Phosphodiesterase-4 inhibition improves corticosteroid insensitivity in pulmonary endothelial cells under oxidative stress

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 68, Issue 1, 2013, Pages 64-73

  Ortiz, J L ^a   Milara, J ^b,c   Lluch, J ^d   De Diego, A ^e   Sanz, C ^f   Cortijo, J ^a,b,d  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

^c UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

^e HOSPITAL UNIVERSITARIO LA FE   (Spain)

^f UNIVERSIDAD EUROPEA DE MADRID   (Spain)

Author keywords

cigarette smoke; glucocorticoid insensitivity; phosphodiesterase 4 inhibitor; pulmonary artery endothelial cells

Indexed keywords

CIGARETTE SMOKE; CORTICOSTEROID; CYCLIC AMP; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; INTERLEUKIN 8; ISOENZYME; PHOSPHODIESTERASE 4A; PHOSPHODIESTERASE 4B; PHOSPHODIESTERASE 4C; PHOSPHODIESTERASE 4D; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLORIMETRY; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG POTENTIATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ENDOTHELIUM; OXIDATIVE STRESS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SUPERNATANT;

ADRENAL CORTEX HORMONES; APOPTOSIS; CELL PROLIFERATION; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DEXAMETHASONE; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HUMANS; INTERLEUKIN-8; LUNG; OXIDATIVE STRESS; PHOSPHODIESTERASE 4 INHIBITORS; REACTIVE OXYGEN SPECIES; RECEPTORS, GLUCOCORTICOID; ROLIPRAM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84870610363     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12055     Document Type: Article

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