Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degeneration

Cell Death and Disease

Volumn 3, Issue 11, 2012, Pages

  Wang, W ^a   Tang, Y ^a   Ni, L ^a   Kim, E ^a   Jongwutiwes, T ^a   Hourvitz, A ^b   Zhang, R ^c   Xiong, H ^c   Liu, H C ^a   Rosenwaks, Z ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b SHEBA MEDICAL CENTER   (Israel)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

BAC transgenesis; Gain of function; Oocyte; Ovarian follicle; Premature ovarian failure; Uromodulin like 1

Indexed keywords

CD3 ANTIBODY; FOLLITROPIN; GONADOTROPIN; GROWTH DIFFERENTIATION FACTOR 9; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADIPOCYTE; ADIPOGENESIS; AGING; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CD4+ T LYMPHOCYTE; CELL DEGENERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CORPUS LUTEUM; DISEASE MODEL; EMBRYO; FEMALE; FEMALE GENITAL SYSTEM; FEMALE INFERTILITY; GENE; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; GRANULOSA CELL; HISTOPATHOLOGY; IMMUNE SYSTEM; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; OOCYTE; OVARY; OVARY FOLLICLE; PATHOGENESIS; PREMATURE OVARIAN FAILURE; PRIORITY JOURNAL; STROMA CELL; TRANSGENIC MOUSE; TRANSGENICS; UROMODULIN LIKE1 GENE;

ANIMALS; ANOVULATION; APOPTOSIS; CALCIUM-BINDING PROTEINS; CORPUS LUTEUM; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; OVARIAN FOLLICLE; OVARY; PRIMARY OVARIAN INSUFFICIENCY;

ANIMALIA; MURINAE; MUS;

EID: 84870492989     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.169     Document Type: Article

References (42)

1. Richardson SJ, Senikas V, Nelson JF. Follicular depletion during the menopausal transition: evidence for accelerated loss and ultimate exhaustion. J Clin Endocrinol Metab 1987; 65: 1231-1237.
2. te Velde ER, Pearson PL. The variability of female reproductive ageing. Hum Reprod Update 2002; 8: 141-154.
3. Nikolaou D, Templeton A. Early ovarian ageing. Eur J Obstet Gynecol Reprod Biol 2004; 113: 126-133.
4. Burgering BM, Medema RH. Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J Leukoc Biol 2003; 73: 689-701.
5. Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 2003; 301: 215-218.
6. Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM. Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature 1996; 383: 531-535.
7. Yan C, Wang P, DeMayo J, DeMayo FJ, Elvin JA, Carino C et al. Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function. Mol Endocrinol 2001; 15: 854-866.
8. Perez GI, Robles R, Knudson CM, Flaws JA, Korsmeyer SJ, Tilly JL. Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency. Nat Genet 1999; 21: 200-203.
9. Davisson MT, Bechtel LJ, Akeson EC, Fortna A, Slavov D, Gardiner K. Evolutionary breakpoints on human chromosome 21. Genomics 2001; 78: 99-106.
10. Shibuya K, Nagamine K, Okui M, Ohsawa Y, Asakawa S, Minoshima S et al. Initial characterization of an uromodulin-like 1 gene on human chromosome 21q22.3. Biochem Biophys Res Commun 2004; 319: 1181-1189.
11. Nishizaki R, Ota M, Inoko H, Meguro A, Shiota T, Okada E et al. New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.3. Eye 2009; 23: 222-229.
12. Murphy C, Jinich S. Olfactory dysfunction in Down's Syndrome. Neurobiol Aging 1996; 17: 631-637.
13. Di Schiavi E, Riano E, Heye B, Bazzicalupo P, Rugarli EI. UMODL1/Olfactorin is an extracellular membrane-bound molecule with a restricted spatial expression in olfactory and vomeronasal neurons. Eur J Neurosci 2005; 21: 3291-3300.
14. Peters LM, Belyantseva IA, Lagziel A, Battey JF, Friedman TB, Morell RJ. Signatures from tissue-specific MPSS libraries identify transcripts preferentially expressed in the mouse inner ear. Genomics 2007; 89: 197-206.
15. Markopoulos F, Neubauer FB, Berger T, Scotti AL. Reassembling a system from the sensor to cerebral representation: the olfactory system in vitro. Neuroscience 2008; 156: 1048-1063.
16. Sammeta N, Hardin DL, McClintock TS. Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium. Mol Cell Neurosci 2010; 45: 398-407.
17. Wang W, Ni L, Yu Q, Xiong J, Liu HC, Rosenwaks Z. Expression of the Lycat gene in the mouse cardiovascular and female reproductive systems. Dev Dyn 2010; 239: 1827-1837.
18. Elvin JA, Yan C, Wang P, Nishimori K, Matzuk MM. Molecular characterization of the follicle defects in the growth differentiation factor 9-deficient ovary. Mol Endocrinol 1999; 13: 1018-1034.
19. Singtripop T, Mori T, Shiraishi K, Park MK, Kawashima S. Age-related changes in gonadotropin, prolactin and growth hormone levels with reference to the development of uterine adenomyosis in female SHN mice. In Vivo 1993; 7: 147-150.
20. Parkening TA, Collins TJ, Smith ER. Plasma and pituitary concentrations of luteinizing hormone, follicle-stimulating hormone and prolactin in aged, ovariectomized CD-1 and C57BL/6 mice. Exp Gerontol 1982; 17: 437-443.
21. van Zonneveld P, Scheffer GJ, Broekmans FJ, te Velde ER. Hormones and reproductive aging. Maturitas 2001; 38: 83-91; discussion 92-4.
22. Reynolds J, Keverne EB. The accessory olfactory system and its role in the pheromonally mediated suppression of oestrus in grouped mice. J Reprod Fertil 1979; 57: 31-35.
23. Smith TD, Siegel MI, Bhatnagar KP. Reappraisal of the vomeronasal system of catarrhine primates: ontogeny, morphology, functionality, and persisting questions. Anat Rec 2001; 265: 176-192.
24. Foltan R, Sedy J. Behavioral changes of patients after orthognathic surgery develop on the basis of the loss of vomeronasal organ: a hypothesis. Head Face Med 2009; 5: 5.
25. Kaneko N, Debski EA, Wilson MC, Whitten WK. Puberty acceleration in mice. II. Evidence that the vomeronasal organ isa receptor for the primer pheromone in male mouse urine. Biol Reprod 1980; 22: 873-878.
26. Bellringer JF, Pratt HP, Keverne EB. Involvement of the vomeronasal organ and prolactin in pheromonal induction of delayed implantation in mice. J Reprod Fertil 1980; 59: 223-228.
27. Nishizuka Y, Sakakura T. Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Science 1969; 166: 753-755.
28. Michael SD, Taguchi O, Nishizuka Y. Changes in hypophyseal hormones associated with accelerated aging and tumorigenesis of the ovaries in neonatally thymectomized mice. Endocrinology 1981; 108: 2375-2380.
29. Miller ME, Chatten J. Ovarian changes in ataxia telangiectasia. Acta Paediatr Scand 1967; 56: 559-561.
30. Perisic M, Arsenovic-Ranin N, Pilipovic I, Kosec D, Pesic V, Radojevic K et al. Role of ovarian hormones in age-associated thymic involution revisited. Immunobiology 2010; 215: 275-293.
31. Forsberg JG. Neonatal estrogen treatment and its consequences for thymus development, serum level of autoantibodies to cardiolipin, and the delayed-type hypersensitivity response. J Toxicol Environ Health A 2000; 60: 185-213.
32. McMahon HE, Hashimoto O, Mellon PL, Shimasaki S. Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology 2008; 149: 2807-2815.
33. Schomberg DW, Couse JF, Mukherjee A, Lubahn DB, Sar M, Mayo KE et al. Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult. Endocrinology 1999; 140: 2733-2744.
34. Schmidt D, Ovitt CE, Anlag K, Fehsenfeld S, Gredsted L, Treier AC et al. The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development 2004; 131: 933-942.
35. Wang W, Van De Water T, Lufkin T. Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development 1998; 125: 621-634.
36. Wang W, Chen X, Xu H, Lufkin T. Msx3: a novel murine homologue of the Drosophila msh homeobox gene restricted to the dorsal embryonic central nervous system. Mech Dev 1996; 58: 203-215.
37. Moore D, Chory J, Ribaudo RK. Isolation and purification of large DNA restriction fragments from agarose gels. Curr Protoc Immunol 2001, Chapter 10: Unit 10 5.
38. Nelson JF, Felicio LS, Randall PK, Sims C, Finch CE. A longitudinal study of estrous cyclicity in aging C57BL/6J mice: I. Cycle frequency, length and vaginal cytology. Biol Reprod 1982; 27: 327-339.
39. Salustri A, Ulisse S, Yanagishita M, Hascall VC. Hyaluronic acid synthesis by mural granulosa cells and cumulus cells in vitro is selectively stimulated by a factor produced by oocytes and by transforming growth factor-beta. J Biol Chem 1990; 265: 19517-19523.
40. Bookout AL, Mangelsdorf DJ. Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways. Nucl Recept Signal 2003; 1: e012.
41. Durlinger AL, Kramer P, Karels B, de Jong FH, Uilenbroek JT, Grootegoed JA et al. Control of primordial follicle recruitment by anti-Mullerian hormone in the mouse ovary. Endocrinology 1999; 140: 5789-5796.
42. Sheehan DCH, Barbara B. Theory and practice of Histotechnology. Battle Press, 1980.