The effect of CYP3A inhibitors and inducers on the pharmacokinetics of telaprevir in healthy volunteers

British Journal of Clinical Pharmacology

Volumn 75, Issue 2, 2013, Pages 431-439

  Garg, Varun ^a   Chandorkar, Gurudatt ^b   Yang, Yijun ^c   Adda, Nathalie ^a   Mcnair, Lindsay ^d   Alves, Katia ^a   Smith, Frances ^a   van Heeswijk, Rolf P G ^e  

^a VERTEX PHARMACEUTICALS   (United States)

^b CUBIST PHARMACEUTICALS INC   (United States)

^c Acceleron Pharma Inc   (United States)

^d Equipoise Consulting LLC   (United States)

^e JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

CYP3A4; Drug interaction; HCV; Pharmacokinetics and drug metabolism; Telaprevir

Indexed keywords

CYTOCHROME P450 3A; CYTOCHROME P450 3A INHIBITOR; CYTOCHROME P450 INHIBITOR; EFAVIRENZ; KETOCONAZOLE; RIFAMPICIN; TELAPREVIR; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; AGITATION; AREA UNDER THE CURVE; ARTICLE; CHROMATURIA; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; FEMALE; GEOMETRY; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; REGRESSION ANALYSIS; SIDE EFFECT; SINGLE DRUG DOSE; SINUS CONGESTION; STEADY STATE; VOMITING;

ADULT; AREA UNDER CURVE; BENZOXAZINES; CLINICAL TRIALS AS TOPIC; CYTOCHROME P-450 CYP3A; DRUG COMBINATIONS; DRUG INTERACTIONS; ENZYME INHIBITORS; FEMALE; HUMANS; KETOCONAZOLE; MALE; MIDDLE AGED; OLIGOPEPTIDES; RIFAMPIN;

EID: 84870571194     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2012.04345.x     Document Type: Article

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