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Volumn 14, Issue 5, 2012, Pages 522-529

Immunoglobulins in adult sepsis and septic shock

Author keywords

Adjunctive therapy; Immunoglobulins; Sepsis; Septic shock; Severe sepsis; Therapy

Indexed keywords

IMMUNOGLOBULIN; PLACEBO;

EID: 84870555414     PISSN: 15233847     EISSN: 15343146     Source Type: Journal    
DOI: 10.1007/s11908-012-0287-z     Document Type: Review
Times cited : (9)

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    • Although all of the metaanalyses from Ref. 41 to Ref. 48 are important, this one was performed in a sound matter
    • Laupland KB, Kirkpatrick AW, Delaney A. Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: a systematic review and meta-Analysis. Crit Care Med. 2007;35:2686-92. Although all of the metaanalyses from Ref. 41 to Ref. 48 are important, this one was performed in a sound matter..
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    • Intravenous immunoglobulin for treating sepsis severe sepsis and septic shock (review)
    • doi:10.1002/14651858.CD001090. Together with Ref. 41, this review is the confirming analysis for the limited evidence on the use of ivIG in adult patients with sepsis
    • Alejandria MM, Lansang MA, Dans LF, Mantaring JB. Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (review). Cochrane Library. 2010; doi:10.1002/14651858.CD001090. Together with Ref. 41, this review is the confirming analysis for the limited evidence on the use of ivIG in adult patients with sepsis.
    • (2010) Cochrane Library
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    • An evaluation of the feasibility cost and value of information of a multicenter randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock): Incorporating a systematic review meta-Analysis and value of information analysis
    • Definitely a " must" for everybody who wants sufficient information on this topic. Many sub-Analyses, many graphs, something like a "handbook" for EBM in severe sepsis
    • Soares MO, Welton NJ, Harrison DA, et al. An evaluation of the feasibility, cost and value of information of a multicenter randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock): incorporating a systematic review, meta-Analysis and value of information analysis. Health Technol Assess. 2012;16:1-186. Definitely a "must" for everybody who wants sufficient information on this topic. Many sub-Analyses, many graphs, something like a "handbook" for EBM in severe sepsis..
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    • Soares, M.O.1    Welton, N.J.2    Harrison, D.A.3
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    • Score-based immunoglobulin g therapy of patients with sepsis: The sbits study
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    • Werdan, K.1    Pilz, G.2    Bujdoso, O.3
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    • for the INIS Collaborative Group Extremely important, large RCT, although limited to very low weight newborns
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    • The only available, good quality trial on the use of IgM-enriched ivIG in adult septic patients
    • Hentrich M, Fehnle K, Ostermann H, et al. IgM-enriched immunoglobulin in neutropenic patients with sepsis syndrome and septic shock: a randomized, controlled, multiple-center trial. Crit Care Med. 2006;34:1319-25. The only available, good quality trial on the use of IgM-enriched ivIG in adult septic patients..
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