ICUD-EAU international consultation on bladder cancer 2012: Radical cystectomy and bladder preservation for muscle-invasive urothelial carcinoma of the bladder

European Urology

Volumn 63, Issue 1, 2013, Pages 45-57

  Gakis, Georgios ^a   Efstathiou, Jason ^b   Lerner, Seth P ^c   Cookson, Michael S ^d   Keegan, Kirk A ^d   Guru, Khurshid A ^e   Shipley, William U ^b   Heidenreich, Axel ^f   Schoenberg, Mark P ^g   Sagaloswky, Arthur I ^h   Soloway, Mark S ⁱ   Stenzl, Arnulf ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e ROSWELL PARK CANCER INSTITUTE   (United States)

^f UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^g DEPARTMENT OF PATHOLOGY   (United States)

^h UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

ⁱ UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Bladder cancer; Bladder preservation; Guidelines; Radical cystectomy; Recommendations

Indexed keywords

CISPLATIN; FLUOROURACIL; GEMCITABINE; METHOTREXATE; MITOMYCIN C; VINBLASTINE;

AGE; BLADDER; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER RADIOTHERAPY; CANCER SPECIFIC SURVIVAL; CYSTECTOMY; DEEP VEIN THROMBOSIS; EVIDENCE BASED MEDICINE; EXTERNAL BEAM RADIOTHERAPY; FOLLOW UP; HUMAN; LAPAROSCOPIC SURGERY; LUNG EMBOLISM; LYMPH NODE DISSECTION; MORBIDITY; MULTICENTER STUDY (TOPIC); NON MUSCLE INVASIVE BLADDER CANCER; ORGAN PRESERVATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTATE; QUALITY OF LIFE; RETROSPECTIVE STUDY; REVIEW; SEMINAL VESICLE; SEX DIFFERENCE; THROMBOEMBOLISM; TRANSITIONAL CELL CARCINOMA; TRANSURETHRAL RESECTION; TUMOR RECURRENCE; URETER; URETHRA; UTERUS; VAGINA;

CARCINOMA; CHEMORADIOTHERAPY; CYSTECTOMY; DISEASE PROGRESSION; FEMALE; HUMANS; LAPAROSCOPY; LYMPH NODE EXCISION; MALE; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; ORGAN SPARING TREATMENTS; TREATMENT OUTCOME; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 84870506781     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2012.08.009     Document Type: Review

References (105)

1. R.E. Hautmann, J.E. Gschwend, R.C. de Petriconi, M. Kron, and B.G. Volkmer Cystectomy for transitional cell carcinoma of the bladder: results of a surgery only series in the neobladder era J Urol 176 2006 486 492 discussion 491-2
2. J.P. Stein, G. Lieskovsky, and R. Cote Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients J Clin Oncol 19 2001 666 675
3. G. Dalbagni, K. Vora, and M. Kaag Clinical outcome in a contemporary series of restaged patients with clinical T1 bladder cancer Eur Urol 56 2009 903 910
4. D.S. Morris, A.Z. Weizer, Z. Ye, R.L. Dunn, J.E. Montie, and B.K. Hollenbeck Understanding bladder cancer death: tumor biology versus physician practice Cancer 115 2009 1011 1020
5. J.L. Gore, J. Lai, C.M. Setodji, M.S. Litwin, and C.S. Saigal Mortality increases when radical cystectomy is delayed more than 12 weeks: results from a Surveillance, Epidemiology, and End Results-Medicare analysis Cancer 115 2009 988 996
6. E. Scosyrev, K. Noyes, C. Feng, and E. Messing Sex and racial differences in bladder cancer presentation and mortality in the US Cancer 115 2009 68 74
7. A.M. Kamat, C.P. Dinney, and J.R. Gee Micropapillary bladder cancer: a review of the University of Texas M. D. Anderson Cancer Center experience with 100 consecutive patients Cancer 110 2007 62 67
8. J. Wang, F.W. Wang, C.A. LaGrange, G.P. Hemstreet III, and A. Kessinger Clinical features of sarcomatoid carcinoma (carcinosarcoma) of the urinary bladder: analysis of 221 cases Sarcoma 2010 2010 454792
9. A.O. Siefker-Radtke, J. Gee, and Y. Shen Multimodality management of urachal carcinoma: the M. D. Anderson Cancer Center experience J Urol 169 2003 1295 1298
10. E. Scosyrev, B.W. Ely, and E.M. Messing Do mixed histological features affect survival benefit from neoadjuvant platinum-based combination chemotherapy in patients with locally advanced bladder cancer? A secondary analysis of Southwest Oncology Group-Directed Intergroup Study (S8710) BJU Int 108 2011 693 699
11. J.R. Eswara, J.A. Efstathiou, and N.M. Heney Complications and long-term results of salvage cystectomy after failed bladder sparing therapy for muscle invasive bladder cancer J Urol 187 2012 463 468
12. J.A. Efstathiou, D.Y. Spiegel, and W.U. Shipley Long-term outcomes of selective bladder preservation by combined-modality therapy for invasive bladder cancer: the MGH experience Eur Urol 61 2012 705 711
13. U. Nagele, A.G. Anastasiadis, and A.S. Merseburger The rationale for radical cystectomy as primary therapy for T4 bladder cancer World J Urol 25 2007 401 405
14. A. Stenzl, U. Nagele, and M. Kuczyk Cystectomy - technical considerations in male and female patients Eur Urol Suppl 3 2005 138 146
15. G. Gakis, D. Schilling, J. Bedke, K.D. Sievert, and A. Stenzl Incidental prostate cancer at radical cystoprostatectomy: implications for apex-sparing surgery BJU Int 105 2010 468 471
16. A. Stenzl, L. Jarolim, and P. Coloby Urethra-sparing cystectomy and orthotopic urinary diversion in women with malignant pelvic tumors Cancer 92 2001 1864 1871
17. D. Schilling, M. Horstmann, U. Nagele, K.-D. Sievert, and A. Stenzl Cystectomy in women BJU Int 102 2008 1289 1295
18. J. Nix, A. Smith, R. Kurpad, M.E. Nielsen, E.M. Wallen, and R.S. Pruthi Prospective randomized controlled trial of robotic versus open radical cystectomy for bladder cancer: perioperative and pathologic results Eur Urol 57 2010 196 201
19. J. Leissner, M.A. Ghoneim, and H. Abol-Enein Extended radical lymphadenectomy in patients with urothelial bladder cancer: results of a prospective multicenter study J Urol 171 2004 139 144
20. N.B. Dhar, E.A. Klein, A.M. Reuther, G.N. Thalmann, S. Madersbacher, and U.E. Studer Outcome after radical cystectomy with limited or extended pelvic lymph node dissection J Urol 179 2008 873 878
21. K. Steven, and A.L. Poulsen Radical cystectomy and extended pelvic lymphadenectomy: survival of patients with lymph node metastasis above the bifurcation of the common iliac vessels treated with surgery only J Urol 178 2007 1218 1223
22. A. Fleischmann, G.N. Thalmann, R. Markwalder, and U.E. Studer Extracapsular extension of pelvic lymph node metastases from urothelial carcinoma of the bladder is an independent prognostic factor J Clin Oncol 23 2005 2358 2365
23. B. Roth, P. Zehnder, F.D. Birkhauser, F.C. Burkhard, G.N. Thalmann, and U.E. Studer Is bilateral extended pelvic lymphadenectomy necessary for strictly unilateral invasive bladder cancer? J Urol 187 2012 1577 1582
24. H.W. Herr, J.R. Faulkner, and H.B. Grossman Surgical factors influence bladder cancer outcomes: a cooperative group report J Clin Oncol 22 2004 2781 2789
25. B.H. Bochner, D. Cho, H.W. Herr, M. Donat, M.W. Kattan, and G. Dalbagni Prospectively packaged lymph node dissections with radical cystectomy: evaluation of node count variability and node mapping J Urol 172 2004 1286 1290
26. T.M. Koppie, A.J. Vickers, K. Vora, G. Dalbagni, and B.H. Bochner Standardization of pelvic lymphadenectomy performed at radical cystectomy: can we establish a minimum number of lymph nodes that should be removed? Cancer 107 2006 2368 2374
27. G. Gakis, D. Schilling, S. Perner, C. Schwentner, K.D. Sievert, and A. Stenzl Sequential resection of malignant ureteral margins at radical cystectomy: a critical assessment of the value of frozen section analysis World J Urol 29 2011 451 456
28. W. Kassouf, P. Spiess, and G. Brown Prostatic urethral biopsy has limited usefulness in counseling patients regarding final urethral margin status during orthotopic neobladder reconstruction J Urol 180 2008 164 167
29. J.P. Stein, D. Esrig, and J.A. Freeman Prospective pathologic analysis of female cystectomy specimens: risk factors for orthotopic diversion in women Urology 51 1998 951 955
30. W. Kassouf, D. Swanson, and A.M. Kamat Partial cystectomy for muscle invasive urothelial carcinoma of the bladder: a contemporary review of the M. D. Anderson Cancer Center experience J Urol 175 2006 2058 2062
31. M.C. Smaldone, B.L. Jacobs, A.M. Smaldone, and R.L. Hrebinko Jr. Long-term results of selective partial cystectomy for invasive urothelial bladder carcinoma Urology 72 2008 613 616
32. C.N. Sternberg, V. Pansadoro, and F. Calabro Can patient selection for bladder preservation be based on response to chemotherapy? Cancer 97 2003 1644 1652
33. U. Capitanio, H. Isbarn, and S.F. Shariat Partial cystectomy does not undermine cancer control in appropriately selected patients with urothelial carcinoma of the bladder: a population-based matched analysis Urology 74 2009 858 864
34. E. Solsona, I. Iborra, J.V. Ricos, J.L. Monros, J. Casanova, and C. Calabuig Feasibility of transurethral resection for muscle infiltrating carcinoma of the bladder: long-term followup of a prospective study J Urol 159 1998 95 98
35. H. Herr Transurethral resection of muscle-invasive bladder cancer: 10-year outcome J Clin Oncol 19 2001 89 93
36. D. Leibovici, W. Kassouf, and L.L. Pisters Organ preservation for muscle-invasive bladder cancer by transurethral resection Urology 70 2007 473 476
37. L.H. Sobin, and C. Wittekind TNM classification of malignant tumours ed. 6. 2002 Wiley-Liss New York, NY
38. L.H. Sobin, M.K. Gospodarowicz, and C. Wittekind International Union Against Cancer. TNM classification of malignant tumours ed. 7. 2010 Wiley-Blackwell Hoboken, NJ
39. E. Scosyrev, J. Yao, and E. Messing Microscopic invasion of perivesical fat by urothelial carcinoma: implications for prognosis and pathology practice Urology 76 2010 908 913
40. G. Gakis, D. Schilling, M. Renninger, J. Seibold, K.D. Sievert, and A. Stenzl Comparison of the new American Joint Committee on Cancer substratification in node-negative pT2 urothelial carcinoma of the bladder: analysis of patient outcomes in a contemporary series BJU Int 107 2011 919 923
41. D. Tilki, R.S. Svatek, and P.I. Karakiewicz pT3 substaging is a prognostic indicator for lymph node negative urothelial carcinoma of the bladder J Urol 184 2010 470 474
42. S. Madersbacher, W. Hochreiter, and F. Burkhard Radical cystectomy for bladder cancer today - a homogeneous series without neoadjuvant therapy J Clin Oncol 21 2003 690 696
43. H.M. Bruins, G.J. Huang, J. Cai, D.G. Skinner, J.P. Stein, and D.F. Penson Clinical outcomes and recurrence predictors of lymph node positive urothelial cancer after cystectomy J Urol 182 2009 2182 2187
44. A.C. Fang, A.E. Ahmad, J.M. Whitson, L.D. Ferrell, P.R. Carroll, and B.R. Konety Effect of a minimum lymph node policy in radical cystectomy and pelvic lymphadenectomy on lymph node yields, lymph node positivity rates, lymph node density, and survivorship in patients with bladder cancer Cancer 116 2010 1901 1908
45. A.J. Stephenson, M.C. Gong, S.C. Campbell, A.F. Fergany, and D.E. Hansel Aggregate lymph node metastasis diameter and survival after radical cystectomy for invasive bladder cancer Urology 75 2010 382 386
46. B.H. Bochner, M.W. Kattan, and K.C. Vora Postoperative nomogram predicting risk of recurrence after radical cystectomy for bladder cancer J Clin Oncol 24 2006 3967 3972
47. P.I. Karakiewicz, S.F. Shariat, and G.S. Palapattu Nomogram for predicting disease recurrence after radical cystectomy for transitional cell carcinoma of the bladder J Urol 176 2006 1354 1361
48. S.F. Shariat, P.I. Karakiewicz, and G.S. Palapattu Nomograms provide improved accuracy for predicting survival after radical cystectomy Clin Cancer Res 12 2006 6663 6676
49. D. Zaak, M. Burger, and W. Otto Predicting individual outcomes after radical cystectomy: an external validation of current nomograms BJU Int 106 2010 342 348
50. R. Hautmann, R. de Petriconi, and B. Volkmer Lessons learned from 1,000 neobladders: the 90-day complication rate J Urol 184 2010 990 994
51. M.S. Khan, O. Elhage, B. Challacombe, P. Rimington, D. Murphy, and P. Dasgupta Analysis of early complications of robotic-assisted radical cystectomy using a standardized reporting system Urology 77 2011 357 362
52. D. Dindo, N. Demartines, and P.A. Clavien Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey Ann Surg 240 2004 205 213
53. G. Novara, V. De Marco, and M. Aragona Complications and mortality after radical cystectomy for bladder transitional cell cancer J Urol 182 2009 914 921
54. P.E. Clark, J.P. Stein, and S.G. Groshen Radical cystectomy in the elderly: comparison of clincal outcomes between younger and older patients Cancer 104 2005 36 43
55. N. Lawrentschuk, R. Colombo, and O.W. Hakenberg Prevention and management of complications following radical cystectomy for bladder cancer Eur Urol 57 2010 983 1001
56. A. Shabsigh, R. Korets, and K.C. Vora Defining early morbidity of radical cystectomy for patients with bladder cancer using a standardized reporting methodology Eur Urol 55 2009 164 176
57. R. Chahal, S.K. Sundaram, R. Iddenden, D.F. Forman, P.M.T. Weston, and S.C.W. Harrison A study of the morbidity, mortality and long-term survival following radical cystectomy and radical radiotherapy in the treatment of invasive bladder cancer in Yorkshire Eur Urol 43 2003 246 257
58. V. Novotny, O.W. Hakenberg, and D. Wiessner Perioperative complications of radical cystectomy in a contemporary series Eur Urol 51 2007 397 402
59. S.Z. Goldhaber Risk factors for venous thromboembolism J Am Coll Cardiol 56 2010 1 7
60. G. Giannarini, T.M. Kessler, H.C. Thoeny, D.P. Nguyen, C. Meissner, and U.E. Studer Do patients benefit from routine follow-up to detect recurrences after radical cystectomy and ileal orthotopic bladder substitution? Eur Urol 58 2010 486 494
61. C. Meissner, G. Giannarini, M.C. Schumacher, H. Thoeny, U.E. Studer, and F.C. Burkhard The efficiency of excretory urography to detect upper urinary tract tumors after cystectomy for urothelial cancer J Urol 178 2007 2287 2290
62. M.K. Tollefson, M.L. Blute, S.A. Farmer, and I. Frank Significance of distal ureteral margin at radical cystectomy for urothelial carcinoma J Urol 183 2010 81 86
63. K.M. Sanderson, J. Cai, G. Miranda, D.G. Skinner, and J.P. Stein Upper tract urothelial recurrence following radical cystectomy for transitional cell carcinoma of the bladder: an analysis of 1,069 patients with 10-year followup J Urol 177 2007 2088 2094
64. M.P. Schoenberg, H.B. Carter, and J.I. Epstein Ureteral frozen section analysis during cystectomy: a reassessment J Urol 155 1996 1218 1220
65. W. Tran, A.M. Serio, and G.V. Raj Longitudinal risk of upper tract recurrence following radical cystectomy for urothelial cancer and the potential implications for long-term surveillance J Urol 179 2008 96 100
66. B.G. Volkmer, T. Schnoeller, R. Kuefer, K. Gust, F. Finter, and R.E. Hautmann Upper urinary tract recurrence after radical cystectomy for bladder cancer - who is at risk? J Urol 182 2009 2632 2637
67. J.W. Slaton, D.A. Swanson, H.B. Grossman, and C.P. Dinney A stage specific approach to tumor surveillance after radical cystectomy for transitional cell carcinoma of the bladder J Urol 162 1999 710 714
68. S. Yoshimine, E. Kikuchi, and K. Matsumoto The clinical significance of urine cytology after a radical cystectomy for urothelial cancer Int J Urol 17 2010 527 532
69. M.S. Soloway, G.H. Myers Jr., J.F. Burdick, and R.A. Malmgren Ileal conduit exfoliative cytology in the diagnosis of recurrent cancer J Urol 107 1972 835 839
70. G.V. Raj, B.H. Bochner, and A.M. Serio Natural history of positive urinary cytology after radical cystectomy J Urol 176 2006 2000 2005 discussion 2005
71. J.C. Brien, S.F. Shariat, and M.P. Herman Preoperative hydronephrosis, ureteroscopic biopsy grade and urinary cytology can improve prediction of advanced upper tract urothelial carcinoma J Urol 184 2010 69 73
72. E. Solsona, I. Iborra, J. Rubio, J. Casanova, R. Dumont, and J.L. Monros Late oncological occurrences following radical cystectomy in patients with bladder cancer Eur Urol 43 2003 489 494
73. T. Akkad, C. Gozzi, and M. Deibl Tumor recurrence in the remnant urothelium of females undergoing radical cystectomy for transitional cell carcinoma of the bladder: long-term results from a single center J Urol 175 2006 1268 1271 discussion 1271
74. K.S. Cho, J.W. Seo, and S.J. Park The risk factor for urethral recurrence after radical cystectomy in patients with transitional cell carcinoma of the bladder Urol Int 82 2009 306 311
75. J.P. Stein, P. Clark, G. Miranda, J. Cai, S. Groshen, and D.G. Skinner Urethral tumor recurrence following cystectomy and urinary diversion: clinical and pathological characteristics in 768 male patients J Urol 173 2005 1163 1168
76. J. Huguet, V. Monllau, and S. Sabaté Diagnosis, risk factors, and outcome of urethral recurrences following radical cystectomy for bladder cancer in 729 male patients Eur Urol 53 2008 785 793
77. S.M. Donat, D.C. Wei, M.S. McGuire, and H.W. Herr The efficacy of transurethral biopsy for predicting the long-term clinical impact of prostatic invasive bladder cancer J Urol 165 2001 1580 1584
78. J.P. Stein, D.F. Penson, C. Lee, J. Cai, G. Miranda, and D.G. Skinner Long-term oncological outcomes in women undergoing radical cystectomy and orthotopic diversion for bladder cancer J Urol 181 2009 2052 2058
79. B. Ali-El-Dein Oncological outcome after radical cystectomy and orthotopic bladder substitution in women Eur J Surg Oncol 35 2009 320 325
80. B. Ali-el-Dein, M. Abdel-Latif, A. Ashamallah, M. Abdel-Rahim, and M. Ghoneim Local urethral recurrence after radical cystectomy and orthotopic bladder substitution in women: a prospective study J Urol 171 2004 275 278
81. J.P. Stein, R.J. Cote, and J.A. Freeman Indications for lower urinary tract reconstruction in women after cystectomy for bladder cancer: a pathological review of female cystectomy specimens J Urol 154 1995 1329 1333
82. S. Maralani, D.P. Wood, D. Grignon, M. Banerjee, W. Sakr, and J.E. Pontes Incidence of urethral involvement in female bladder cancer: an anatomic pathologic study Urology 50 1997 537 541
83. J.P. Stein, D.F. Penson, S.D. Wu, and D.G. Skinner Pathological guidelines for orthotopic urinary diversion in women with bladder cancer: a review of the literature J Urol 178 2007 756 760
84. A.M. Nieder, P.D. Sved, P. Gomez, S.S. Kim, M. Manoharan, and M.S. Soloway Urethral recurrence after cystoprostatectomy: implications for urinary diversion and monitoring Urology 64 2004 950 954
85. J.L. Nelles, B.R. Konety, C. Saigal, J. Pace, and J. Lai Urethrectomy following cystectomy for bladder cancer in men: practice patterns and impact on survival J Urol 180 2008 1933 1936
86. D.W. Lin, H.W. Herr, and G. Dalbagni Value of urethral wash cytology in the retained male urethra after radical cystoprostatectomy J Urol 169 2003 961 963
87. S.B. Stewart, R.A. Leder, and B.A. Inman Imaging tumors of the penis and urethra Urol Clin North Am 37 2010 353 367
88. C. Varol, G.N. Thalmann, F.C. Burkhard, and U.E. Studer Treatment of urethral recurrence following radical cystectomy and ileal bladder substitution J Urol 172 2004 937 942
89. J. Huguet-Perez, J. Palou, F. Millan-Rodriguez, J. Salvador-Bayarri, H. Villavicencio-Mavrich, and J. Vicente-Rodriguez Upper tract transitional cell carcinoma following cystectomy for bladder cancer Eur Urol 40 2001 318 323
90. K. Yoshida, H. Nishiyama, H. Kinoshita, T. Matsuda, and O. Ogawa Surgical treatment for urethral recurrence after ileal neobladder reconstruction in patients with bladder cancer BJU Int 98 2006 1008 1011
91. A. Stenzl, K. Colleselli, S. Poisel, H. Feichtinger, H. Pontasch, and G. Bartsch Rationale and technique of nerve sparing radical cystectomy before an orthotopic neobladder procedure in women J Urol 154 1995 2044 2049
92. A. Stenzl, H. Draxl, B. Posch, K. Colleselli, M. Falk, and G. Bartsch The risk of urethral tumors in female bladder cancer: can the urethra be used for orthotopic reconstruction of the lower urinary tract? J Urol 153 1995 950 955
93. G. Dalbagni, E. Genega, and M. Hashibe Cystectomy for bladder cancer: a contemporary series J Urol 165 2001 1111 1116
94. H.B. Grossman, R.B. Natale, and C.M. Tangen Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer N Engl J Med 349 2003 859 866
95. N.D. James, S.A. Hussain, and E. Hall Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer N Engl J Med 366 2012 1477 1488
96. W.U. Shipley, K.A. Winter, and D.S. Kaufman Phase III trial of neoadjuvant chemotherapy in patients with invasive bladder cancer treated with selective bladder preservation by combined radiation therapy and chemotherapy: initial results of Radiation Therapy Oncology Group 89-03 J Clin Oncol 16 1998 3576 3583
97. W.U. Shipley, G.R. Prout Jr., and A.B. Einstein Treatment of invasive bladder cancer by cisplatin and radiation in patients unsuited for surgery JAMA 258 1987 931 935
98. C.M. Coppin, M.K. Gospodarowicz, and K. James Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or definitive radiation. The National Cancer Institute of Canada Clinical Trials Group J Clin Oncol 14 1996 2901 2907
99. R.S. Svatek, S.F. Shariat, and G. Novara Discrepancy between clinical and pathological stage: external validation of the impact on prognosis in an international radical cystectomy cohort BJU Int 107 2011 898 904
100. J. Dunst, R. Sauer, K.M. Schrott, R. Kuhn, C. Wittekind, and A. Altendorf-Hofmann Organ-sparing treatment of advanced bladder cancer: a 10-year experience Int J Radiat Oncol Biol Phys 30 1994 261 266
101. C. Rodel, G.G. Grabenbauer, and R. Kuhn Combined-modality treatment and selective organ preservation in invasive bladder cancer: long-term results J Clin Oncol 20 2002 3061 3071
102. J.A. Efstathiou, K. Bae, and W.U. Shipley Late pelvic toxicity after bladder-sparing therapy in patients with invasive bladder cancer: RTOG 89-03, 95-06, 97-06, 99-06 J Clin Oncol 27 2009 4055 4061
103. A.L. Zietman, D. Sacco, and U. Skowronski Organ conservation in invasive bladder cancer by transurethral resection, chemotherapy and radiation: results of a urodynamic and quality of life study on long-term survivors J Urol 170 2003 1772 1776
104. O. Caffo, G. Fellin, U. Graffer, and L. Luciani Assessment of quality of life after cystectomy or conservative therapy for patients with infiltrating bladder carcinoma: a survey by a self-administered questionnaire Cancer 78 1996 1089 1097
105. L. Henningsohn, H. Wijkstrom, P.W. Dickman, K. Bergmark, and G. Steineck Distressful symptoms after radical radiotherapy for urinary bladder cancer Radiother Oncol 62 2002 215 225