Evaluation of immune responses and related patho-inflammatory reactions of a candidate inactivated EV71 vaccine in neonatal monkeys

National Medical Journal of China

Volumn 91, Issue 28, 2011, Pages 1977-1981

  Zhang, Xue Mei ^a   Zhao, Hong Ling ^a   Wang, Jing Jing ^a   Liao, Yun ^a   Na, Rui Xiong ^a   Wang, Li Chun ^a   Liu, Long Ding ^a   Gao, Jia Hong ^a   Tang, Dong Hong ^a   Wang, Cong Zhang ^a   Li, Qi Han ^a  

^a INSTITUTE OF MEDICAL BIOLOGY   (China)

Author keywords

Enterovirus infections; Immune response; Inflammatory reaction; Vaccine inactivated

Indexed keywords

ENTEROVIRUS 71 VACCINE; GAMMA INTERFERON; INACTIVATED VACCINE; INTERLEUKIN 6; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VIRUS VACCINE; VIRUS ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; BASOPHIL; CELL COUNT; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DRUG SAFETY; ENTEROVIRUS INFECTION; EVALUATION; EXPERIMENTAL MONKEY; IMMUNE RESPONSE; INFECTION PREVENTION; INFLAMMATION; NEWBORN; NONHUMAN; ANIMAL; BLOOD; CEREBROSPINAL FLUID; ENTEROVIRUS; IMMUNITY; IMMUNOLOGY; MACACA MULATTA; METABOLISM; VACCINATION;

ANIMALS; ANTIBODIES, VIRAL; ENTEROVIRUS A, HUMAN; ENTEROVIRUS INFECTIONS; IMMUNITY; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-6; MACACA MULATTA; VACCINATION; VACCINES, INACTIVATED; VIRAL VACCINES;

EID: 84870435461     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2011.28.011     Document Type: Article

References (16)

1. Yang F, Ren L, Xiong Z, et al. Enterovirus 71 outbreak in the People's Republic of China in 2008. J Clin Microbiol, 2009, 47: 2351-2352.
2. Fujimoto T, Chikahira M, Yoshida S, et al. Outbreak of central nervous system disease associated with hand, foot, and mouth disease in Japan during the summer of 2000: detection and molecular epidemiology of enterovirus 71. Microbiol Immunol, 2002, 46: 621-627.
3. Shimizu H, Utama A, Yoshii K, et al. Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997-1998. Jpn J Infect Dis, 1999, 52: 12-15.
4. 2008, 22: 475-477.
5. Shen WC, Chiu HH, Chow KC, et al. MR imaging findings of enteroviral encephaloymelitis: an outbreak in Taiwan. AJNR Am J Neuroradiol, 1999, 20: 1889-1895.
6. 2009, 38: 258-262.
7. Wong KT, Munisamy B, Ong KC, et al. The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways. J Neuropathol Exp Neurol, 2008, 67: 162-169.
8. Jia CS, Liu JN, Li WB, et al. The cross-reactivity of the enterovirus 71 to human brain tissue and identification of the cross-reactivity related fragments. Virol J, 2010, 7: 47.
9. Liu L, Zhao H, Zhang Y, et al. Neonatal rhesus monkey is a potential animal model for studying pathogenesis of EV71 infection. Virology, 2011, 412: 91-100.
10. Zhang Y, Cui W, Liu L, et al. Pathogenesis study of Enterovirus 71 Infection in Rhesus Monkeys [J/OL]. Lab Invest, 2011.[2010-10-09]. http://www.nature.com/labinvest/journal/vaop/ ncurrent/full/labinvest201182a html. [published online ahead of print May 9, 2011].
11. 2010, 15: 65-66.
12. 2006, 4: 195-196.
13. 2010, 25: 327-330.
14. 2008, 36: 55-56.
15. 2002, 20: 64-65.
16. 2010, 02: 119-122.