Serotonin dynamics and actions in the rat carotid body: Preliminary findings

Advances in Experimental Medicine and Biology

Volumn 758, Issue , 2012, Pages 255-263

  Ramirez, Maria ^a   Gallego Martin, Teresa ^a   Olea, Elena ^a   Rocher, Asuncion ^a   Obeso, Ana ^a   Gonzalez, Constancio ^a  

^a CSIC   (Spain)

Author keywords

5 HT; Carotid body; Catecholamine; HPLC.; Hypoxia; Ketanserin

Indexed keywords

CALCIUM ION; DOPAMINE; KETANSERIN; NORADRENALIN; POTASSIUM ION; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CAROTID BODY; CELL ACTIVATION; CHRONIC SUSTAINED HYPOXIA; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROCHEMICAL ANALYSIS; EXTRACELLULAR CALCIUM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; INTERMITTENT HYPOXIA; MALE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SEROTONIN RELEASE; TISSUE LEVEL;

EID: 84870458054     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-94-007-4584-1_35     Document Type: Conference Paper

References (27)

1. Chiocchio SR, Biscardi AM, Tramezzani JH (1967) 5-Hydroxytryptamine in the carotid body of the cat. Science 158(802):790-791
2. Chiocchio SR, King MP, Carballo L, Angelakos ET (1971) Monoamines in the carotid body cells of the cat. J Histochem Cytochem 19(10):621-626
3. Conde SV, Obeso A, Gonzalez C (2007) Low glucose effects on rat carotid body chemoreceptor cells secretory responses and action potential frequency in the carotid sinus nerve. J Physiol 585:721-730
4. Conde SV, Gonzalez C, Batuca JR, Monteiro EC, Obeso A (2008) An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells. J Neurochem 107(5):1369-1381
5. Dinger B, Gonzalez C, Yoshizaki K, Fidone S (1981) [3 H] spiroperidol binding in normal and denervated carotid bodies. Neurosci Lett 21(1):51-55
6. Fidone S, Gonzalez C, Yoshizaki K (1982) Effects of low oxygen on the release of dopamine from the rabbit carotid body in vitro. J Physiol 333:93-110
7. Ginzel KH, Kottegoda SR (1954) The action of 5-hydroxytryptamine and tryptamine on aortic and carotid sinus receptors in the cat. J Physiol 123(2):277-288
8. Gonzalez C, Almaraz L, Obeso A, Rigual R (1992) Oxygen and acid chemoreception in the carotid body chemoreceptors. Trends Neurosci 15(4):146-153
9. Gonzalez C, Almaraz L, Obeso A, Rigual R (1994) Carotid body chemoreceptors: From natural stimuli to sensory discharges. Physiol Rev 74(4):829-898
10. Gonzalez-Martín MC, Vega-Agapito V, Prieto-Lloret J, Agapito MT, Castañeda J, Gonzalez C (2009) Effects of intermittent hypoxia on blood gases plasma catecholamine and blood pressure. Adv Exp Med Biol 648:319-328
11. Gonzalez-Martín MC, Vega-Agapito MV, Conde SV, Castañeda J, Bustamante R, Olea E, Perez-Vizcaino F, Gonzalez C, Obeso A (2011) Carotid body function and ventilatory responses in intermittent hypoxia evidence for anomalous brainstem integration of arterial chemoreceptor input. J Cell Physiol 226(8):1961-1969
12. Hellström S, Koslow SH (1975) Biogenic amines in carotid body of adult and infant rats-a gas chromatographic-mass spectrometric assay. Acta Physiol Scand 93(4):540-547
13. Hui AS, Striet JB, Gudelsky G, Soukhova GK, Gozal E, Beitner-Johnson D, Guo SZ, Sachleben LR Jr, Haycock JW, Gozal D, Czyzyk-Krzeska MF (2003) Regulation of catecholamines by sustained and intermittent hypoxia in neuroendocrine cells and sympathetic neurons. Hypertension 42(6):1130-1136
14. Jacono FJ, Peng YJ, Kumar GK, Prabhakar NR (2005) Modulation of the hypoxic sensory response of the carotid body by 5-hydroxytryptamine: Role of the 5-HT2 receptor. Respir Physiol Neurobiol 145(2-3):135-142
15. Kirby GC, McQueen DS (1984) Effects of the antagonists MDL 72222 and ketanserin on responses of cat carotid body chemoreceptors to 5-hydroxytryptamine. Br J Pharmacol 83(1):259-269
16. Mccubbin JW, Green JH, Salmoiraghi GC, Page IH (1956) The chemoceptor stimulant action of serotonin in dogs. J Pharmacol Exp Ther 116(2):191-197
17. Peng YJ, Overholt JL, Kline D, Kumar GK, Prabhakar NR (2003) Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: Implications for recurrent apneas. Proc Natl Acad Sci U S A 100(17): 10073-10078
18. Peng YJ, Yuan G, Jacono FJ, Kumar GK, Prabhakar NR (2006) 5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase. J Physiol 576(Pt 1):289-295
19. Peng YJ, Nanduri J, Yuan G, Wang N, Deneris E, Pendyala S, Natarajan V, Kumar GK, Prabhakar NR (2009) NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J Neurosci (15):4903-4910
20. Reid G, Rand M (1951) Physiological actions of the partially puri fi ed serum vasoconstrictor (serotonin). Aust J Exp Biol Med Sci 29(6):401-415
21. Salmoiraghi GC, Page IH, McCubbin JW (1956) Cardiovascular and respiratory response to intravenous serotonin in rats. J Pharmacol Exp Ther 118(4):477-481
22. Sapru HN, Krieger AJ (1977) Effect of 5-hydroxytryptamine on the peripheral chemoreceptors in the rat. Res Commun Chem Pathol Pharmacol 16(2):245-250
23. Schneider JA, Yonkman FF (1954) Species differences in the respiratory and cardiovascular response to serotonin (5-hydroxytryptamine). J Pharmacol Exp Ther 111(1):84-98
24. Vicario I, Rigual R, Obeso A, Gonzalez C (2000) Characterization of the synthesis and release of catecholamine in the rat carotid body in vitro. Am J Physiol Cell Physiol 278(3):C490-C499
25. Yoshioka M (1989) Effect of a novel 5-hydroxytryptamine3-antagonist, GR38032F, on the 5-hydroxytryptamine-induced increase in carotid sinus nerve activity in rats. J Pharmacol Exp Ther 250(2):637-641
26. Zhang M, Nurse CA (2000) Does endogenous 5-HT mediate spontaneous rhythmic activity in chemoreceptor clusters of rat carotid body? Brain Res 872(1-2):199-203
27. Zhang M, Fearon IM, Zhong H, Nurse CA (2003) Presynaptic modulation of rat arterial chemoreceptor function by-HT: Role of K + channel inhibition via protein kinase C. J Physiol 551:825-842