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Systematic analysis of the quality of different ivIG preparations demonstrating the potential impact on the design and outcome of clinical trials
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Schrage B, Duan G, Yang LP, Fraser JD, Proft T. Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: implications for treatment of streptococcal toxic shock syndrome. Clin Infect Dis. 2006;43:743-6. Systematic analysis of the quality of different ivIG preparations demonstrating the potential impact on the design and outcome of clinical trials..
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First class review for readers that are interested in the broad field pathophysiology, pharmacodynamics, of clinical use of ivIG, especially in patients with inflammatory and autoimmune diseases
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Kazatchkine MD, Kaveri SV. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med. 2001;345:747-55. First class review for readers that are interested in the broad field pathophysiology, pharmacodynamics, of clinical use of ivIG, especially in patients with inflammatory and autoimmune diseases..
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Our favorite review on the complex pathways by which ivIG preparations exert immunomodulatory effects
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Durandy A, Kaveri SV, Kuijpers TW, et al. Intravenous immunoglobulins -understanding properties and mechanisms. Clin Exp Immunol. 2009;158 Suppl 1:2-13. Our favorite review on the complex pathways by which ivIG preparations exert immunomodulatory effects..
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Ramakrishna C, Newo ANS, Shen YW, Cantin E. Passively administered pooled human immunoglobulins exert IL-10 dependent anti-inflammatory effects that protect against fatal HSV encephalitis. PLoS Pathogen. 2011;7:e1002071.
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Excellent review especially for readers from the area of neurology and congenital syndromes where ivIG preparations are part of standard therapy
-
Hartung HP, Mouthon L, Ahmed R, et al. Clinical applications of intravenous immunoglobulins (IVIg) -beyond immunodeficiencies and neurology. Clin Exp Immunol. 2009;158 Suppl 1:23-33. Excellent review especially for readers from the area of neurology and congenital syndromes where ivIG preparations are part of standard therapy.
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Clin Exp Immunol
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Fang KC. Monoclonal antibodies to endotoxin in the management of sepsis. West J Med. 1993;158:393-9.
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Definitely a " milestone" paper, although the results were disappointing. Readers will learn a lot!
-
Ziegler EJ, Fisher Jr. CJ, Sprung CL, et al. Treatment of gramnegative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin -A randomized, double-blind, placebo-controlled trial. N Engl J Med. 1991;324:429-36. Definitely a "milestone" paper, although the results were disappointing. Readers will learn a lot!.
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N Engl J Med
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Albertson TE, Panacek EA, MacArthur RD, et al. Multicenter evaluation of a human monoclonal antibody to Enterobacteriaceae common antigen in patients with Gram-negative sepsis. Crit Care Med. 2003;31:419-27.
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Shah SS, Hall M, Srivastava R, Subramony A, Levin JE. Intravenous immunoglobulin in children with streptococcal toxic shock syndrome. Clin Infect Dis. 2009;49:1369-76.
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33
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Kaul R, McGeer A, Norrby-Teglund A, et al. Intravenous immunoglobulin therapy for streptococcal toxic shock syndrome -A comparative observational study. Clin Infect Dis. 1999;28:800-7.
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34
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The most important study on ivIG in streptococcal toxic shock syndrome, still being the base for recommendations for the use of ivIG in these patients
-
Darenberg J, Ihendyane N, Sjölin J, et al. Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2003;37:333-40. The most important study on ivIG in streptococcal toxic shock syndrome, still being the base for recommendations for the use of ivIG in these patients..
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Clin Infect Dis
, vol.37
, pp. 333-40
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Darenberg, J.1
Ihendyane, N.2
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Valiquette L, Low DE, McGeer AJ. Assessing the impact of intravenous immunoglobulin in the management of streptococcal toxic shock syndrome: a noble but difficult question. Clin Infect Dis. 2009;49:1377-9.
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Vincent JL, Sun Q, Dubois MJ. Clinical trials of immunomodulatory therapies in severe sepsis and septic shock. Clin Infect Dis. 2002;34:1084-93.
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Laupland KB. Polyclonal intravenous immunoglobulin for the treatment of infection in critically ill patients. Can J Infect Dis. 2002;13:100-6.
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Accessed 6 August 2012
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Alejandria MM, Lansang MA, Dans LF, Mantaring JB. Intravenous immunoglobulin for treating sepsis and septic shock. Cochrane Database Syst Rev. 2002;1:CD001090. http://www.ncbi.nlm.nih.gov/pubmed/11869591. Accessed 6 August 2012.
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Pildal J, Gotzsche PC. Polyclonal immunoglobulin for treatment of bacterial sepsis: a systematic review. Clin Infect Dis. 2004;39:38-46.
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Clin Infect Dis
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Pildal, J.1
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Turgeon AF, Hutton B, Fergusson DA, et al. Metaanalysis: intravenous immunoglobulin in critically ill adult patients with sepsis. Ann Intern Med. 2007;146:193-203.
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Although all of the metaanalyses from Ref. 41 to Ref. 48 are important, this one was performed in a sound matter
-
Laupland KB, Kirkpatrick AW, Delaney A. Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: a systematic review and meta-Analysis. Crit Care Med. 2007;35:2686-92. Although all of the metaanalyses from Ref. 41 to Ref. 48 are important, this one was performed in a sound matter..
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Crit Care Med
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Laupland, K.B.1
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Kreymann KG, de Heer G, Nierhaus A, Kluge S. Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock. Crit Care Med. 2007;35:2677-85.
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Kreymann, K.G.1
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45
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doi:10.1002/14651858.CD001090. Together with Ref. 41, this review is the confirming analysis for the limited evidence on the use of ivIG in adult patients with sepsis
-
Alejandria MM, Lansang MA, Dans LF, Mantaring JB. Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (review). Cochrane Library. 2010; doi:10.1002/14651858.CD001090. Together with Ref. 41, this review is the confirming analysis for the limited evidence on the use of ivIG in adult patients with sepsis.
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(2010)
Cochrane Library
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Alejandria, M.M.1
Lansang, M.A.2
Dans, L.F.3
Mantaring, J.B.4
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46
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84857879859
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An evaluation of the feasibility cost and value of information of a multicenter randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock): Incorporating a systematic review meta-Analysis and value of information analysis
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Definitely a " must" for everybody who wants sufficient information on this topic. Many sub-Analyses, many graphs, something like a "handbook" for EBM in severe sepsis
-
Soares MO, Welton NJ, Harrison DA, et al. An evaluation of the feasibility, cost and value of information of a multicenter randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock): incorporating a systematic review, meta-Analysis and value of information analysis. Health Technol Assess. 2012;16:1-186. Definitely a "must" for everybody who wants sufficient information on this topic. Many sub-Analyses, many graphs, something like a "handbook" for EBM in severe sepsis..
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(2012)
Health Technol Assess.
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, pp. 1-186
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Soares, M.O.1
Welton, N.J.2
Harrison, D.A.3
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47
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Score-based immunoglobulin g therapy of patients with sepsis: The sbits study
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The most important RCTon ivIG in adult patients with severe sepsis
-
Werdan K, Pilz G, Bujdoso O, et al. Score-based immunoglobulin G therapy of patients with sepsis: The SBITS study. Crit Care Med. 2007;35:2693-701. The most important RCTon ivIG in adult patients with severe sepsis..
-
(2007)
Crit Care Med
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, pp. 2693-701
-
-
Werdan, K.1
Pilz, G.2
Bujdoso, O.3
-
48
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-
80053367664
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-
for the INIS Collaborative Group Extremely important, large RCT, although limited to very low weight newborns
-
Brocklehurst P, Farrell B, King A, for the INIS Collaborative Group, et al. Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med. 2011;365:1201-11. Extremely important, large RCT, although limited to very low weight newborns..
-
(2011)
N Engl J Med
, vol.365
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