Causes of death of mutation carriers in Finnish Lynch syndrome families

Familial Cancer

Volumn 11, Issue 3, 2012, Pages 467-471

  Pylvänäinen, Kirsi ^a   Lehtinen, Tuula ^b   Kellokumpu, Ilmo ^a   Järvinen, Heikki ^b   Mecklin, Jukka Pekka ^a,c  

^a JYVÄSKYLÄ CENTRAL HOSPITAL   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Cancer family syndrome; Cause of death; Colorectal cancer; Hereditary non polyposis colorectal cancer; HNPCC; Lynch syndrome

Indexed keywords

ADULT; AGED; ARTICLE; CANCER MORTALITY; CANCER RISK; CAUSE OF DEATH; COLON CANCER; ENDOMETRIUM CANCER; FEMALE; FINLAND; GENE MUTATION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; PRIORITY JOURNAL;

ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; CAUSE OF DEATH; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; ENDOMETRIAL NEOPLASMS; FEMALE; FINLAND; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; MUTATION; NEOPLASMS; REGISTRIES;

EID: 84870469759     PISSN: 13899600     EISSN: 15737292     Source Type: Journal    
DOI: 10.1007/s10689-012-9537-3     Document Type: Article

References (16)

1. Aaltonen L, Johns L, Järvinen H et al (2007) Explaining the familial colorectal cancer risk associating with mismatch repair (MMR) deficient and MMR-stable tumors. Clin Cancer Res 13:356-361
2. Vasen HF, Watson P, Mecklin JP, Lynch HT (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the international group on HNPCC. Gastroenterology 116:1453-1456
3. Hampel H, Stephens JA, Pukkala E et al (2005) Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset. Gastroenterology 129:415-421
4. Mecklin J-P, Aarnio M, Läärä E et al (2007) Development of colorectal tumors in colonoscopic surveillance in Lynch Syndrome. Gastroenterology 133:1093-1098
5. Järvinen HJ, Mecklin JP, Sistonen P (1995) Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer. Gastroenterology 108:1405-1411
6. Vasen HFA, Abrdirahman M, Brohet R et al (2010) One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndrome. Gastroenterology 138:2300-2306
7. Watson P, Vasen HFH, Mecklin J-P et al (2008) The risk of extracolonic, extra-endometrial cancer in the Lynch syndrome. Int J Cancer 123:444-449
8. Vasen HF, Wignen JT, Menko FH et al (1996) Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. Gastroenterology 110:1020-1027
9. Järvinen HJ, Renkonen-Sinisalo L, Aktan-Collan K et al (2009) Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members. J Clin Oncol 27:4793-4797
10. Järvinen HJ et al (2000) Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer. Gastroenterology 118:829-834
11. Mecklin JP, Järvinen HJ, Peltokallio P (1986) Identification of cancer family syndrome. Gastroenterology 90:1099
12. Pylvänäinen K, Kairaluoma M, Mecklin J-P (2006) Compliance and satisfaction with long-term surveillance in Finnish HNPCC families. Fam Cancer 5:173-178
13. Parry S, Aung KW, Parry B et al (2011) Metachronous colorectal cancer risk for mismatch repair gene mutation carriers: the advantage of more extensive colon surgery. Gut 60:950-957
14. Nieminen T, Gylling A, Abdel-Rahman WM et al (2009) Molecular analysis of endometrial tumorigenesis: importance of complex hyperplasia regardless of atypia. Clin Cancer Res 15:5722-5783
15. Burn J, Gerdes A-M, Macrae F et al (2011) Long-term effect of aspiring on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet 378:2081-2087
16. Aktan-Collan K, Haukkala A, Mecklin JP, Uutela A, Kääriä inen H (2001) Psychological consequences of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC): a prospective follow-up study. Int J Cancer 93:608-611