Opposite Role of Kindlin-1 and Kindlin-2 in Lung Cancers

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Zhan, Jun ^a,b   Zhu, Xiang ^a,b   Guo, Yongqing ^c   Wang, Yunling ^a,b   Wang, Yuxiang ^a,b   Qiang, Guangliang ^c   Niu, Miaomiao ^a,b   Hu, Jinxia ^a,b   Du, Juan ^a,b   Li, Zhilun ^d   Cui, Jia ^a,b   Ma, Bo ^a,b   Fang, Weigang ^a,b   Zhang, Hongquan ^a,b  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c Sino Japan Friendship Hospital   (China)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

KINDLIN 1; KINDLIN 2; ONCOPROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER INVASION; CELL MIGRATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LARGE CELL CARCINOMA; LUNG CANCER; LUNG NON SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR DIFFERENTIATION;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CARRIER PROTEINS; CELL MOVEMENT; CYTOSKELETAL PROTEINS; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; HUMANS; LUNG NEOPLASMS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MIDDLE AGED; MUSCLE PROTEINS; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; TUMOR MARKERS, BIOLOGICAL;

EID: 84870492267     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050313     Document Type: Article

References (23)

1. Travis WD, Travis LB, Devesa SS, (1995) Lung cancer. Cancer 75: 191-202.
2. Travis WD, (2002) Pathology of lung cancer. Clin Chest Med 23: 65-81, viii.
3. Larjava H, Plow EF, Wu C, (2008) Kindlins: essential regulators of integrin signalling and cell-matrix adhesion. EMBO Rep 9: 1203-1208.
4. Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, et al. (2004) The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem 279: 6824-6833.
5. Montanez E, Ussar S, Schifferer M, Bosl M, Zent R, et al. (2008) Kindlin-2 controls bidirectional signaling of integrins. Genes Dev 22: 1325-1330.
6. Kindler T, (1954) Congenital poikiloderma with traumatic bulla formation and progressive cutaneous atrophy. Br J Dermatol 66: 104-111.
7. Jobard F, Bouadjar B, Caux F, Hadj-Rabia S, Has C, et al. (2003) Identification of mutations in a new gene encoding a FERM family protein with a pleckstrin homology domain in Kindler syndrome. Hum Mol Genet 12: 925-935.
8. Siegel DH, Ashton GH, Penagos HG, Lee JV, Feiler HS, et al. (2003) Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet 73: 174-187.
9. Weinstein EJ, Bourner M, Head R, Zakeri H, Bauer C, et al. (2003) URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. Biochim Biophys Acta 1637: 207-216.
10. An Z, Dobra K, Lock JG, Stromblad S, Hjerpe A, et al. (2010) Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration. Int J Cancer 127: 1999-2008.
11. Gong X, An Z, Wang Y, Guan L, Fang W, et al. (2010) Kindlin-2 controls sensitivity of prostate cancer cells to cisplatin-induced cell death. Cancer Lett 299: 54-62.
12. Shen Z, Ye Y, Dong L, Vainionpaa S, Mustonen H, et al. (2012) Kindlin-2: a novel adhesion protein related to tumor invasion, lymph node metastasis, and patient outcome in gastric cancer. Am J Surg 203: 222-229.
13. Sin S, Bonin F, Petit V, Meseure D, Lallemand F, et al. (2011) Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis. J Natl Cancer Inst 103: 1323-1337.
14. Talaat S, Somji S, Toni C, Garrett SH, Zhou XD, et al. (2011) Kindlin-2 expression in arsenite- and cadmium-transformed bladder cancer cell lines and in archival specimens of human bladder cancer. Urology 77: 1507 e1501-1507.
15. Kruger M, Moser M, Ussar S, Thievessen I, Luber CA, et al. (2008) SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell 134: 353-364.
16. Moser M, Nieswandt B, Ussar S, Pozgajova M, Fassler R, (2008) Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med 14: 325-330.
17. Wu WB, Zhang Q, Li Y, Shan SL, Li XY, et al. (2012) [Expression of kindlins and angiopoietins in acute myeloid leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 20: 7-11.
18. Harris ES, Smith TL, Springett GM, Weyrich AS, Zimmerman GA, (2012) Leukocyte adhesion deficiency-I variant syndrome (LAD-Iv, LAD-III): molecular characterization of the defect in an index family. Am J Hematol 87: 311-313.
19. van de Vijver E, Maddalena A, Sanal O, Holland SM, Uzel G, et al. (2012) Hematologically important mutations: leukocyte adhesion deficiency (first update). Blood Cells Mol Dis 48: 53-61.
20. Malinin NL, Plow EF, Byzova TV, (2010) Kindlins in FERM adhesion. Blood 115: 4011-4017.
21. Dowling JJ, Gibbs E, Russell M, Goldman D, Minarcik J, et al. (2008) Kindlin-2 is an essential component of intercalated discs and is required for vertebrate cardiac structure and function. Circ Res 102: 423-431.
22. Shin MS, Jackson LK, Shelton RW Jr, Greene RE, (1986) Giant cell carcinoma of the lung. Clinical and roentgenographic manifestations. Chest 89: 366-369.
23. Vaporciyan AA, Nesbitt JC, Lee JS, et al. (2000) Cancer Medicine. B C Decker pp. 1227-1292 ISBN 1-55009-113-1.