Fraction of exhaled nitric oxide and bronchial responsiveness are associated and continuous traits in young children independent of asthma

Chest

Volumn 142, Issue 6, 2012, Pages 1562-1568

  Schoos, Ann Marie Malby ^a   Chawes, Bo Lund Krogsgaard ^a   Bønnelykke, Klaus ^a   Bisgaard, Hans ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; CORTICOSTEROID; NITRIC OXIDE;

AIRWAY RESISTANCE; ALLERGIC RHINITIS; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CHILD; CONTROLLED STUDY; DENMARK; FEMALE; FRACTION OF EXHALED NITRIC OXIDE; HUMAN; HYPERVENTILATION; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY TRACT PARAMETERS; SEX; UPPER RESPIRATORY TRACT INFECTION;

EID: 84870583747     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.12-0658     Document Type: Article

References (24)

1. Petsky HL, Cates CJ, Li A, Kynaston JA, Turner C, Chang AB. Tailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adults. Cochrane Database Syst Rev. 2009;(4):CD006340.
2. Pijnenburg MW, Hofhuis W, Hop WC, De Jongste JC. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax. 2005;60(3):215-218. (Pubitemid 40380280)
3. Zacharasiewicz A, Wilson N, Lex C, et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med. 2005;171(10):1077-1082. (Pubitemid 40663717)
4. Buchvald F, Bisgaard H. FeNO measured at fixed exhalation flow rate during controlled tidal breathing in children from the age of 2 yr. Am J Respir Crit Care Med. 2001;163(3 pt 1):699-704. (Pubitemid 32230832)
5. Moeller A, Diefenbacher C, Lehmann A, et al. Exhaled nitric oxide distinguishes between subgroups of preschool children with respiratory symptoms. J Allergy Clin Immunol. 2008;121(3):705-709.
6. Nielsen KG, Bisgaard H. Lung function response to cold air challenge in asthmatic and healthy children of 2-5 years of age. Am J Respir Crit Care Med. 2000;161(6):1805-1809. (Pubitemid 30418111)
7. Nielsen KG, Bisgaard H. Cold air challenge and specific airway resistance in preschool children. Paediatr Respir Rev. 2005;6(4):255-266. (Pubitemid 41722607)
8. Brasholt M, Baty F, Bisgaard H. Physical activity in young children is reduced with increasing bronchial responsiveness. J Allergy Clin Immunol. 2010;125(5):1007-1012.
9. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP; STROBE Initiative. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 2007;335(7624):806-808. (Pubitemid 350057266)
10. Bisgaard H. The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study. Ann Allergy Asthma Immunol. 2004;93(4):381-389. (Pubitemid 39382980)
11. Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F. Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med. 2006;354(19):1998-2005.
12. Bisgaard H, Hermansen MN, Buchvald F, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med. 2007;357(15):1487-1495. (Pubitemid 47572634)
13. Bisgaard H, Klug B. Lung function measurement in awake young children. Eur Respir J. 1995;8(12):2067-2075.
14. Bisgaard H, Nielsen KG. Plethysmographic measurements of specific airway resistance in young children. Chest. 2005;128(1):355-362. (Pubitemid 40994495)
15. American Thoracic Society; European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med. 2005;171(8):912-930.
16. Chawes BL, Kreiner-Møller E, Bisgaard H. Objective assessments of allergic and nonallergic rhinitis in young children. Allergy. 2009;64(10):1547-1553.
17. Chawes BL, Bønnelykke K, Kreiner-Møller E, Bisgaard H. Children with allergic and nonallergic rhinitis have a similar risk of asthma. J Allergy Clin Immunol. 2010;126(3): 67-573.
18. Nielsen KG, Bisgaard H. Hyperventilation with cold versus dry air in 2- to 5-year-old children with asthma. Am J Respir Crit Care Med. 2005;171(3):238-241.
19. Van Schoor J, Joos GF, Pauwels RA. Indirect bronchial hyperresponsiveness in asthma: mechanisms, pharmacology and implications for clinical research. Eur Respir J. 2000;16(3):514-533.
20. Malmberg LP, Pelkonen AS, Haahtela T, Turpeinen M. Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma. Thorax. 2003;58(6):494-499. (Pubitemid 36714010)
21. de Jongste JC, Carraro S, Hop WC, Baraldi E; CHARISM Study Group. Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. Am J Respir Crit Care Med. 2009;179(2):93-97.
22. Shaw DE, Berry MA, Thomas M, et al. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am J Respir Crit Care Med. 2007;176(3):231-237. (Pubitemid 47195872)
23. Szefler SJ, Mitchell H, Sorkness CA, et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet. 2008;372(9643):1065-1072.
24. Stern DA, Morgan WJ, Halonen M, Wright AL, Martinez FD. Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adult hood: a longitudinal birth-cohort study. Lancet. 2008;372(9643):1058-1064.