Cytokine biosensors: The future of infectious disease diagnosis?

Expert Review of Anti-Infective Therapy

Volumn 10, Issue 10, 2012, Pages 1079-1081

  Zhou, Qing ^a   Kwa, Timothy ^a   Liu, Ying ^a   Revzin, Alexander ^a  

^a University of California Davis   (United States)

Author keywords

biosensor; cytokine detection; infectious disease diagnosis

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; TUMOR NECROSIS FACTOR ALPHA;

BIOENGINEERING; BIOLOGICAL MONITORING; BIOSENSOR; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE RELEASE; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FALSE POSITIVE RESULT; FLOW CYTOMETRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOLOGICAL PROCEDURES; INTERFERON GAMMA RELEASE ASSAY; LABORATORY TEST; LATENT TUBERCULOSIS; MEDICAL TECHNOLOGY; MOLECULAR DYNAMICS; NONHUMAN; PARASITOSIS; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; TUBERCULIN TEST; TUBERCULOSIS;

BIOSENSING TECHNIQUES; COMMUNICABLE DISEASES; CYTOKINES; HUMANS; IMMUNITY, CELLULAR; INTERFERON-GAMMA;

EID: 84870609714     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/eri.12.102     Document Type: Review

References (19)

1. Lalvani A, Pareek M. Interferon-γ release assays: principles and practice. Enferm. Infecc. Microbiol. Clin. 28(4), 245-252 (2010).
2. Casey R, Blumenkrantz D, Millington K et al. Enumeration of functional T-cell subsets by fuorescence-immunospot defnes signatures of pathogen burden in tuberculosis. PLoS ONE 5(12), e15619 (2010).
3. Harari A, Rozot V, Enders FB et al. Dominant TNF-α+ Mycobacterium tuberculosis-specifc CD4+ T-cell responses discriminate between latent infection and active disease. Nat. Med. 17(3), 372-376 (2011).
4. Walzl G, Ronacher K, Hanekom W, Scriba TJ, Zumla A. Immunological biomarkers of tuberculosis. Nat. Rev. Immunol. 11(5), 343-354 (2011).
5. Kragsbjerg P, Jones I, Vikerfors T, Holmberg H. Diagnostic value of blood cytokine concentrations in acute pneumonia. Thorax 50(12), 1253-1257 (1995).
6. Pantaleo G, Harari A. Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases. Nat. Rev. Immunol. 6(5), 417-423 (2006).
7. Katsikis PD, Mueller YM, Villinger F. The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point? PLoS Pathog. 7(8), e1002055 (2011).
8. Angulo I, Fresno M. Cytokines in the pathogenesis of and protection against malaria. Clin. Diagn. Lab. Immunol. 9(6), 1145-1152 (2002).
9. Turlej E. [Novel methods of cytokine detection: real-time PCR, ELISPOT, and intracellular cytokine staining]. Postepy. Hig. Med. Dosw. 63, 213-224 (2009).
10. Toner M, Irimia D. Blood-on-a-chip. Annu. Rev. Biomed. Eng. 7, 77-103 (2005).
11. Whitesides GM, Love JC. The art of building small. Sci. Am. 9, 39-47 (2001).
12. Ma C, Fan R, Ahmad H et al. A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells. Nat. Med. 17(6), 738-743 (2011).
13. Han Q, Bradshaw EM, Nilsson B, Hafer DA, Love JC. Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab Chip 10(11), 1391-1400 (2010).
14. Stybayeva G, Mudanyali O, Seo S et al. Lensfree holographic imaging of antibody microarrays for high-throughput detection of leukocyte numbers and function. Anal. Chem. 82(9), 3736-3744 (2010).
15. Zhu H, Stybayeva G, Macal M et al. A microdevice for multiplexed detection of T-cell-secreted cytokines. Lab Chip 8(12), 2197-2205 (2008).
16. Xiao Y, Lubin AA, Heeger AJ, Plaxco K W. Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor. Angew. Chem. Int. Ed. Engl. 44(34), 5456-5459 (2005).
17. Tuleuova N, Revzin A. Micropatterning of aptamer beacons to create cytokine-sensing surfaces. Cell. Mol. Bioeng. 3(4), 337-344 (2010).
18. Liu Y, Yan J, Howland MC, Kwa T, Revzin A. Micropatterned aptasensors for continuous monitoring of cytokine release from human leukocytes. Anal. Chem. 83(21), 8286-8292 (2011).
19. Liu Y, Kwa T, Revzin A. Simultaneous detection of cell-secreted TNF-α and IFN-γ using micropatterned aptamer-modifed electrodes. Biomaterials (33)30, 7347-7355 (2012).