ETV6 deletion is a common additional abnormality in patients with myelodysplastic syndromes or acute myeloid leukemia and monosomy 7

Haematologica

Volumn 97, Issue 12, 2012, Pages 1933-1936

  Wall, Meaghan ^a   Rayeroux, Kathleen C ^a   MacKinnon, Ruth N ^a   Zordan, Adrian ^a   Campbell, Lynda J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Acute myeloid leukemia; ETV6; Monosomy 7; Myelodysplastic syndromes

Indexed keywords

TRANSCRIPTION FACTOR ETV6;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION; CYTOGENETICS; ETV6 GENE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE DELETION; HUMAN; KARYOTYPE; MONOSOMY 7; MYELODYSPLASTIC SYNDROME; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 7; GENE DELETION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, ACUTE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-ETS; REPRESSOR PROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 84870465632     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2012.069716     Document Type: Article

References (12)

1. Haase D. Cytogenetic features in myelodysplastic syndromes. Ann Hematol. 2008;87(7):515-26.
2. Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, et al. Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood. 2010;116(3):354-65.
3. Schanz J, Tuchler H, Sole F, Mallo M, Luno E, Cervera J, et al. New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge. J Clin Oncol. 2012;30(8):820-9.
4. Sato Y, Suto Y, Pietenpol J, Golub TR, Gilliland DG, Davis EM, et al. TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies. Blood. 1995;86(4):1525-33.
5. Suela J, Alvarez S, Cifuentes F, Largo C, Ferreira BI, Blesa D, et al. DNA profiling analysis of 100 consecutive de novo acute myeloid leukemia cases reveals patterns of genomic instability that affect all cytogenetic risk groups. Leukemia. 2007;21(6):1224-31.
6. Tiu RV, Gondek LP, O'Keefe CL, Huh J, Sekeres MA, Elson P, et al. New lesions detected by single nucleotide polymorphism array based chromosomal analysis have important clinical impact in acute myeloid leukemia. J Clin Oncol. 2009;27(31):5219-26.
7. Walter MJ, Payton JE, Ries RE, Shannon WD, Deshmukh H, Zhao Y, et al. Acquired copy number alterations in adult acute myeloid leukemia genomes. Proc Natl Acad Sci USA. 2009;106(31):12950-5.
8. Bajaj R, Xu F, Xiang B, Wilcox K, Diadamo AJ, Kumar R, et al. Evidence-based genomic diagnosis characterized chromosomal and cryptic imbalances in 30 elderly patients with myelodysplastic syndrome and acute myeloid leukemia. Mol Cytogenet. 2011;4:3.
9. Streubel B, Sauerland C, Heil G, Freund M, Bartels H, Lengfelder E, et al. Correlation of cytogenetic, molecular cytogenetic, and clinical findings in 59 patients with ANLL or MDS and abnormalities of the short arm of chromosome 12. Br J Haematol. 1998;100(3):521-33.
10. Heinrichs S, Kulkarni RV, Bueso-Ramos CE, Levine RL, Loh ML, Li C, et al. Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics. Leukemia. 2009;23(9):1605-13.
11. Kolquist KA, Schultz RA, Furrow A, Brown TC, Han JY, Campbell LJ, et al. Microarray-based comparative genomic hybridization of cancer targets reveals novel, recurrent genetic aberrations in the myelodysplastic syndromes. Cancer Genet. 2011;204(11):603-28.
12. Rucker FG, Bullinger L, Schwaenen C, Lipka DB, Wessendorf S, Frohling S, et al. Disclosure of candidate genes in acute myeloid leukemia with complex karyotypes using microarray-based molecular characterization. J Clin Oncol. 2006;24(24):3887-94.