM, Lefkowitz E, Adams MJ, Carstens EB, editors.
6. Gimenez-Barcons M, Forns X, Ampurdanes S, Guilera M, Soler M, et al. (1999) Infection with a novel human DNA virus (TTV) has no pathogenic significance in patients with liver diseases. J Hepatol 30: 1028-1034.
7. Naoumov NV, Petrova EP, Thomas MG, Williams R, (1998) Presence of a newly described human DNA virus (TTV) in patients with liver disease. Lancet 352: 195-197.
8. Kanda T, Yokosuka O, Ikeuchi T, Seta T, Kawai S, et al. (1999) The role of TT virus infection in acute viral hepatitis. Hepatology 29: 1905-1908.
9. Maggi F, Pifferi M, Fornai C, Andreoli E, Tempestini E, et al. (2003) TT virus in the nasal secretions of children with acute respiratory diseases: relations to viremia and disease severity. J Virol 77: 2418-2425.
10. Chung JY, Han TH, Koo JW, Kim SW, Seo JK, et al. (2007) Small anellovirus infections in Korean children. Emerg Infect Dis 13: 791-793.
11. Maggi F, Pifferi M, Tempestini E, Lanini L, De Marco E, et al. (2004) Correlation between Torque tenovirus infection and serum levels of eosinophil cationic protein in children hospitalized for acute respiratory diseases. J Infect Dis 190: 971-974.
12. Maggi F, Bendinelli M, (2010) Human anelloviruses and the central nervous system. Rev Med Virol 20: 392-407.
13. Biagini P, Gallian P, Attoui H, Cantaloube JF, Touinssi M, et al. (2001) Comparison of systems performance for TT virus detection using PCR primer sets located in non-coding and coding regions of the viral genome. J Clin Virol 22: 91-99.
14. Khudyakov YE, Cong ME, Nichols B, Reed D, Dou XG, et al. (2000) Sequence heterogeneity of TT virus and closely related viruses. J Virol 74: 2990-3000.
15. Okamoto H NT, Takahashi M (2004) Torque teno virus (TTV): molecular virology and clinical implications. In: IK M, editor. Viral hepatitis:molecular biology, diagnosis, epidemiology and control. Amsterdam: Elsevier.
16. Peng YH, Nishizawa T, Takahashi M, Ishikawa T, Yoshikawa A, et al. (2002) Analysis of the entire genomes of thirteen TT virus variants classifiable into the fourth and fifth genetic groups, isolated from viremic infants. Arch Virol 147: 21-41.
17. Thom K, Morrison C, Lewis JC, Simmonds P, (2003) Distribution of TT virus (TTV), TTV-like minivirus, and related viruses in humans and nonhuman primates. Virology 306: 324-333.
18. Biagini P, Uch R, Belhouchet M, Attoui H, Cantaloube JF, et al. (2007) Circular genomes related to anelloviruses identified in human and animal samples by using a combined rolling-circle amplification/sequence-independent single primer amplification approach. J Gen Virol 88: 2696-2701.
19. Okamoto H, Nishizawa T, Tawara A, Peng Y, Takahashi M, et al. (2000) Species-specific TT viruses in humans and nonhuman primates and their phylogenetic relatedness. Virology 277: 368-378.
20. Ninomiya M, Takahashi M, Shimosegawa T, Okamoto H, (2007) Analysis of the entire genomes of fifteen torque teno midi virus variants classifiable into a third group of genus Anellovirus. Arch Virol 152: 1961-1975.
21. Simmonds P, (2002) TT virus infection: a novel virus-host relationship. J Med Microbiol 51: 455-458.
22. Kamada K, Kuroishi A, Kamahora T, Kabat P, Yamaguchi S, et al. (2006) Spliced mRNAs detected during the life cycle of Chicken anemia virus. J Gen Virol 87: 2227-2233.
23. Miyata H, Tsunoda H, Kazi A, Yamada A, Khan MA, et al. (1999) Identification of a novel GC-rich 113-nucleotide region to complete the circular, single-stranded DNA genome of TT virus, the first human circovirus. J Virol 73: 3582-3586.
24. Mushahwar IK, Erker JC, Muerhoff AS, Leary TP, Simons JN, et al. (1999) Molecular and biophysical characterization of TT virus: evidence for a new virus family infecting humans. Proc Natl Acad Sci U S A 96: 3177-3182.
25. Biagini P, Gallian P, Attoui H, Touinssi M, Cantaloube J, et al. (2001) Genetic analysis of full-length genomes and subgenomic sequences of TT virus-like mini virus human isolates. J Gen Virol 82: 379-383.
26. Crowther RA, Berriman JA, Curran WL, Allan GM, Todd D, (2003) Comparison of the structures of three circoviruses: chicken anemia virus, porcine circovirus type 2, and beak and feather disease virus. J Virol 77: 13036-13041.
27. Peters MA, Jackson DC, Crabb BS, Browning GF, (2002) Chicken anemia virus VP2 is a novel dual specificity protein phosphatase. J Biol Chem 277: 39566-39573.
28. Okamoto H, (2009) History of discoveries and pathogenicity of TT viruses. Curr Top Microbiol Immunol 331: 1-20.
29. Ninomiya M, Takahashi M, Nishizawa T, Shimosegawa T, Okamoto H, (2008) Development of PCR assays with nested primers specific for differential detection of three human anelloviruses and early acquisition of dual or triple infection during infancy. J Clin Microbiol 46: 507-514.
30. Deng X, Terunuma H, Handema R, Sakamoto M, Kitamura T, et al. (2000) Higher prevalence and viral load of TT virus in saliva than in the corresponding serum: another possible transmission route and replication site of TT virus. J Med Virol 62: 531-537.
31. Gallian P, Biagini P, Zhong S, Touinssi M, Yeo W, et al. (2000) TT virus: a study of molecular epidemiology and transmission of genotypes 1, 2 and 3. J Clin Virol 17: 43-49.
32. Ishikawa T, Hamano Y, Okamoto H, (1999) Frequent detection of TT virus in throat swabs of pediatric patients. Infection 27: 298.
33. Vasconcelos HC, Cataldo M, Niel C, (2002) Mixed infections of adults and children with multiple TTV-like mini virus isolates. J Med Virol 68: 291-298.
34. Gerner P, Oettinger R, Gerner W, Falbrede J, Wirth S, (2000) Mother-to-infant transmission of TT virus: prevalence, extent and mechanism of vertical transmission. Pediatr Infect Dis J 19: 1074-1077.
35. Toyoda H, Naruse M, Yokozaki S, Morita K, Nakano I, et al. (1999) Prevalence of infection with TT virus (TTV), a novel DNA virus, in healthy Japanese subjects, newborn infants, cord blood and breast milk. J Infect 38: 198-199.
36. Okamoto H, Nishizawa T, Takahashi M, Asabe S, Tsuda F, et al. (2001) Heterogeneous distribution of TT virus of distinct genotypes in multiple tissues from infected humans. Virology 288: 358-368.
37. Maggi F, Pifferi M, Tempestini E, Fornai C, Lanini L, et al. (2003) TT virus loads and lymphocyte subpopulations in children with acute respiratory diseases. J Virol 77: 9081-9083.
38. Maggi F, Fornai C, Zaccaro L, Morrica A, Vatteroni ML, et al. (2001) TT virus (TTV) loads associated with different peripheral blood cell types and evidence for TTV replication in activated mononuclear cells. J Med Virol 64: 190-194.
39. Mariscal LF, Lopez-Alcorocho JM, Rodriguez-Inigo E, Ortiz-Movilla N, de Lucas S, et al. (2002) TT virus replicates in stimulated but not in nonstimulated peripheral blood mononuclear cells. Virology 301: 121-129.
40. Ott C, Duret L, Chemin I, Trepo C, Mandrand B, et al. (2000) Use of a TT virus ORF1 recombinant protein to detect anti-TT virus antibodies in human sera. J Gen Virol 81: 2949-2958.
41. Sugiyama K, Goto K, Ando T, Mizutani F, Terabe K, et al. (1999) Route of TT virus infection in children. J Med Virol 59: 204-207.
42. Goto K, Sugiyama K, Ando T, Mizutani F, Terabe K, et al. (2000) Detection rates of TT virus DNA in serum of umbilical cord blood, breast milk and saliva. Tohoku J Exp Med 191: 203-207.
43. Hsieh SY, Wu YH, Ho YP, Tsao KC, Yeh CT, et al. (1999) High prevalence of TT virus infection in healthy children and adults and in patients with liver disease in Taiwan. J Clin Microbiol 37: 1829-1831.
44. Lin HH, Kao JH, Lee PI, Chen DS, (2002) Early acquisition of TT virus in infants: possible minor role of maternal transmission. J Med Virol 66: 285-290.
45. Niska R, Bhuiya F, Xu J (2010) National Hospital Ambulatory Medical Care Survey: 2007 emergency department summary. Natl Health Stat Report: 1-31.
46. Ishimine P, (2006) Fever without source in children 0 to 36 months of age. Pediatr Clin North Am 53: 167-194.
47. Wandinger K, Jabs W, Siekhaus A, Bubel S, Trillenberg P, et al. (2000) Association between clinical disease activity and Epstein-Barr virus reactivation in MS. Neurology 55: 178-184.
48. Heim A, Ebnet C, Harste G, Pring-Akerblom P, (2003) Rapid and quantitative detection of human adenovirus DNA by real-time PCR. J Med Virol 70: 228-239.
49. Cone RW, Huang ML, Hackman RC, Corey L, (1996) Coinfection with human herpesvirus 6 variants A and B in lung tissue. J Clin Microbiol 34: 877-881.
50. Wylie KM, Mihindukulasuriya KA, Sodergren E, Weinstock GM, Storch GA, (2012) Sequence analysis of the human virome in febrile and afebrile children. PLoS One 7: e27735.
51. Rocchi J, Ricci V, Albani M, Lanini L, Andreoli E, et al. (2009) Torquetenovirus DNA drives proinflammatory cytokines production and secretion by immune cells via toll-like receptor 9. Virology 394: 235-242.
52. Desai SM, Muerhoff AS, Leary TP, Erker JC, Simons JN, et al. (1999) Prevalence of TT virus infection in US blood donors and populations at risk for acquiring parenterally transmitted viruses. J Infect Dis 179: 1242-1244.
53. Simmonds P, Prescott LE, Logue C, Davidson F, Thomas AE, et al. (1999) TT virus-part of the normal human flora? J Infect Dis 180: 1748-1750.
54. Colvin J, Muenzer J, Jaffe D, Smason A, Deych E, et al. (2012) Detection of viruses in young children with fever without an apparent source. Pediatrics (in press).