-
1
-
-
78449281377
-
Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170 000 participants in 26 randomised trials
-
Cholesterol Treatment Trialists' (CTT) Collaboration
-
Cholesterol Treatment Trialists' (CTT) Collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials. Lancet 2010; 376: 1670-81.
-
(2010)
Lancet
, vol.376
, pp. 1670-1681
-
-
-
2
-
-
84870478439
-
Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): A randomised, placebocontrolled, dose-ranging, phase 2 study
-
for the LAPLACE-TIMI 57 Investigators, published online Nov 6
-
Giugliano RP, Desai NR, Kohli P, et al, for the LAPLACE-TIMI 57 Investigators. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebocontrolled, dose-ranging, phase 2 study. Lancet 2012; published online Nov 6. http://dx.doi.org/10.1016/S0140-6736(12)61770-X.
-
(2012)
Lancet
-
-
Giugliano, R.P.1
Desai, N.R.2
Kohli, P.3
-
3
-
-
84870494510
-
Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): A randomised, double-blind, placebo-controlled, phase 2 study
-
published online Nov 6
-
Koren MJ, Scott R, Kim JB, et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study. Lancet 2012; published online Nov 6. http://dx.doi.org/10.1016/S0140-6736(12)61771-1.
-
(2012)
Lancet
-
-
Koren, M.J.1
Scott, R.2
Kim, J.B.3
-
4
-
-
32444444724
-
Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients-the PRIMO study
-
Bruckert E, Hayem G, Dejager S, Yau C, Begaud B. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients-the PRIMO study. Cardiovasc Drugs Ther 2005; 19: 403-14.
-
(2005)
Cardiovasc Drugs Ther
, vol.19
, pp. 403-414
-
-
Bruckert, E.1
Hayem, G.2
Dejager, S.3
Yau, C.4
Begaud, B.5
-
5
-
-
84860383419
-
The biology and therapeutic targeting of the proprotein convertases
-
Seidah NG, Prat A. The biology and therapeutic targeting of the proprotein convertases. Nat Rev Drug Discov 2012; 11: 367-83.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 367-383
-
-
Seidah, N.G.1
Prat, A.2
-
6
-
-
66349126280
-
PCSK9: A convertase that co-ordinates LDL catabolism
-
Horton JD, Cohen JC, Hobbs HH. PCSK9: a convertase that co-ordinates LDL catabolism. J Lipid Res 2009; 50 (suppl): S172-77.
-
(2009)
J Lipid Res
, vol.50
, Issue.SUPPL.
-
-
Horton, J.D.1
Cohen, J.C.2
Hobbs, H.H.3
-
7
-
-
0037603589
-
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
-
Abifadel M, Varret M, Rabes JP, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 2003; 34: 154-56.
-
(2003)
Nat Genet
, vol.34
, pp. 154-156
-
-
Abifadel, M.1
Varret, M.2
Rabes, J.P.3
-
8
-
-
33645103550
-
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
-
Cohen, JC, Boerwinkle E, Mosley TH Jr, Hobbs HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006; 354: 1264-72.
-
(2006)
N Engl J Med
, vol.354
, pp. 1264-1272
-
-
Cohen, J.C.1
Boerwinkle, E.2
Mosley Jr., T.H.3
Hobbs, H.H.4
-
9
-
-
84868206496
-
Effect of AMG 145 on low-density lipoprotein cholesterol levels: Results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins
-
Dias CS, Shaywitz AJ, Wasserman SM, et al. Effect of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins. J Am Coll Cardiol 2012; 60: 1888-98.
-
(2012)
J Am Coll Cardiol
, vol.60
, pp. 1888-1898
-
-
Dias, C.S.1
Shaywitz, A.J.2
Wasserman, S.M.3
-
10
-
-
84863494422
-
Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial
-
Stein EA, Gipe D, Begeron J, et al. Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial. Lancet 2012; 380: 29-36.
-
(2012)
Lancet
, vol.380
, pp. 29-36
-
-
Stein, E.A.1
Gipe, D.2
Begeron, J.3
-
11
-
-
84862219022
-
Safety and efficacy of a monoclonal antibody to proprotein convertase subtilising/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
-
McKenny JM, Koren MJ, Kereiakes DJ, Hanotin C, Ferrand AC, Stein EA. Safety and efficacy of a monoclonal antibody to proprotein convertase subtilising/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol 2012; 59: 2344-53.
-
(2012)
J Am Coll Cardiol
, vol.59
, pp. 2344-2353
-
-
McKenny, J.M.1
Koren, M.J.2
Kereiakes, D.J.3
Hanotin, C.4
Ferrand, A.C.5
Stein, E.A.6
-
12
-
-
33748661502
-
Molecular characterization of loss-of-function mutations in PCSK9 and identifi cation of a compound heterozygote
-
Zhao Z, Tuakli-Wosornu, Lagace TA, et al. Molecular characterization of loss-of-function mutations in PCSK9 and identifi cation of a compound heterozygote. Am J Hum Genet 2006; 79: 514-23.
-
(2006)
Am J Hum Genet
, vol.79
, pp. 514-523
-
-
Zhao, Z.1
Tuakli-Wosornu2
Lagace, T.A.3
-
13
-
-
79952049508
-
Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents
-
Konrad RJ, Troutt JS, Cao G. Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents. Lipids Health Dis 2011; 10: 38.
-
(2011)
Lipids Health Dis
, vol.10
, pp. 38
-
-
Konrad, R.J.1
Troutt, J.S.2
Cao, G.3
-
14
-
-
48349088178
-
Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia
-
Samaha FF, McKenney J, Bloedon LT, Sasiela WJ, Rader DJ. Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia. Nat Clin Pract Cardiovasc Med 2008; 5: 497-505.
-
(2008)
Nat Clin Pract Cardiovasc Med
, vol.5
, pp. 497-505
-
-
Samaha, F.F.1
McKenney, J.2
Bloedon, L.T.3
Sasiela, W.J.4
Rader, D.J.5
-
15
-
-
77949485460
-
Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: A randomised, double-blind, placebo-controlled trial
-
Raal FJ, Santos RD, Blom DJ, et al. Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. Lancet 2010; 375: 998-1006.
-
(2010)
Lancet
, vol.375
, pp. 998-1006
-
-
Raal, F.J.1
Santos, R.D.2
Blom, D.J.3
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